ANZCTR search results

This study aims to investigate the benefits of a yoga-based exercise program aimed at preventing falls in older people by improving their balance and mobility. The trial will evaluate the effect of a 12-week yoga program on balance and mobility in 54 older people, randomly split between two groups. The intervention group will participate in a twice weekly group-based program of yoga focusing on balance- challenging standing postures. An experienced yoga instructor will deliver the classes. The control group will receive information about falls risk factors and prevention, but will not participate in the classes. We expect that the yoga group participants will show significant improvements in measures of balance and mobility compared to the control group after the 12 week intervention period.

What is the effect of an eight week telerehabilitation exercise program on exercise capacity, physical activity and quality of life in people with COPD compared to usual medical care? We hypothesize that telerehabilitation will increase exercise capacity and physical activity and improve quality of life compared to standard medical care in people with stable COPD. We also hypothesize that people with COPD will be satisfied with the telerehabilitation as an alternative for hospital-based pulmonary rehabilitation.

We aim to evaluate the importance of arthroscopy prior to the osteotomy procedure. This is to supply the surgeon with additional valuable pre-operative data which will establish a better treatment strategy. We will then evaluate patient outcomes following these two procedures. This kind of osteotomy surgery aims to address an uncommon entity - mild hip dysplasia. Evaluation of this unique operation and its outcomes in this type of patient population will be invaluable in further improving patient care. Key research questions: 1. Does PAO carry good long-term outcomes. 2. Is hip arthroscopy considered as a adjunctive procedure prior to PAO

Platelets are cells in the blood that help to stop bleeding. The transfusion of platelets can be an essential and life-saving managment for patients bleeding after surgery or trauma. The purpose of this study is to assess the safety and efficacy of cryopreserved (frozen stored) platelets compared to conventional liquid platelets for the treatment of bleeding in cardiac surgical patients. Hypothesis - That cryopreseved platelets will be at least as effective and safe as conventional liquid stored platelets in the manangment of active bleeding related to surgery.

This is a double-blind, placebo controlled study assessing the antidepressant, antioxidant and anti-inflammatory effects of curcumin in 60 adults suffering from major depression (mild to moderate severity). Participants will be randomly allocated into either a curcumin (BCM-95 'Registered Trademark' - 500mg twice daily) or placebo group and changes in depression, anxiety and general health will be measured over an 8-week period. The aim of this study is also to investigate potential mechanisms of action of curcumin so urine, saliva and blood samples will be collected at the beginning and completion of the study. Levels of cortisol, kynurenine pathway metabolites (measure of inflammation) and oxidative stress markers will be assessed over time.

An online intervention to improve gluten free diet adherence, coping, psychological symptoms and quality of life in adults with coeliac disease. The intervention modules are based on the theory of planned behaviour and cognitive behaviour therapy. It was hypothesised that relative to the waitlist control group the intervention group would evidence greater improvements in gluten free diet adherence, psychological symptoms, and quality of life from baseline to immediate post-intervention.

Retinopathy of prematurity is a common complication of very premature delivery (less than 30 weeks gestation) and without appropriate screening and treatment can lead to retinal detachment and blindness. It is the leading cause of blindness in children. While in the uterus the fetus and the retina is developing in an environment where the partial pressure of oxygen is only 25-35 mmHg. Following premature delivery the retina is then exposed to partial pressures of oxygen of 60 mmHg and above. ROP has been shown to occur as a result of this hyperoxic exposure, and despite tight control on oxygen saturations which has led to a significant reduction in the disease, ROP still occurs in some part due to the fact that the retina is not meant to develop in this hyperoxic environment. Exacerbating this situation is that many of the neonates at most risk of ROP have significant lung disease of prematurity and as a consequence have recurrent episodes of hyper and hypoxia which occur despite attempts at tight control of oxygen delivery. 670nm red light is thought to act on the cytochrome c oxidative pathway (within cells of the body), which reduces the presence and production of oxygen free radicals. 670nm red light has been shown to reduce ROP in a mice and rat animal model. It has been used safely in the treatment of soft tissue injuries and mouth ulcers following radiation treatment and studies are ongoing with its use in diabetic retinopathy and age-related macular degeneration. This study aims to look at whether 670nm red light reduces the incidence of any stage of ROP and the incidence of ROP requiring laser surgery.

The primary aim of this current study was to assess which type of exercise targeted at the hip is effective in people with low back pain. Due to the relationship of reduced hip rotation range of movement and low back pain, patients were included in the study if they displayed reduced hip rotation range of movement. Hip rotation exercises were compared to additional hip stretching and hip strengthening exercises to determine which group would improve in pain and function. A secondary aim of this study was also to investigate whether an increase in hip rotation range of movement positively correlated to an improvement in low back pain outcomes.

We are doing this study to determine the most effective medication for treating women who have a miscarriage during the first three months of their pregnancy. Our clinic offers different treatment options for managing miscarriage. The first involves a single medication (Misoprostol) and the second, two separate medications (Misoprostol and Mifepristone). At present there is no evidence to show that one works better than the other. Currently, the treatment you are given depends on the women’s choice and which one the treating doctor feels will be best for the patient. Currently, it is not clear if one treatment is better than the other . We hope that this study will if adding mifepristone to the treatment improves its effectiveness so that we can better manage miscarriage.

The aim of this study is to estimate the treatment effect of Everolimus in patients with pancreatic neuroendocrine tumours (PNET). Who is it for? You may be eligible to join this study if you are aged over 18 years and have newly diagnosed locally advanced or metastatic confirmed pancreatic neuroendocrine tumour (NET) of intermediate grade. Trial details All participants will receive treatment with Everolimus. This is a drug that can block activity of a protein called mTOR, and can slow the growth of different tumours including pancreatic NETs in the laboratory. Large studies in patients with pancreatic NET have shown that Everolimus treatment decreased the rate of tumour growth and increased patient survival. Two tablets of 5 mg Everolimus will be given daily for 6 months. Participants will be assessed regularly throughout the treatment period, and every 3 months after treatment has stopped in order to determine treatment effect. CT and PET scans will be used to measure tumour response and questionnaires will also be supplied to patients to assess symptomatic response to treatment.