ANZCTR search results

These search results are from the Australian New Zealand Clinical Trials Registry (ANZCTR).

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32712 results sorted by trial registration date.
  • Promoting physical activity after stroke via self management: A feasibility trial

    To determine the feasibility and efficacy of 3 months of self-management support for increasing physical activity in people with mild disability after stroke

  • A randomised, open-label study using continuous glucose monitoring to compare the effects of once a day versus twice a day prednisolone dosing schedule on glycaemic control in people with type 2 diabetes mellitus.

    Steroids are commonly used medications used to treat for inflammatory conditions. They raise glucose levels. In this study, we will test in people with type 2 diabetes whether changing the timing of doses of oral steroids to twice a day administration, compared to the usual morning dosing, produces a more even pattern of glucose levels and less glucose fluctuation. The study will use continuous glucose monitoring to assess glucose patterns before, during and after three days of steroids.

  • Stimulation Therapy to Produce Tears for the Treatment of Dry Eye – Part 2

    The purpose of this study is to demonstrate that neurostimulation increases tear production and improves symptoms of dry eye disease over baseline measurements.

  • A Study to Compare Oral Vitamin D to Placebo for the Prevention of Low Calcium in the Blood after Surgery for the Total Removal of the Thyroid Gland.

    Surgical removal of the thyroid gland is a relatively safe procedure, but can be associated with a number of specific complications. The parathyroid glands are close to the thyroid gland and can be affected by the surgery. These glands help to maintain calcium levels in the blood and damage to these glands from the surgery can result in low blood calcium levels. Low calcium levels can result in tingling, numbness and muscle cramps. The condition is usually treated with Vitamin D and calcium supplements after it occurs and may prolong the length of stay in hospital. Vitamin D is a very important vitamin that helps to control bone and calium metabolism in the body. This study wants to see if by giving Vitamin D before the surgery low calcium levels can be prevented.

  • A Phase I, Randomised, Open Label Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneous Doses of ATL1102 Alone and in Combination with G-CSF in Healthy Volunteers

    Patients with some diseases (e.g some cancers) or donors) may have stem cell mobilization treatments to increase numbers of stem cells released into the blood from bone marrow. These can then be harvested from the blood for the patient to use for replenishment after chemotherapy. Preliminary data in mice and humans support investigating ATL1102 as an agent for mobilising stem cells, in combination with G-CSF. The trial participation period will be approximately six weeks, which includes screening, treatment and post-dose study follow-up. There will be a total of five clinical trial visits per subject.

  • A system of perioperative assessment and management - a new Model of Care

    Currently, patients are required to attend outpatient clinics for face to face assessment of medical conditions by clinical staff prior to elective surgery. It is hypothesised that a computer-assisted smart questionnaire, delivered by phone, will provide information of sufficient quality to allow patients to be assessed by clinicians on the day of surgery, rather than at a separate preoperative hospital visit. A three phase approach to piloting this new process for preoperative assessment is proposed as follows: Phase 1: Phone screening in parallel with standard outpatients visits at LMHS and TQEH. Call centre data marked but not used for patient treatment. Phase 2: Prospective trial of a total of 1,000 patients at TQEH and the RAH. All patients will attend a streamlined outpatient clinic after phone pre-screening Phase 3: A further 1,000 patients at TQEH and the RAH will be screened by telephone and then triaged to either a streamlined outpatient review or bypass out patinet review and assessed by the anaesthetist on day of surgery. In all cases treating anaesthetists will be asked to mark the pre-assessements for errors or omissions.

  • Critical Evaluation of a Targeted Point of Care (POC) ROTEM (Registered Trademark) and Multiplate (Registered Trademark) Guided Coagulation and Haemostasis Management Programme in Severe Trauma and Critical Bleeding

    There is an increasing body of evidence that the adoption of POC guided coagulation and haemostatic management algorithms in the severely injured trauma patient and in critical bleeding results in improved outcomes. We aim to critically evaluate our POC programme at the Gold Coast University Hospital (GCUH).

  • Investigating a novel method to predict weight outcome after a weight loss program

    Amongst people undertaking any weight loss program, there is considerable variation in the amount of weight lost. Many studies have attempted to predict the outcome of weight loss treatments from information about biological, behavioural and psychological factors collected from participants before the start of treatment, but it has been difficult to predict outcomes using current methods. In a previous study conducted in our research group, we examined a statistical method which appeared to be useful in predicting the outcome of a medically supervised very-low-energy diet program using participants’ baseline physical measurements and psychological characteristics. However, further research is required in order to create a tool which will be useful to patients and healthcare providers. The overall aim of this study is to create a statistical model which can accurately predict the result for a person about to start a weight loss program.

  • Oral sucrose for pain relief in children undergoing bladder catheterization.

    This study is to determine if oral sucrose is useful at reducing the pain and distress caused by bladder catheterisation in children. This is a common and important procedure, often required to diagnose urine infections in children, and currently there is no effective, practical methods proven to reduce the pain caused by this procedure.

  • Foot and lower limb complications following the use of extracorporeal membrane oxygenation (ECMO): The FECMO Study. A single centre retrospective observational study.

    What are the rates of foot and lower limb complications following the use of extracorporeal membrane oxygenation (ECMO) in a major Australian tertiary hospital? Our null hypothesis is that the incidence of foot and lower limb complications in patients undergoing ECMO treatment are not different to those reported in the general inpatient population.

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