ANZCTR search results

This study will examine the efficacy of collaborative case conceptualization (CCC), a novel assessment approach (based on the Maudsley Model of Treatment for Adults with Anorexia Nervosa), compared to standard assessment as usual (AAU) for adults with Anorexia Nervosa. It is hypothesized that, relative to usual care, CCC will result in improvements in general psychopathology and quality of life 12-month follow-up. This study will also examine post-assessment outcomes and potential mediators of the effect of CCC (i.e., obsessive-compulsive and perfectionistic behaviours and cognitions, avoidant behaviours and cognitions, pro-anoretic beliefs and responses of close others).

This is a pilot evaluation of the ability of a web and text-book based training program to train medical scribe students to be ready to commence work as a trainee medical scribe in an Emergency Department

Sacral Neuromodulation or SNM is a well-established treatment for bowel leakage, also known as faecal incontinence. It uses a small device (a stimulator) that is implanted under the skin in the upper buttock area. It then transmits electrical pulses through a small wire that is positioned close to the sacral nerve to improve bowel control and function. Despite being very successful for the treatment of faecal incontinence, the exact mechanism by which it works remains unknown. It is possible that SNM influences the way that the brain and gut interact by ‘resetting’ its function back to normal, a bit like restarting a computer after it ‘crashes’. If this is true, long-term SNM may not be necessary to control symptoms. The aim of this study is to assess the impact of SNM on bowel symptoms and bowel control, particularly when SNM is switched off. The group studied will include patients with faecal incontinence who have successfully been stimulated for at least 6 months. A total of 20 patients will be recruited and randomised into two groups; each group will have two cycles of different exposure. Each cycle will last for 6 weeks and will involve either turning the stimulator Off or On. Patients and assessors will be unaware whether the stimulator is On or Off, so as to reduce the effect of bias. At each 6-week cycle, all patients recruited will attend the hospital to adjust their stimulator and to complete a questionnaire and undergo physiology tests to measure bowel control and function. At the end of the study the SNM will be switched back to the original setting. Study outcomes will involve assessment of bowel symptoms, severity of faecal incontinence, quality of life scores and anorectal physiological function. This study will provide important information in understanding and treating disorders of bowel function and bowel leakage.

Finger-prick capillary glucose levels typically inform insulin administration in T1D. RT-CGM involves using a subcutaneous sensor to measure interstitial fluid glucose levels continuously and provides the person with the glucose level in real-time, as well as the rate and direction of change in the glucose. There is an increasing body of evidence indicating that RT-CGM in combination with an insulin pump results in an improvement in glycaemia and reduces hypoglycaemia, compared with finger-prick glucose measurement and multiple daily injections with insulin in people with T1DM. However, data is limited regarding the use of RT-CGM in conjunction with multiple daily insulin injections. The study aims to evaluate the user acceptance of the RT-CGM device in patients with T1D, as well as to evaluate its' impact on glycaemic control.

Falls are the leading cause of injury-related hospitalisation in older people in Australia. Older people are at increased risk of falls after hospital discharge and these falls can lead to injury and loss of independence and quality of life. However older people have been found to have low levels of knowledge about falls and may be reluctant to engage in falls prevention activities, such as exercise. The primary aim of this trial is to determine if providing tailored falls prevention education that includes the provision of multimedia materials as well as individual health professional consultations and reinforcement in hospital and after discharge reduces falls rates in older people after discharge from hospital. A randomised trial will compare outcomes between a group that receive the education in addition to usual care and a group that receive social visits in addition to usual care.

In this study we are comparing two laryngeal mask airways (LMAs), a current model which is commonly used with the latest model of the device for flexibility, traumatic effect and ease of optimal positioning. We are performing a randomised controlled study to find out which device performs better in clinical practice. We are randomly selecting people to the groups and giving each a different device. The results will be compared to see if one is better. There is a 50:50 chance of being in one group or the other.

The purpose of this study is to determine if two cosmetic products, a cleanser and a moisturiser, containing ceramides can be of benefit for those with moderate eczema. It is hypothesised that daily use of such products will be of benefit as part of the maintenance regimen for those with moderate eczema.

The hypothesis of this study is that transmitted acoustic energy delivered via the collar bones to the pressure receptors in the neck will modulate the nervous system to reduce blood pressure and heart rate in normal individuals. The main aim is to investigate the effect of mechanical vibration delivered non-invasively via the collar bones to affect the heart rate and blood pressure. Primary Objective: To determine if acute use of the Sympara Therapeutic System (STS) device reduces sympathetic activity in three distinct subject populations. A. Healthy controls B. Healthy individuals with elevated sympathetic activity (e.g. anxiety) C. Individuals with early to mild hypertension Study Design: Acute, prospective, study to evaluate the potential mechanism of action for the STS.Participants will be randomized in a 1:4 ratio to either a sham or active STS device.

Only a few patients (less than 10%) survive cardiac arrest that lasts for more than 30 minutes, even if the cause is potentially reversible. ECMO is a blood pump that can be placed in large blood vessels in the groin and takes over the functions of the heart and lungs. This study will look at how many people survive persisting cardiac arrest when ECMO is used to support the heart until the cause of the cardiac arrest has been treated and the heart has had time to recover.

The primary purpose of this study is to determine the effect of metformin on certain growth factors that drive progression of prostate cancer. Who is it for? You may be eligible to join this study if you are aged 50 to 80 years, with histologically confirmed prostate cancer of early or locally advanced stage, or metastatic prostate cancer with bone involvement only and have been on stable treatment with androgen deprivation therapy (ADT) in the form of a GnRH agonist for more than 6 months. Study details: Metformin is a commonly used medication for the treatment of type 2 diabetes. We have early evidence that the use of metformin may slow down the growth of prostate cancer cells. However, the exact mechanism remains unknown. In this study participants will be randomly allocated (by chance) to start with either metformin or placebo treatment. Metformin or placebo tablets will be given twice daily over 6 weeks each. You will not know which tablet you are taking until after the trial. Blood samples will be taken at baseline and 6 and 12 weeks in order to assess how metfromin affects levels and activity of growth factors involved in prostate cancer progression.