ANZCTR search results

To determine if: Patients who obtain and participate in a home exercise program received via 2 home visits, in addition to group exercise will experience greater improvements in balance than participants who participate in the group program and are given a home exercise program at the hospital (normal care).

The purpose of the proposed project is to conduct a pilot study of the acceptability, efficacy and feasibility of a low-intensity internet-delivered CBT (iCBT) self-management program, the Chronic Conditions Course, in reducing symptoms of anxiety and depression adults with functional gastrointestinal disorders. The proposed trial employs a single-group open-trial design (n = 30) and participants will be given access to an internet-delivered CBT Course; a 5-lesson 8 week self-management program. Participants will have brief weekly contact with a Clinical Psychologist as they work through the Course.

The purpose of this study is to assess if melanoma prevention behaviours can be improved by providing individuals with personalised melanoma risk information and prevention recommendations based on their level of risk. Who is it for? You may be eligible to join this study if you are aged 18 years or above and have the capacity to give informed consent in English. Study details Participants in this study will be randomly (by chance) allocated to one of two groups. Participants in both groups will receive general prevention information on melanoma. One group will then additionally receive personalised melanoma risk information and prevention recommendations based on their risk levels. Risk levels will be based on self-assessed melanoma information. Participants will be assessed on melanoma risk perceptions, melanoma risk reduction intentions and melanoma prevention behaviours 6 and 12 weeks after the intervention by follow up questionnaire. This research will help determine if providing individual melanoma risk information improves melanoma prevention behaviours in healthy adults.

Few studies have compared sitting on a standard ergonomic chair with working on a sit-stand desk in terms of health benefits. In terms of broader cardio-metabolic benefits of alternative office working modes, research on standing is particularly scarce and the very few studies that examined how cardiometabolic blood biomarkers respond to replacements of sitting were done in laboratory conditions that are not necessarily translatable in real-life office environments. Very little evidence exists on how changes in work time sitting influences fatigue, and mood, or after work hours physical activity and sedentary behavior. The objectives of this pilot intervention are to examine: The acceptability of and adherence to different sitting-standing protocols to participants b) The impact of the different sitting-standing protocols on participants’ outcome measures (see below) c) The acceptability of and adherence to data collection procedures such as taking blood samples and wearing an inclinometer for 7days (24hrs a day), and a kinematic sensor for 2 days. This pilot study will provide valuable information on planning for a larger randomised controlled trial which will examine the effects of different sitting-standing modes on the health of office workers.

The primary purpose of this study is to determine whether ASN-002 alone or in combination with 5-FUis safe and effective in the treatment of nodular basal cell carcinoma (nBCC). Who is it for? You may be eligible to join this study if you are aged 18 or over, have been diagnosed with nBCC. Study details ASN-002 is a vaccine-like product that is injected into the BCC spot to be treated. It is made from modified adenovirus serotype 5 (also called Ad5). Adenoviruses are common in nature worldwide and can cause mild colds and respiratory infections from which people usually recover without treatment. The Ad5 used in this study has been modified so that it cannot grow in the body or cause an infection. The modified Ad5 in this study will deliver artificially made genetic material into the cancerous and surrounding cells. This genetic material will produce human interferon which is normally produced by the body to stimulate the immune system. It is hoped that injected ASN-002 will cause the body’s own cells to produce interferon and stimulate the immune system to attack the cancerous cells and reduce the size of or eliminate the nBCC. 5-FU is a chemotherapeutic agent approved to treat many types of cancer. Participants will attend the study centre weekly for an injection of ASN-002 alone or in combination with 5-FU into the nBCC. The participants recruited will have 3 injections over 3 weeks, and then undergo surgical excision of the tumour. Patient outcomes will then be assessed using a tumour sample collected during surgery and by the incidence of adverse events which occur throughout the study. It is hoped that the findings of this trial will provide information on the safety and efficacy of using ASN-002 alone and in combination with 5-FU for nBCC, particularly for patients in whom the standard treatment of surgery is not possible or not recommended.

This study aims to find out if this evidence-based alternative to the traditional use of triaged waiting lists reduces waiting time for a variety of community health and sub-acute ambulatory care services. It is hypothesised that this will be achieved without detrimental effects on service quality, patient outcomes, patient satisfaction or service cost.

