ANZCTR search results

The primary purpose of this study is to examine the safety and potential effectiveness of a drug molecule called 64Cu-SARTATE as a potential new way to detect neuroendocrine cancers. Who is it for? You may be eligible to join this study if you are aged 18 years or over, have a life expectancy of 8 weeks or more and Low and Intermediate Grade (Ki-67 index <20%) neuroendocrine tumors (NET). Study details: All participants in this study will be injected with a single dose of 64Cu-SARTATE (a drug molecule). The study lasts for one week and the patient is administered 1 dose of the drug followed by whole body PET scans at 30mins, 1hr, 4hrs, & 24hrs. Complete safety evaluations will occur during visit 2 (day 2) & visit 3 (day 8). These scans will be compared to the current PET imaging standard called 68Ga-DOTATATE which you will have recently received as a standard procedure. It is hoped that this research will help to develop a product which is more accurate for the diagnosis of neuroendocrine tumours in patients.

This study is investigating the feasibility of providing a direct measure of lung tumour motion during radiotherapy treatment, using existing standard treatment equipment. Who is it for? You may be eligible to join this study if you are aged 18 years or above, have been diagnosed with lung cancer and are a Patient with non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC). Study details All patients in this study undergoing radiotherapy will have markers implanted into and around lung tumours using an airway ultrasound technique known as Endoscopic Bronchial Ultrasound (EBUS). The procedure has a duration of about 45 minutes. Then patients wait 2 weeks before continuing to routine radiotherapy simulation and planning. Treatment planning typically takes 2-3 weeks and then treatment will commence. The inserted markers are visualised and tracked using x-ray images, during the radiotherapy treatment sessions, once a week. This study aims to validate a method to record real-time tumour motion due to respiration, during lung cancer radiotherapy treatment. Identifying the motion in real-time will help to implement treatments that can track tumours, resulting in safer and more effective treatments.

This trial will aim to determine if smartphone based Motivational Interviewing supplemented with Motivational Interviewing provided during usual physiotherapy care can increase activity in patients with sub-acute low back pain.

Non-invasive brain stimulation is emerging as a therapeutic tool for many brain related conditions. There are numerous non-invasive brain stimulation techniques that apply electrical or electromagnetic stimulation to the brain in different ways to alter neural activity. The most researched, and consequently best developed, of these are transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). Both TMS and tDCS has been shown to have varying degrees of therapeutic efficacy for major depression. Research efforts are currently focused on identifying factors that modulate individual differences in the way the brain response to TMS which could lead to development of optimised protocols for stimulation delivery. There is evidence that sex hormones may modulate the effect of TMS and tDCS. However very few studies have investigated this and none have focused on the dorsolateral prefrontal cortex, the site that both methods are most often applied in a clinical context. The current project is an investigation of the impact of gender, and within female gender of menstrual phases associated with high and low estrogen, on the effect of TMS and tDCS to the dorsolateral prefrontal cortex.

The purpose of this study is to investigate whether our standard practice of injecting local anaesthetic into the knee joint for total knee replacements impacts knee range of motion at 6 weeks post operation for total knee replacement. We hypothesize that local infiltration analgesia during operation in total knee replacements negatively impacts the knee range of motion.

The transbronchial lung cryobiopsy is a new, minimally invasive technique for obtaining lung tissue to diagnose ILD. In order to determine the place of cryobiopsy in ILD diagnostic algorithms and international guidelines, it is crucial that this procedure is validated against the current gold-standard practice, the VATS biopsy. This study brings together a team of leading proceduralists, ILD specialists and histopathologists from across Australia, with consultative input from international leaders in the field. The main objective of this project is to determine the role of cryobiopsy in the diagnosis of ILD.

Men who have sex with men tested positive for pharyngeal gonorrhoea at Melbourne Sexual Health Centre (MSHC) who volunteer will be randomised to receive an alcohol-containing mouthwash or a saline on the day when they receive treatment for pharyngeal gonorrhoea. The primary outcome is the proportion of cases who test positive for pharyngeal gonorrhoea by culture after gargling an alcohol-containing mouthwash.

to test the feasibility and acceptability of HOW R U, an innovative volunteer-peer telephone-support intervention designed to support older vulnerable people after hospitalisation with the aim of improving their quality of life and reducing their risk of avoidable re-attendance and hospitalisation. Hypothesis: Volunteer-peer telephone-support will help reduce symptoms of social isolation, loneliness and depressive feelings, through an improvement in mood and quality of life.

Up to 80% of Australians experience back pain and 10% have significant disability as a result. There is a critical need for the development and evaluation of innovative treatments that have the capacity to target the multidimensional nature of chronic low back pain. This study will compare the effects and mechanisms of Mindfulness Meditation, Cognitive Therapy, and Mindfulness-Based Cognitive Therapy for chronic low back pain. Results will ultimately lead to streamlined interventions designed to efficiently maximise benefit.

The primary objective of this study is demonstrating the performance and safety of EvokeTM spinal cord stimulation with feedback control on neural stimulation in patients with chronic pain with regard to pain relief and stimulation side effects. A new technique has been developed to measure Evoked Compound Action Potentials (ECAPs) or neural responses to neural stimulation, on the same lead that delivers the stimulation. This research will help advance neurostimulation technology.