ANZCTR search results

This RCT aims to evaluate the feasibility and acceptability of daily consumption of a multi-ingredient high-protein beverage combined with a resistance exercise intervention in inactive older adults. Muscle function indicators, dietary intake and quality of life are also outcomes of interest. Research questions: (1) Is an intervention of 250mL high-protein beverage daily + resistance exercise twice weekly for 12 weeks feasible to older adults? (2) Is an intervention of 250mL high-protein beverage + resistance exercise twice weekly for 12 weeks acceptable to older adults? (3) Does an intervention of 250mL of low-protein beverage + resistance exercise twice weekly for 12 weeks improve muscle function parameters in healthy, physically inactive older adults? (4) Does an intervention of 250mL of high-protein beverage + resistance exercise twice weekly for 12 weeks result in a greater improvement in muscle function parameters in healthy, physically inactive older adults, compared to a low-protein beverage + resistance exercise intervention?

This study aims to assess whether postoperative anorectal pressures change over time and whether these changes differ according to the type of surgical procedure performed. Who is it for? You may be eligible for this study if you are a male or female aged 18 years or older who are undergoing colorectal surgery with formation of a primary colorectal anastomosis at Gold Coast University Hospital, including anterior resection or Hartmann’s reversal, and who are able to provide informed consent. Study details Those who are eligible will undergo anorectal pressure measurements using a small, single-use THD SensyProbe. Measurements will be taken once before surgery and then daily for up to five days after surgery, or until discharge from hospital if earlier. During each assessment, the probe will be gently inserted into the anal canal while the participant lies on their side, and resting anorectal pressure will be recorded. All participants will receive their planned surgery and standard postoperative care. There is no experimental treatment and no randomisation involved in this study. It is hoped that the findings will improve understanding of bowel function after colorectal surgery and help inform future strategies to reduce complications such as anastomotic leak.

Shoulder arthroscopy is commonly performed and postoperative pain can be substantial. The superior trunk block provides effective pain relief but may still impair diaphragm function in some patients. Although this is often well tolerated in healthy individuals, it may be clinically important in older or frail patients and those with pre-existing respiratory disease. Selective shoulder nerve blocks have been developed to target the nerves supplying the shoulder while potentially preserving diaphragm function, but clinical evidence supporting this approach remains limited. This randomised feasibility trial will compare the SAXIPec technique with the superior trunk block in adults undergoing elective shoulder arthroscopy. The primary aim is to determine whether a larger randomised controlled trial can be successfully conducted by assessing recruitment, successful delivery of the allocated intervention and completeness of follow-up. The study will also collect preliminary information on pain, quality of recovery, opioid consumption and diaphragm function to inform the design of a future definitive trial.

Parkinson’s disease is the fastest-growing brain disorder in the world. It can greatly affect people’s quality of life and put strain on carers. We still don’t know if a team-based rehabilitation approach works better than standard medical care. This small study (from May 2022 to November 2024) compared two approaches: the best medical treatment plus a team-based rehabilitation program, and the best medical treatment on its own.

Vial Australia Pty Ltd is conducting a first-in-human study of VIAL-IL13xTSLP, an experimental bispecific antibody that targets two inflammatory proteins (IL-13 and TSLP) involved in asthma. The study will evaluate the safety, tolerability, and biological effects of the drug in healthy volunteers.

Recent advancements in generative AI technology provide an opportunity to improve the quality and consistency of discharge summaries. This study aims to evaluate the use of generative AI in producing discharge summaries that conform to the National Guidelines for On-Screen Presentation of Discharge Summaries in Australia. This study will provide evidence on the potential benefits and risks of using generative AI to enhance the quality and efficiency of discharge summaries in Australian public hospitals, supporting the development of safer and more effective clinical documentation practices, in the event that AI products may contribute positively to the quality and timeliness of discharge summaries.

This study compares how the body absorbs leucine, a protein building block important for maintaining muscle health, after eating four protein-rich whole foods: boiled soybeans, natto, tempeh, and lean beef. The study is conducted in healthy older adults, a population particularly susceptible to age-related muscle loss. We aim to investigate (i) whether boiled soybeans lead to less leucine absorption in the body than lean beef, and (ii) whether fermenting soy, as in natto and tempeh, improves leucine absorption compared to non-fermented soybeans. We will also record how palatable each meal is and monitor participants' gastrointestinal comfort after eating. Findings will help determine whether fermented soy foods could serve as a practical plant-based alternative to beef for supporting muscle health in older adults.

This study evaluates the IIUIH System of Care version 2 (ISoC2), an Indigenous designed client-centred model of primary health care implemented by an Aboriginal and Torres Strait Islander community-controlled health service in Southeast Queensland. The model focuses on relational care, strengthening relationships between clients and care teams and supports strengths-based approaches to care. The study examines whether ISoC2 is associated with improvements in access to care, quality of care, and health and wellbeing outcomes for clients, including chronic disease management. It also evaluates how the model works in practice, including barriers and enablers to implementation, and whether it is cost-effective. This is an evaluation of a reformed system of care led by an Aboriginal and Torres Strait Islander community-controlled health service, aimed at ensuring services continue to deliver culturally grounded, relational, and strengths-based care while improving outcomes over time. Data are collected using routinely collected health records, client surveys, and yarning with clients and staff. The recruitment start date (01/01/2016) reflects commencement of routine clinical data capture within the MMEx electronic medical record by IUIH clinicians, rather than the later study implementation date. All participant data were collected during routine care and accessed for research following ethics approval. A waiver of consent was granted under the Public Health Act (PHA), with data custodian approvals (including IUIH and Queensland Health Statistical Services Branch) to enable data extraction and linkage to hospital admissions and emergency department datasets.

This study is testing whether a new prehabilitation program is acceptable and useful for people having a major surgery (i.e., free flap reconstruction) for head and neck cancer. Who is it for? You may be eligible for this study if you are an adult undergoing head and neck free-flap reconstructive surgery (any flap type) either for malignant or benign tumours or other benign conditions at Chris O'Brien Lifehouse. Study details All participants will be supported before surgery with information, a screening checklist, and daily activities focused on nutrition, exercise, oral health, and wellbeing. This will be provided through a one-off contact at the pre-admission appointment. Participants will be asked to complete questionnaires and interviews evaluating their experience. It is hoped that findings from this study will help develop a prehabilitation program which is feasible, acceptable and effective in supporting head and neck cancer patients undergoing major reconstructive surgery.

This study will evaluate whether a brief online psychosocial screening questionnaire can help identify these concerns earlier and connect young people to appropriate support. Young people aged 13–25 years with a chronic illness receiving care through participating hospital services will be invited to take part. Participants will complete online questionnaires about their health, wellbeing, and experiences of care. Those allocated to the screening group will also complete a brief psychosocial screening questionnaire, with any identified concerns reviewed by the clinical team according to usual care pathways with support, referral and ongoing care as appropriate. The study aims to determine whether routine psychosocial screening and targeted follow-up improves wellbeing, quality of life, and access to support services for young people with chronic illness.