ANZCTR search results

60 participants will be recruited to complete 12 weeks of either single-leg high intensity interval cycling or double-leg high intensity interval cycling. This study aims to determine the functional, psychosocial and physiological effects of cycle exercise training using either one or two legs. This will be a parallel randomised group design recruiting individuals 18-80 years of age with established coronary artery disease.

The primary purpose of this study is to determine the efficacy and safety of carfilzomib-thalidomide-dexamethasone (CarTD) therapy for newly diagnosed transplant-eligible multiple myeloma (NDMM) patients who did not respond adequately to initial bortezomib-based therapy. Who is it for? You may be eligible to join this study if you are aged over 18 years, have been diagnosed with symptomatic NDMM as per International Myeloma Working Group (IMWG) criteria, are eligible for high-dose melphalan conditioned autologous stem cell transplant (ASCT) and failed to achieve a minimum response or partial response on 2 or 4 cycles of prior bortezomib-based induction therapy respectively. Study details Enrolled participants will first undergo 4 x 4-week cycles of salvage CarTD therapy, followed by an additional 2 cycles if they do not achieve a stringent complete response. Participants will then receive melphalan-conditioned ASCT, followed by 2 cycles of consolidation CarTD therapy. Patients will be monitored for myeloma response and safety and tolerability of CarTD therapy using blood samples, and the assessment of toxicities (adverse event review) as well as for disease progression and survival information for up to 3 years following the completion of treatment. It is hoped that the findings of this trial will provide an evaluation of the efficacy and safety of CarTD salvage and consolidation therapy in multiple myeloma patients who do not respond to the standard care bortezomib-based therapy.

Stroke continues to be the leading cause of adult disability in Australia. Research reveals half of all stroke survivors present with sensory deficits, resulting in difficulty feeling everyday objects through touch and knowing where one’s limbs are in space. Rehabilitation of sensory deficits has historically been neglected, with an evidence-practice gap existing between research knowledge and clinical practice. The primary aim of this implementation study is to improve the health outcomes and reduce the burden of sensory loss in stroke survivors. Implementation will be achieved through the use of evidence-based research-transfer methods and outcomes will include functional outcomes for stroke survivors and effective transfer of knowledge to occupational therapists and physiotherapists.

The primary purpose of this study is to evaluate whether proactive telephone or online support for lung cancer patients can improve patient wellbeing. Who is it for? You may be eligible to join this study if you are aged 18 years or over, have been diagnosed with any form of lung cancer in the past 4 months and have internet access on any device. Study details Lung cancer patients often experience poorer prognosis, more severe physical effects and more pronounced psychosocial distress than patients with other major cancers. A highly accessible and sustainable source of personalised support for cancer patients is the Cancer Council Helpline in each state. Participants in this study will be randomly allocated (by chance) to receive either telephone support including at least 1 telephone call from the Helpline, Online support by email or live web chat including at least 1 email from the Helpline, or to receive a booklet 'Understanding lung cancer' in the mail. Helpline support provided to the telephone and email support groups includes information, linking callers with services in their local area, and providing emotional support. When patient distress is high or medical advice is required, referral to relevant services within or outside the Cancer Council will be offered. All participants will be asked to fill out a mailed questionnaire at 3 and 6 months after their enrolment in the study. It is hoped that this study will provide evidence of whether a proactive approach can recruit a high proportion of lung cancer patients to Helpline, whether the Helpline model of information and support is effective in improving wellbeing, and whether an electronic approach can provide equivalent outcomes to a telephone-based approach. These results will have national and international relevance for decisions about community-based information and support.

This project will test the hypothesis that functioning and mental wellbeing will be improved in people with type 2 diabetes and comorbid depression following the use of a fully-automated mobile phone and web-based mental health intervention (‘myCompass’) for 12 weeks, compared with those who receive a placebo intervention.

Cognition and aggression were assessed during four phases of the menstrual cycle across one baseline cycle with no treatment, followed by two cycles with either 200 mg isoflavones daily or placebo. A comparison group of long term oral contraceptive users were also included and received only placebo during the treatment cycles. Brain activity was measured using electroencephalography (EEG) during the baseline and second treatment cycles.

The main aims of the current study are to: (a) investigate the efficacy of intensive individual cognitive behavioural therapy (CBT) for social anxiety disorder (SAD) and (b) examine the capacity of the stress hormone cortisol to predict treatment response to intensive CBT in individuals with SAD. This project will test these aims in a preliminary, single group open trial design. Treatment will consist of three 60-minute sessions of CBT each week over four weeks, (12 hours in total). Saliva samples will be collected at 3 of these 12 sessions in order to measure cortisol levels in response to exposure therapy.

The study is a single blind randomised controlled trial to determine whether a nurse-led clinic which uses a mobile enable web app (a computer program that also works on a smartphone or tablet) to guide discussion between the nurse and patient, can improve lifestyle risk factors and health related quality of life (HR-QoL) in participants with AF. The study aims to provide evidence of feasibility with the intention to seek funding for a larger study.

This project aims to compare the efficacy, acceptability and feasibility of three internet-delivered programs for adults with depression and/or anxiety symptoms: an internet-delivered cognitive behavioural therapy program versus an internet-delivered mindfulness-enhanced cognitive behavioural therapy program versus mindfulness skills training program, compared to usual care. Up to 200 people with elevated symptoms of depression and/or anxiety will be randomly assigned to one of the three treatment groups or the treatment as usual control group (TAU). All groups will commence their intervention immediately, except for the TAU group who will receive the mindfulness-enhanced iCBT program after the 14 week waiting period. The efficacy of the three programs will be compared at post-treatment (immediately after the treatment period finishes) and 3-month follow-up by comparing their symptoms of depression, anxiety and distress.

Falls have also been identified as a serious health issue which can cause serious physical injuries and fear of falling. People living with intellectual disability (ID) in residential settings have been reported to have a higher incidence of falls and experience falls at a younger age than the general older population. There are existing comprehensive multi-targeted interventions and services for the older mainstream populations, however, its been reported that there are no suitable falls prevention guidelines or specific services targeting people with ID and their care providers. The purpose of this study is to gain an understanding of the nature of falls in people with ID and to identify gaps in recommended falls prevention service pathways that people with ID may face. The study will also investigate the barriers that people with intellectual disability may face in engaging in evidence based falls prevention guidelines. This will allow the development of preliminary recommendations for falls prevention that are specifically targeted for people with ID.