ANZCTR search results

These search results are from the Australian New Zealand Clinical Trials Registry (ANZCTR).

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31346 results sorted by trial registration date.
  • Gum Elastic Bougie vs The Frova Airway Intubating Catheter when using the Glidescope for difficult intubation

    Background: A ‘bougie’ may be less traumatic than the GlideScope-specific intubating stylet during videolaryngoscopy-guided intubation, but no comparative studies of bougies have been performed. Objective: To compare the Portex tracheal tube introducer (PTTI) and Frova intubating introducer (FII) used with the GlideScope videolaryngoscope in simulated difficult intubation.

  • Randomised Controlled Evaluation of a Complex Intervention (Education and Logistical Strategies) to Promote Uptake of School-based Human Papillomavirus Vaccination among adolescents in a School-Based Program

    The study is evaluating the effect of a complex intervention including education and logistical strategies, to promote uptake of school-based Human Papillomavirus (HPV) vaccination among adolescents in the Australian national School-Based Vaccination Program. Who is it for? We will recruit a random sample of Australian secondary schools to be part of this study; adolescents in these schools who are offered HPV vaccine as part of the national school vaccination program have the option to participate in our study. Trial details Schools participating in this trial will be randomly (by chance) divided into one of two groups. Schools who are in one group will deliver a complex intervention for promoting the uptake of the HPV vaccination among adolescents in a school-based program which consists of an adolescent intervention, a parent/adolescent decision aid, and logistical strategies. Prior to the first dose of the HPV vaccination, education is delivered by school personnel through the school in an interactive session. An educational magazine is given to students as take-home information designed by and for adolescents; a website and app providing information for students to access in and outside of school; and distraction/relaxation app for students to be used on vaccination day. A parent/adolescent HPV Decision Aid or a brief HPV information resource for parents and adolescents to use together is delivered to parents and adolescents at the time of the vaccination consent form. Logistical strategies include 1) guidelines for nurses and teachers regarding set-up of the vaccination room; 2) strategies to promote improved consent form return (reminders, direct mail-out to parents, incentives e.g. Classroom consent form return); 3) up to one additional vaccination visit to deliver mop-up vaccination to students incompletely vaccinated. Participants in the second group will receive the standard national school-based HPV vaccination program that takes place across all jurisdictions. This includes government funded HPV vaccination (three doses) for adolescents after parental/guardian consent has been granted. As part of this process parents/guardians receive a standard government brochure that provides information about HPV and HPV vaccination, and nurses follow standard state health department policy for delivery of vaccine in schools.

  • A randomised controlled video vignette study on the effect different timing and lengths of discharge summaries have on the ability of general practitioners to identify ongoing problems in patients recently discharged from the hospital.

    General practitioners (GPs) were randomised into four groups. Each viewed a video monologue of an actor-patient as he might present to his GP following a hospital admission with ten problems. GPs were provided with a medical record as well as a long or short discharge letter, which was available at time of viewing the video or one week later. GPs indicated if they would prescribe, refer, or order tests for the patient’s problems.A short or long hospital discharge summary enumerating the patient’s problems. Intervention: Discharge summary available at time of consultation or a week later. To determine the relationship between the timing and length of hospital discharge letters and the identification of ongoing patient problems by GPs Number of ongoing patient problems identified for management by the GPs.

  • An evaluation of the necessity for physiotherapy intervention for patients with isolated hand/forearm burns treated conservatively or with Biobrane.

    Given that the recovery of patients with isolated hand burns that were able to be managed conservatively or with Biobrane has been shown to be rapid and the amount of physiotherapy intervention required was relatively low, it raises the question of whether any physiotherapy intervention is actually required. Could the same rapid recovery be seen with natural recovery and no physiotherapy intervention? In a healthcare setting where resources (e.g. time, staffing) are always a major consideration, the ability to focus our physiotherapy interventions on those patients who actually require these is essential. Therefore, the aim of the current study is to compare outcomes between those patients who receive standard physiotherapy and those who receive no physiotherapy in patients with isolated hand/forearm burns that are able to be treated conservatively or with Biobrane.