A randomised controlled trial will be used to investigate the effectiveness of the iChooseWell program. The iChooseWell program will be placed within the Federation eHealth Platform. People visiting the website, in response to advertisements or through self interest, will be informed of the availability of the iChooseWell program and invited to participate in the study. People who consent to take part in the study will be randomly allocated to either an immediate access to the program condition or a delayed access condition (8 week delay). The iChooseWell eHealth program consists of forty biological, psychological, social, and wellness strategies, all designed to increase mind and body health (e.g., brain & gut nutrition, emotional regulation strategies, problem solving, sleep hygiene, social connectedness, practising gratitude). Participants will be able to choose from the array of biopsychosocial strategies available within iChooseWell. Background information is also provided on health and wellbeing (e.g., the stress response, brain/neural plasticity) and useful resources are provided (e.g., self monitoring, ‘On the Go’ mobile tools). Each individual wellness strategy is 2-6 web pages in length (taking between 5-20 minutes to read) and its user friendly and interactive components are designed to keep the user engaged. To consolidate learning, participants will be given activities (10 minutes per day on average) to complete offline to practise the principles of the chosen wellness strategies. Participants will also receive automated emails (e.g., to remind them to log on, when to complete post/follow-up questionnaires) and will be asked several questions during the study period to monitor their progress. The iChooseWell program includes text, graphics, audio, video, quizzes, and downloads. iChooseWell can be accessible via web, mobile or tablet devices. Participants randomised to the iChooseWell eHealth immediate access group will complete a pre-intervention assessment (Week 0), during intervention (Week 3) assessment, post-intervention assessment (Week 5) and a 1 and 3 month follow-up assessment (Week 9 and Week 17). Participants randomised to the delayed access group will complete the same assessment phases and will be given access to the iChooseWell eHealth program following the 1 month follow-up assessment (Week 9). However the delayed access group will be asked to complete the post intervention assessment after they have completed the iChooseWell program (Week 13) and a 1 month follow-up (post program) (Week 17). Access to iChooseWell will be provided for the entire trial period. Adherence will be measured by the number of strategies visited by post assessment (measured via passive analytics) as well as questions regarding engagement levels. It is expected that people who undertake iChooseWell will show increases in mental health and wellbeing and optimism and reductions in negative affect at post and the 1 month follow-up time points.

A comparison of two commonly used methods for securing intravenous cannulas Objective: There is a wide variety of techniques to secure intravenous cannulas but little objective evidence to support their relative efficacy. This study compares the security of the two most common methods used within a major Australian Emergency Department. Methods: The plastic sheaths of four needle-less intravenous cannulas were secured to the skin surface (not intravenously) of 40 volunteers using two different taping styles, an ‘under and over’ method with one of the tapes applied to the posterior surface of the hub then crossed anteriorly to adhere to the opposite skin surface or ‘horizontal’ taping with the tapes applied horizontally across the anterior surface of the hub. The peak force required to dislodge the taped cannulas using each of these different methods was then measured in both an anterograde and retrograde direction of force using a force transducer. In more detail, the force of dislodgement was measured in antergrade and retrograde directions with a force transducer and these forces compared. The "under and over" technique was the intervention arm being compared to the more standard "two horizontal tape" method. The plastic sheaths of four needle-less intravenous cannulae were secured to the skin surface (not intravenously) using an ‘under and over’ method with one of the tapes applied to the posterior surface of the hub then crossed anteriorly to adhere to the opposite skin surface or ‘horizontal’ taping with the tapes applied horizontally across the anterior surface of the hub. The peak force required to dislodge the taped cannulae using each of these different methods was then measured in both an anterograde and retrograde direction of force using a force transducer. Each participant had two cannulae for each of the two techniques ie four cannulae in total. The cannulae were applied sequentially to the cubital fossae (2 per arm)of the body. The first cannula was placed in one cubital fossa using the control technique and removed in an anterograde fashion, followed by the second cannula on the same cubital fossa utilising the intervention technique, again dislodged using anterograde force. The process was repeated on the opposite cubital fossa using retrograde force. Cannulae were left in place 5 mins before removal and there was approximately five minutes again until the next cannula removal. Anterograde / retrograde removal is defined as the hub is pulled in direction of cannula removal (anterograde) and against the direction of removal (retrograde) until dislodged. A senior clinician grade operator (often PI) applies the force transducer to the cannula hub whilst blinded to the technique utilised. A second senior clinician grade applies the cannulae without revealing this to the operator attempting removal. There were no adherence monitoring process applied. Results: The force required to dislodge a cannula taped in an ‘under and over’ taping style was significantly higher than that required for the horizontal taping in both anterograde and retrograde directions of force. (p <0.001) Conclusion: The results of this study suggest that the ‘under and over’ taping technique offers significantly more security than ‘horizontal’ taping and should be considered as a more effective method for securing intravenous cannulas.

Exercise is an integral component of the conservative management of most musculoskeletal conditions. However, adherence to exercises is often low and this impacts on treatment effectiveness. The aim of this randomised controlled trial is to evaluate whether the addition of a web-based system, Physitrack, to usual physiotherapy treatment improves patient adherence levels to exercises compared to the usual non web-based methods physiotherapists use to deliver exercise programs to people with musculoskeletal conditions. Secondary aims are to evaluate whether Physitrack improves patient satisfaction with the delivery of an exercise program and whether patient confidence changes with Physitrack. The primary hypothesis is: The level of patient-reported adherence to a prescribed exercise program will be greater in the group receiving Physitrack in addition to usual physiotherapy treatment (Physitrack group) than in the group receiving non web-based usual physiotherapy treatment alone (Usual care group) after 3 weeks. Secondary hypotheses are: i) The level of patient satisfaction with the delivery of the prescribed exercise program will be greater in the Physitrack group than in the group receiving non web-based usual care after 3 weeks; and ii) The level of patient confidence with exercises will be greater in the Physitrack group than in the group receiving non web-based usual care after 3 weeks.

The aim of this study is to determine if the Mediterranean Diet (MD) compared to standard care (low fat diet), can reduce the severity of NAFLD and other symptoms often associated with NAFLD namely the Metabolic Syndrome (MetS). The components of the MetS which this study aims to monitor and potentially reduce includes: high blood pressure, increased waist circumference, elevated triglycerides (bad fats in the blood), reduced HDL cholesterol (good fats in the blood) and elevated glucose levels. These symptoms are referred to as the Metabolic Syndrome (MS).