ANZCTR search results

An observational, questionnaire based study in which the effectiveness of DRG stimulation as a treatment for chronic low back pain will be assessed in patients routinely scheduled for this treatment

The World Health Organisation has highlighted the importance of preventing weight gain in adults who are of healthy weight and women of reproductive age are a key population to target. Overweight and obesity (defined as a body mass index of 25kg/m2 or more) is a significant health problem, associated with many adverse health outcomes. High rates of weight gain during pregnancy increases the risk of becoming overweight, as it may difficult to lose excess weight gained in pregnancy. It is estimated that approximately 60% of women have high degrees of weight gain during pregnancy, which in turn is recognised as a significant risk factor for adverse maternal and infant outcomes during pregnancy and childbirth. Women with high weight gain during pregnancy are at increased risk of developing diabetes and heart disease as they get older and are more likely to retain weight after they give birth increasing the likelihood that they will commence subsequent pregnancies overweight or obese.  High pregnancy weight gain is a well-recognised risk factor for high infant birth weight (also call macrosomia), and is associated with an increased risk of pre-school obesity. This study is a randomised trial; women will be randomly allocated to receive access to dietary advice (including access to a qualified dietitian throughout pregnancy, to help you adopt a healthy diet and lifestyle) or continue to receive standard antenatal care which does not usually include access to lifestyle advice from a dietitian. The aims of the OPTIMISE Randomised Trial are to evaluate the effects of dietary, lifestyle and exercise advice to optimise gestational weight gain on maternal, fetal and infant health outcomes, among pregnant women of normal body mass index.

The primary purpose of the study is to analyze the effects of topical tranexamic acid in total knee arthroplasty and to compare it with intravenous tranexamic acid. The study is based on the hypothesis that toipical/intrarticular tranexamic acid is more not inferior in reducing blood loss in total knee arthroplasty and is safer as compared to intravenous total knee arthroplasty.

This is a 12 month single blinded parallel randomised controlled trial with 3 arms: control (usual care), intervention (multidisciplinary lifestyle support). A 3rd arm comprises intervention + a food supplement . Participants will be randomised into a control or one of the intervention groups testing the effect of a novel versus conventional form of individualised health care targeting diet, exercise and health behaviour. An additional 12 month long term follow-up will be offered to all participants. Consenting participants will attend quarterly visits with a dietitian

The purpose of this study is to see if general exercise and education are helpful for patients who have had pelvic cancer (colorectal cancer, gynaecological cancer, or urological cancer). Who is it for? Patients may be eligible to join this study if they are aged 18 - 85 years, have undergone surgery for stage I – III pelvic cancer, and are able to walk and manage self-care, out of bed more than 50% of waking hours (Eastern Cooperative Oncology Group performance status 0 – 2). Trial details All eligible patients will be invited to join the general exercise and education group 6 weeks after all their surgical and medical treatments are finished. The general multidisciplinary rehabilitation will consist of a group education and exercise program, which will be provided twice weekly for 8 weeks. Each session will last approximately one hour. The education component will include advice about nutrition, exercise, fatigue management, health behavior change, and coping with stress. Information will be delivered by a range of clinicians (physiotherapists, occupational therapists, psychologists, and dieticians). The exercise component will include a general (combined aerobic and resistance) exercise training program supervised by a physiotherapist. All participants will be required to complete some questionnaires and tests (e.g. six-minute walk test, shuttle walk test etc) at the end of the intervention, and at 6, 12, 24 and 60 months from baseline.

A group-randomised controlled trial of a parenting intervention aimed to improve parenting skills in ways that facilitate the development of emotional competence in youth, and emotional communication in the family, thereby improving youth externalising and internalising difficulties.

This study will use and test a memory training program to improve self-care in patients with heart failure. It is hypothesised that this training will improve memory and heart failure self-care and reduce the number of hospital readmissions

This study examines the role of Magnesium supplementation in depression that is resistant to standard treatment. 10 participants who have a confirmed history of treatment non-response while on Medication will be recruited into this small pilot study. participants will take a 1600mg a day divided Magnesium dose in addition to standard medication treatment for a maximum of 8 weeks following a standard protocol in which participants will be subject to pre and post clinical symptom measures. this study aims to provide a preliminary investigation of the value of Magnesium supplement adjuvant treatment for resistant depression.

This project will investigate the efficacy of providing cognitive flexibility and rule abstraction therapy to six children with atypical phonology at age three, an age at whcih many children are referred to speech pathologists. It is hypothesised that therapy will lead to improvements in cognitive flexibility and rule abstraction, phonology and phonological awareness.

This intervention study will evaluate a discussion-based, patient directed group education program for the management of newly diagnosed type 2 diabetes. The potential benefits of this research for the researchers and other health professionals in the field, include an improved understanding of how best to educate type 2 diabetes patients in a group setting. Additionally, the impact of group interactions and patient-directed or patient-centred care will be assessed. The potential benefits for the participants include an improved understanding of type 2 diabetes, lifestyle improvements, and improvements in self-management behaviours. Participants will have the opportunity to ask any questions to the health professionals facilitating the groups, and to discuss any issues they have relating to their diabetes with both peers and health professionals.