ANZCTR search results

This is a cluster randomised trial of a novel skin preparation, OPAL X Wound Healing Cream, It is based in multiple aged care facilities within a statewide, church-based Aged Care provider. The comparator will be the standard moisturising cream currently in use at each facility. Randomisation will be by facility to minimise disruption to the routines of each facility by the research process. This is a pilot trial prior to a full trial. The hypotheses of the full trial will be: That OPAL X cream used as the moisturiser in best practice wound management regimes, vs standard moisturising creams will: 1. have reduced time to full healing.for acute wounds (like skin tears); 2 have reduced time to full healing.for chronic wounds (like skin ulcers); 3. Reduce the incidence rate of new skin tears on the affected limb 3. Generate improved quality of the undamaged skin of the affected limb. All people will be approached to participate, but only people with existing chronic wounds at enrolment, or who develop an acute skin injury in the first 2 months or until the target number of wounds is reached.

This study aims to determine whether using clinical and genetic calorie-to-satiation scores can help select the most effective weight loss medication for people with obesity. Participants will undergo detailed assessments and be randomly assigned to receive either phentermine–topiramate or a GLP-1–based medication (semaglutide or tirzepatide). The study will compare how much weight participants lose after reaching a stable treatment dose. We hypothesise that individuals with different calorie-to-satiation scores will respond better to specific medications, allowing more personalised treatment. The findings may help improve weight loss outcomes and reduce trial-and-error prescribing in obesity care.

This study aimed to explore any correlation between salivary and serum ferritin in 150 women undergoing elective surgery, to evaluate the feasibility of using salivary ferritin as a non-invasive biomarker for iron deficiency. Participants provided a fasted morning saliva sample and blood sample prior to their surgery. It was hypothesised that ferritin levels in saliva would accurately reflect serum ferritin levels.

This study is evaluating a new GP-integrated model of care for children with developmental and behavioural concerns in rural Western Australia. In this model, specially trained rural general practitioners work collaboratively with paediatricians to provide earlier developmental assessment and management for children while they are awaiting specialist review. The study will assess whether this model improves access to care, reduces wait times, and is acceptable to children, families and healthcare providers. The study hypothesis is that a GP-integrated developmental clinic model will improve timely access to paediatric developmental assessment and provide an acceptable and feasible model of care for rural communities.

Postnatal depression affects around one in ten mothers and can negatively impact the mother–infant relationship, which is critical for healthy child development and mental health. Treatment for maternal depression does not always lead to improvements in this relationship, indicating a need for targeted interventions. eHUGS is an online program adapted from an evidence-based face-to-face intervention, designed to strengthen the mother–infant relationship and support infant mental health. This trial will randomise 126 mothers with infants under 12 months to either the eHUGS program or waitlist control who receive links via SMS to publicly available online parenting resources. Outcomes will be assessed at baseline, post-intervention, and 3-month follow-up. The study will evaluate effects on infant social-emotional development (primary outcome), and secondary outcomes include the mother–infant relationship, perceptions of child temperament and behaviour, parenting self-efficacy, maternal mental health and program satisfaction and usage. It is expected that infants of mothers allocated to eHUGS will show significantly greater improvements in infant social-emotional development at 3 months post-intervention than controls.

The primary aim of this trial is to determine whether the nervous systems ability to control pain will predict clinical response to a rehabilitation exercise program in individuals with patellar tendinopathy. We hypothesis that individuals with a nervous system that up-regulates pain will have a poorer response to rehabilitation.

Understanding the effect of intoxication on witnesses is important to the legal system, but key gaps remain. While research on alcohol and memory is advancing (e.g., Jores et al., 2019), little is known about other substances in an eyewitness context. There is minimal research on amphetamines and event memory, and no known research on amphetamines and face recognition in a line-up context. Further gaps remain around dosage, timing, and expectancy effects. Many crimes are distressing, yet minimal research has explored intoxication and memory in the context of a distressing event. The role of stress warrants particular attention given that stress hormones are released during amphetamine use, and it remains unclear whether alcohol attenuates the stress response, whether stress alters alcohol metabolism, and how either may interact with memory. Critically, no known research has examined the combined effects of alcohol and amphetamine intoxication on eyewitness memory, despite the relevance of polydrug use to real-world forensic contexts. Study hypotheses: alcohol is anticipated to impair memory completeness but not accuracy, while dexamfetamine may enhance memory relative to placebo. The polysubstance condition (dexamfetamine + alcohol) is expected to produce differential effects on memory relative to either substance alone. An exploratory aim is to investigate whether acute stress moderates drug response and subsequently impacts memory.

Dry eye affects 20% adults and imparts substantial economic burden, however there is a limited understanding of the complex mechanisms underlying dry eye disease, particularly immune-mediated processes, and how inflammation might be optimally modulated to achieve therapeutic control of the condition. ‘Light therapy’ has recently emerged as a potential non-invasive treatment for dry eye. In particular, low-level light therapy, using light emitting diodes (LEDs), has been developed with the rationale of modifying relevant biological processes, such as increasing cellular metabolism with production of heat within the eyelids. This is proposed to improve the flow of oil (known as meibum) into the tears, from specialised oil (meibomian) glands in the eyelids. These glands are often dysfunctional in dry eye disease, an associated condition known as meibomian gland dysfunction (MGD). While these treatments are being rapidly adopted in practice, there remains a lack of evidence on the impact of ‘light therapy’ on ocular inflammation and/or the immune cell populations at the ocular surface. The primary purpose of this study is to characterise the in vivo features of human corneal immune cells when exposed to different coloured light stimuli (red vs blue) used in low-level light therapy in the treatment of dry eye associated with MGD.

This research project is testing a new treatment. The new treatment is a vaginal ring pessary that delivers estriol to treat both pelvic organ prolapse (POP) and genitourinary syndrome of menopause (GSM) at the same time. We hypothesise that, compared to the existing vaginal pessary and estrogen therapy in the market, the estriol integrated vaginal pessary is an effective treatment for symptomatic pelvic organ prolapse and genitourinary syndrome of menopause (GSM) without additional treatment side effects.

The aim of this study is to assess the safety and tolerability of ARG-397, an experimental new medicine being developed to help reduce the formation of blood clots. Blood clots can block blood vessels and may lead to serious medical conditions. This study will involve healthy volunteers who will receive a single dose of ARG-397. Researchers will monitor participants for any side effects, measure how long ARG-397 stays in the bloodstream, and assess whether it affects the blood’s ability to clot.