ANZCTR search results

This study will determine the effectiveness of a lifestyle intervention designed to minimise anti-psychotic induced weight gain for young people experiencing first episode psychosis.

Newborn intensive care provides life-saving mechanical ventilation when the lungs of a very ill baby deteriorate with illness and need assistance to provide blood oxygen and removal of blood carbon dioxide. This involves the routine placement of a soft plastic tube called an endotracheal tube into the main breathing passageway called the trachea. This tube is placed via the nose or the mouth and mediations are used to relax the baby to ensure the procedure occurs with minimal disturbance. With these medications, the medical staff will provide breaths with a mask placed over the mouth and nose. There are two recognized ways of holding the mask. In both methods some leak of the breath provided occurs around the mask and occasionally a degree of obstruction occurs. This study seeks to determine which method is better. These methods are; where one person holds the mask in place with one hand and provides breaths with the other hand compared to the other method where one person holds the mask and another person provides the breaths. The purpose is to investigate whether by using a two-person method for mask ventilation; we are able to reduce the leak and airway obstruction so that the ventilation is more effective.

The purposes of this study are to (1) identify the needs of adults (18 yr. and older) with depressive symptoms in relation to a web-based physical activity intervention, and (2) test the feasibility of a web-based physical activity intervention for people with depressive symptoms.

The primary purpose of this study on healthy volunteers is to determine the safety and tolerability of MRX-I, an orally administered antibiotic. There will be three Parts to the study. Part 1 will assess the safety, tolerability and pharmacokinetics of single dose administrations of MRX-I compared with placebo. Part 2 will assess the safety, tolerability and pharmacokinetics of a 14 day administration of MRX-I compared with placebo. Part 3 will compare the safety and tolerability of a 28 day administration of MRX-I with linezolid an active comparator. (please reference ACTRN12613001206718)

The primary purpose of this study on healthy volunteers is to determine the safety and tolerability of MRX-I, an orally administered antibiotic. There will be three Parts to the study. Part 1 will assess the safety, tolerability and pharmacokinetics of single dose administrations of MRX-I compared with placebo. Part 2 will assess the safety, tolerability and pharmacokinetics of a 14 day administration of MRX-I compared with placebo. Part 3 will compare the safety and tolerability of a 28 day administration of MRX-I with linezolid an active comparator. (please refer to ACTRN12613001206718)

Eosinophilic oesophagitis (EOE) is a recently discovered condition which involves allergic inflammation in the oesophagus. This research project aims to conduct the first study of a dietary intervention for the treatment of EOE in children. As part of the research we also aim to mechanistic studies into the pathophysiology of this condition. This study is being completed in two stages. In Stage 1, children with suspected EOE undergoing gastroscopy will be invited to take part into the study. Only patients with confirmed EOE will progress to stage 2 of the study. In Stage 2, children with confirmed EOE will be randomly allocated to one of two interventions: four-food elimination diet (avoiding cow's milk, egg, soy and wheat) plus omeprazole, versus omeprazole alone as the control intervention (for 8 -12 weeks in each arm of the study).

At least a third of people with eating disorders bulimia nervosa or binge eating disorder will be overweight. However, therapies for such disorders do not address weight management well. Similarly, treatments for obesity do not address the eating disorder symptoms , and whilst there may be short term reductions in binge eating with weight loss therapy this is not sustained over time. We have developed an approach that integrates standard cognitive behaviour therapy (CBT) for eating disorders with behavioural weight loss management adapted for this group i.e. HAPIFED. The present study is a preliminary controlled trial of HAPIFED versus CBT.

The study is evaluating whether testing for certain types of Human Papillomavirus (HPV) is a more effective cervical cancer screening test than the Pap Smear test. Who is it for? You may be eligible to join this study if you are female, aged between 25 years and 64 years, an Australian resident in Victoria, and attends routine cervical screenings at one of the study’s participating health care practice. Trial details Participants in this study will be randomly (by chance) divided into one of three groups. Participants in one group will undergo three-yearly image read cytology screening with reflex HPV triage testing for low grade Possible/Definite Low-Grade Squamous Intraepithelial Lesion (p/d LSIL) smears. Participants in the second group will undergo six-yearly HPV screening with types 16/18 (+/- 45 in pilot study) genotyping and cytology triage of intermediate risk women with other oncogenic HPV infection. Participants in the third group will undergo a six-yearly HPV screening with types 16/18 (+/- 45 in pilot study) genotyping and dual-stained (DS) cytology (with p16/Ki67) triage of intermediate risk women with other oncogenic HPV infection.

The primary purpose of this study on healthy volunteers is to determine the safety and tolerability of MRX-I, an orally administered antibiotic. There will be three Parts to the study. Part 1 will assess the safety, tolerability and pharmacokinetics of single dose administrations of MRX-I compared with placebo. Part 2 will assess the safety, tolerability and pharmacokinetics of a 14 day administration of MRX-I compared with placebo. Part 3 will compare the safety and tolerability of a 28 day administration of MRX-I with linezolid an active comparator.

Frail older people living in residential care are often prescribed unnecessary medications. We want to test whether stopping some of their drugs will improve their life expectancy, quality of life & independence & reduce their risk of falling. We will stop medications thought to cause harm in older people and medications that may not provide any overall benefit. The primary aim is to determine whether deprescribing is safe among older people living in residential aged care facilities (RACF). The secondary aims are to determine whether medication reduction improves physical health, cognitive function, and quality of life.