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Adequate delivery of oxygen to the organs is essential for human life and all organs of the body require oxygen to function normally. Normally, oxygen makes up just under a quarter of the gas in the air we breathe. In patients who require life support, much higher amounts of oxygen (up to 100% oxygen) can be used. Sometimes it is necessary to provide higher than normal amounts of oxygen to patients on life support in order to achieve normal levels of oxygen in the blood. However, patients who require life support often receive more oxygen than is absolutely necessary to achieve normal oxygen levels in the blood. This commonly causes abnormally high levels of oxygen in the blood. The purpose of this study is to find out whether a conservative oxygen strategy, which avoids giving more oxygen than is necessary to maintain normal levels of oxygen in the blood, improves ventilator-free days (the number of days free from life support) compared to standard care.

Cardiovascular disease (CVD) is the leading cause of death worldwide.Two major risk factors for CVD are high levels of blood cholesterol and inflammation. It is well known that dietary supplementation with foods enriched with plant sterols lower cholesterol levels by 10% in 3 weeks. It is also known that curcumin (found in tumeric) has anti-inflammatory properties. This project aims to investigate if combined dietary supplementation with plant sterols and curcumin reduces blood cholesterol and inflammation to a larger extent than either of the treatments alone.It is expected that participants will have improved levels of blood cholesterol, fatty acids and markers of inflammation as well as an overall reduced 10-year risk of developing CVD. The findings of this research could translate to wider public health benefits through the development of a single functional food that combines both phytosterols and curcumin (e.g. margarine spread or reduced-fat milk). This could be easily incorporated into the regular diet of the general Australian adult population in order to minimise the risk of developing cardiovascular disease.

The purpose of our current study is to characterize the immediate short term impact of iron repletion on heart failure patients’ quality of life, exercise tolerance, hemodynamic indices, and serum BNP and ST2 levels; this will in turn add to the growing body of evidence supporting the investigation and treatment of iron deficiency in patients with congestive cardiac failure. Our hypothesis is that intravenous ferric carboxymaltose in congestive cardiac failure patients with concomitant iron deficiency will improve quality of life (as measured by the Kansas City Cardiomyopathy Questionnaire Score), short term exercise capacity (as measured on the six minute walk test), hemodynamic indices (as measured via impedance cardiography), and blood profile (BNP and ST2 levels )when compared with a placebo infusion of 0.9% sodium chloride.

The primary purpose of this study is to evaluate the feasibility of delivering a combined nutritional and exercise intervention in patients with inoperable gastrointestinal (GI) or lung cancer, who are at risk of developing cancer cachexia. The ultimate aim is to determine whether the combined intervention prevents or slows progression of cancer cachexia, and improves performance status, nutritional status, and quality of life. Who is it for? You may be eligible to join this study if you are aged 18 or over, have advanced incurable upper gastrointestinal cancer (including gastric, pancreatic, biliary), or lung cancer, and a BMI of 20 or higher. Study details Participants in this study will be randomly chosen (by chance) to receive either standard treatment or the nutrition and exercise intervention program. The program involves completing two supervised 1 hour strength-based exercise sessions per week, taking a high protein nutritional supplement drink after each exercise session and taking daily fish oil supplement tablets. The program will last for 12 weeks. Outcomes will be measured at 6 weeks and 12 weeks into the program, and at 6 months. Participants will complete a number of questionnaires, will be asked to keep a 3-day food diary and complete strength and walking tests. It is hoped that the findings of this study will provide information on the efficacy and feasibility of the nutrition and exercise intervention in cancer patients, with the hope that it will slow or prevent the development of cachexia in these individuals.

The aim of this study is to assess whether two different doses of antenatal intravenous iron administration (500 mg and 1000mg ferric carboxymaltose) are equivalent in replenishing and sustaining iron stores successfully in pregnant iron deficient women.

This study comprises part of a PhD project. It aims to identify what are the primary mechanisms responsible for muscle growth following light-load blood-flow restriction training in the legs, and how it can also affect muscles in other limbs. This will be compared with an equal-intensity training group without blood-flow restriction, a heavy-load resistance training group, and an untrained control group. This will be investigated using a seven week strength training study.