  • A Randomized, Single-Blind, Single-Dose, 3-Arm, Parallel Group Study to Determine the Pharmacokinetic Equivalence of ABP 980 and Trastuzumab (Herceptin "(Registered Trademark)" ) in Healthy Male Subjects

    The study is evaluating the safety, tolerability, and immunogenicity of ABP 980 in healthy subjects compared with US Food and Drug Administration (FDA)-licensed trastuzumab and European Union (EU)-authorized trastuzumab. Who is it for? You may be eligible to join this study if you are healthy male, aged between 18 to 45 years of age (inclusive), and have a body mass index between 18.0 and 30.0 kg/m2 (inclusive) for non-Japanese subjects. To be enrolled as a Japanese subject, subjects must be either first- or second-generation Japanese and have a body mass index between 18.0 and 25.0 kg/m2. Trial details Participants in this study will be randomly (by chance) divided into one of three groups. Participants in one group will receive 6mg/kg of ABP 980 (440mg vial) intravenously once only. Participants in the second group will receive 6mg/kg2 of FDA-licensed trastuzumab (440mg vial) intravenously. Participants in the third group will receive 6mg/kg2 of EU-authorised trastuzumab (440mg vial) intravenously. All participants will be followed-up at 64 days post allocation to one of the three drugs used in this trial. Address: Nucleus Network Limited Centre for Clinical Studies (AMREP site) Level 5 Burnet Building 89 Commercial Road, Melbourne, Victoria 3004

  • INTEGERATE: Is Integrated Geriatric Assessment and Treatment Effective in older adults with cancer receiving cytotoxic chemotherapy, targeted therapy or immunotherapy? A Randomised Controlled Study

    The purpose of this study is to determine if integrated oncogeriatric care improves outcome in older patients who are receiving chemotherapy for cancer. Who is it for? You may be eligible to join this study if you are aged 70 years or above, have been diagnosed with cancer and are about to start chemotherapy (this includes cytotoxic chemotherapy, targeted therapy or immunotherapy). Study details. Participants in this study will be randomly (by chance) allocated to one of two treatment groups. Participants in one group will receive integrated oncogeriatric care. In addition to seeing their oncology doctors, participants receiving integrated oncogeriatric care will also have a comprehensive assessment and management by a geriatrician to identify problems early on and help co-ordinate care to support patients, their carers and their families better. Participants in the other group will receive standard oncology care and continue to see their oncology doctors for treatment of their cancer. Participants will be regularly assessed over 24 weeks by questionnaires to determine whether integrated oncogeriatric care improves quality of life, function, mood, nutrition, chemotherapy delivery, healthcare utilisation and healthcare costs.

  • Corticosteroid, Autologous blood or Polidocanol injections guided by ultrasound in the management of tennis elbow: a randomised clinical pilot trial. (The CAP trial)

    This study aims to compare the efficacy of corticosteroid vs. autologous blood vs. sclerosant injection for the treatment of tennis elbow in order to see which treatment modality incurs the most benefit.

  • The implementation of effective non-pharmacological interventions of the People Getting a Grip educational program for individuals with rheumatoid arthritis through different delivery methods: An International Online Knowledge Translation Randomized Controlled Trial

    With an aging population and a greater number of individuals with modifiable risk factors for established chronic diseases such as arthritis, there is an urgent need for co-care management (pharmacological as well as non-pharmacological) of arthritic conditions. Patients with RA need ready access to effective self-management programs to increase patient optimize their quality of life, reduce the burden on the limited number health professionals in both Canadian and Australian health systems, especially in rural locations. A major issue in health research today is finding effective and efficient ways to exchange knowledge between researchers, health professionals and the general public, including people with arthritis. Facebook a popular social networking site which allows friends, family and business associates to connect with one another, appears to be best suited to explore as a KT strategy. Facebook has been shown to be a successful tool in recruiting and communicating with a research team, even in a multinational context. The use of Facebook as a KT medium to disseminate information from the bilingual evidence-based educational program: People Getting a Grip on Arthritis (PGrip) (Copyright) is a promising strategy to improve the health of patients with arthritis in an effective and cost-effective manner. The involvement of health professionals in patient education can allow patients with arthritis to be managed efficiently, resulting in reduced wait times for care.

  • Is two days of intermittent fasting per week a feasible weight loss approach in obese male war veterans? A pilot study.

    This pilot study aims to determine whether the intermittent fasting approach leads to greater weight loss and greater improvements in blood sugar, cholesterol and blood pressure than a standard low energy diet in obese male war veterans. Our primary objective is to determine whether obese, male war veterans who undertake intermittent fasting (5:2 method) achieve at least 5% weight loss in six months.

  • Prediction of your marathon time from a treadmill test

    This study was conducted to investigate the relationship between graded treadmill test to exhaustion and marathon time two weeks later. The aim was to see if a treadmill test could predict upcoming marathon time to help the athlete with pacing and preparation for their marathon.

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