ANZCTR search results

Brief description of the study purpose This study is testing whether a newer biopsy technique, called cryobiopsy, can be used on its own to accurately diagnose lung nodules. It will also look at whether the order in which different biopsy methods are performed affects the accuracy of the diagnosis. Who is it for? You will be eligible if you are an adult who are scheduled to have a bronchoscopy with radial endobronchial ultrasound (R-EBUS) at Westmead Hospital or Westmead Private Hospital may be able to take part. Study details All participants who are eligible will undergo a bronchoscopy procedure using R-EBUS as part of their routine care. During this procedure, several different biopsy techniques will be performed: up to 6 forceps biopsies, 3 fine needle aspirations, 1 brushing, and up to 5 cryobiopsies. The order of sampling will be randomised. The tissue samples will be examined by pathologists to see which technique provides the most accurate diagnosis. It is hoped this research will show whether cryobiopsy can replace other methods, improving the accuracy and efficiency of diagnosing lung nodules and helping patients receive the right treatment sooner.

A large proportion of INOCA (ischaemia with non-obstructive coronary arteries) patients continue to have symptoms despite being on multiple medications. Sildenafil was studied in a small international study in 2011 which showed some early promising results. However, to the best of our knowledge, there have been no subsequent studies using Sildenafil to treat INOCA. The purpose of this study is to see if Sildenafil improves INOCA symptoms.

PRISM is a prospective registry and biorepository, established to facilitate the collection of clinical data and biospecimens with the aim of improving infection prevention, infection surveillance and infection management in patients receiving disease modifying therapies for autoimmune conditions. Research questions which may be address relate to the real-world epidemiology of infections in patients receiving disease modifying therapies, impact of disease modifying therapies on vaccine response, and the effect of sequential immunological therapies on the immune system.

This is a prospective observational exploratory study investigating the immunological effects of RSV vaccination in pregnant women. All pregnant women will receive a single dose of the Abrysvo RSV vaccine. Detailed exploratory systems biology assays (transcriptomics, epigenetics, lipidomics, metabolomics) and flow cytometry will be performed to investigate the broad immunomodulatory effects of RSV vaccination.

This study aims to find out whether adding an opioid painkiller (tapentadol) to standard pain relief (paracetamol and ibuprofen) provides better pain control than using standard pain relief alone after surgery for broken bones. Adults who have had surgery for a fracture will be randomly assigned to receive either tapentadol or a placebo for breakthrough pain during the first week after leaving hospital. The study will measure pain levels, recovery, and any side effects to help determine the safest and most effective way to manage pain after surgery following hospital discharge.

This study is testing a new support program called Transition Compass to help young people with long-term health conditions transition smoothly from children’s to adult healthcare services. Who is it for? You may be eligible for this study if you are aged 16 to 21 and have a long-term health condition diagnosed in childhood, such as cancer, diabetes, asthma, or epilepsy. You should have been receiving specialist paediatric care for at least two years and be approaching discharge to adult healthcare services. You should also be expected to continue receiving regular specialist care for at least two more years. Study details Participants in this study will be allocated to one of two groups by chance: 1. Current usual care as provided by their treating paediatric and adult health services. This may include standard discharge planning, referrals, and follow-up arrangements. 2. A mobile-based support program, called "Transition Compass" to support the transition from children’s to adult healthcare. The program includes supportive messages, access to a transition coach, and monthly educational videos to guide participants through topics such as managing their health, navigating adult services, and staying well during the transition. Participants will be followed for two years. Information will be collected on ongoing engagement with healthcare services, including attendance at regular appointments with adult specialists, any hospitalisations or emergency visits, and participants’ experience of the transition process, including satisfaction with care. It is hoped that this research will help determine if Transition Compass improves outcomes for young Australians with chronic illness, improves patient experience and helps guide future healthcare policy.

This randomised controlled study will use an assessor-blinded, two-way crossover design to assess the effects of a combination of Tion with 60% CPP-ACP/SnF2 applied under a retainer, and a placebo (no gel) treatment to remineralise/conceal white spots on enamel surfaces using an intra-oral remineralisation model. The Tion gel contains hydrogen peroxide, and the 60% CPP-ACP gel will contain 60% (w/w) CPP-ACP with 1100 ppm fluoride as SnF2. Participants will be randomly allocated to one of the two treatments for each 10 consecutive-day treatment period, during which participants will wear a palatal appliance for 24 hours a day. The participants will rest from the study for one week between each treatment period (washout period). Lay Hypothesis: A combination of a whitening gel TiON and a 60% CPP-ACP/SnF2 gel under a custom retainer can help repair and reduce the appearance of white spots on teeth better than using no treatment (saliva only) control.

This longitudinal study will evaluate surgical and patient outcomes following a Hybrid Transforaminal Lumbar Interbody Fusion (TLIF) performed by A/Prof Paul Licina at Brisbane Private Hospital. The Hybrid TLIF integrates the benefits of both open and minimally invasive techniques to enhance surgical precision and recovery. Using advanced technologies — including the CIRQ robotic alignment module, EOS imaging, and the SpineHUB digital education app — the study will capture comprehensive surgical, functional, and patient-reported outcomes. By combining robotic guidance, 3D imaging, and digital engagement, this research aims to provide new insights into optimising spinal fusion surgery and improving patient experience. Findings will help inform best practice and future innovation in spine care.

This study is workflow assessment and usability study of the EMVision First Responder Brain Scanner in aeromedical workflows. This study collects EMVision brain scans including workflow metrics generated from scan procedures timestamps. This study hypothesises that the proposed EMVision First Responder Brain Scanner aeromedical workflow is suitable for use in an emergency aeromedical stroke response.

This trial is the first stage of a staged workflow assessment and data collection study of the EMVision First Responder Brain Scanner for patients suspected of suffering from an acute stroke. This stage of the study is a usability and workflow assessment used qualify the impact of the EMVision First Responder Brain Scanner procedures on the MSU workflow. This study collects EMVision brain scans including workflow metrics generated from scan procedures timestamps. This study hypothesises that the impact of the EMVision First Responder Brain Scanner procedure does not impact the emergency stroke MSU workflow.