A family of receptors in the gut recognises all known sweet tasting molecules, including glucose. We, and others, have shown that activation of these ‘sweet taste receptors’ triggers a series of events, mediated by gut hormones, which coordinate the absorption and metabolism of glucose, increasing the capacity for both. These gut hormones increase insulin release in the presence of glucose, and increase levels and function of the major gut glucose transporter, sodium-glucose co-transporter 1 (SGLT-1). Accordingly, the activation status of gut sweet taste receptors has the potential for substantial influence on the control of blood glucose. Patients with type 2 diabetes have increased capacity for glucose absorption from their gut, a trait which can worsen their blood glucose control, and increase disease progression. We recently published important data showing that sweet taste receptors in the duodenum were abnormal in patients with type 2 diabetes during high blood glucose, in association with increased glucose absorption. Blocking duodenal sweet taste receptors is known to reduce the release of gut hormones linked to increases in the glucose transporter SGLT-1 in both rodents and humans, however, it is unknown whether blocking sweet taste receptors in patients with type 2 diabetes can reduce glucose transporter function and, therein, glucose absorption, as a new approach to therapy. We now plan to test the effects of the sweet taste receptor blocker, lactisole, on blood glucose control in patients with type 2 diabetes following a glucose infusion.

Anxiety disorders are the most common mental disorder in children with 1 in 5 experiencing an anxiety disorder before adulthood. The Centre for Emotional Health at Macquarie University has developed a program, Cool Kids, which is effective in treating these disorders. Improving access to care is an essential next-step in the dissemination of effective treatments for anxiety disorders – particularly in Australia, given the vast regional and remote areas. We will conduct a randomized clinical trial comparing treatment to waitlist conditions to evaluate the efficacy of the Cool Kids program delivered online for the treatment of anxiety disorders in young people. The project hypotheses are as follows: 1) the Cool Kids Online program will produce significantly better outcomes than waitlist control (no treatment) on anxiety diagnoses, symptoms and life interference, 2) treatment gains following the Cool Kids Online program will be maintained over a six month follow-up period, and 3) families completing the Cool Kids Online program will report high levels of treatment satisfaction.

Sleep is an essential biological function which is required by all animal. The Intensive Care Unit (ICU) environment fails to be propitious for sleep, which has been attributed to immediate and long term physiological and psychological morbidities. It is widely acknowledge that sleep is critical for ICU patients’ recovery, however the ability to monitor and evaluate sleep amongst this patient cohort has eluded clinicians. Bio-physiological monitoring of sleep undertaken via polysomnography is not viable for widespread implementation into intensive care as it is cumbersome, expensive, technically difficult, and requires expertise in data analysis. However, identifying alternative sleep monitoring methods that are both accurate and feasible have eluded clinicians. The role of sleep is an aspect of clinical care that is imperative to address in order to improve patient health, support physiological homeostasis, and to implement strategies that mitigate the short and long term adverse effects associated with sleep disturbance that complicates patient’s recovery. This study is investigating whether sleep monitoring conducted by actigraphy will provide an accurate objective assessment of total sleep time and sleep fragmentation compared to polysomnography. Objectives: 1.To determine the total sleep time of patients admitted to ICU. 2.Evaluate the sleep architecture of patients admitted to an Australian Intensive Care Unit

Chronic non-specific low back pain and knee osteoarthritis are among the most prevailing chronic pain conditions. Despite the a wide array of treatment options available, not everyone receives satisfactory pain relief. This may be because people respond differently to pain treatments. An optimal and safe treatment is necessary. This project aims to determine whether people with two forms of pain adaptability respond differently to local acupuncture needling. We test this aim in people with knee osteoarthritis or low back pain. The pain adaptability of the participants has previously been determined using a cold pressor test. The acupuncturist is blinded from participants’ pain adaptability and delivers an acupuncture treatment of 8 sessions. The response to acupuncture is measured by assessing the change in pain at the knee or lower back through a pain diary before and after the acupuncture treatment. This project will contribute to the development of individualised medicine by targeting those who respond better to acupuncture.