ANZCTR search results

This study aims to explore the effects of a 4-week dietary fibre powder developed by ECU, known as urgut, (Provisional Patent 2023902137) as a dietary fibre powder in well-trained endurance athletes and community members with gastrointestinal (GI) disturbance. Outcomes of interest will be gut symptoms, gut transit time, gut microbiota and biomarkers of gut health in both stool and blood, as well as self-reported mental health, and quality of life.

Maintaining a normal temperature after birth is a major challenge for newborn survival and morbidity. Preterm infants less than or equal to 34 weeks’ gestation and less than or equal to 1500g weight are especially vulnerable to cold stress/hypothermia. Recommended interventions to prevent thermal loss at birth in preterm infants include moderation of environmental temperature, infant warmers, polythene bags/wraps, preheated mattresses, and heated and humidified gases. This randomised controlled trial compares two modalities (servocontrolled patient temperature management system vs. current standard) of thermoregulation during the transport of preterm and low birth weight babies soon after birth. We hypothesise that the servocontrol patient temperature management system will be more effective at maintaining babies temperature within normal range of 36.5-37.5 degrees Celsius. We aim to compare these two modalities to see which one is more effective at maintaining babies temperature during transport as a primary outcome and see whether it affects morbidity and mortality of preterm/low birthweight babies as a secondary outcome.

Patellofemoral pain (PFP) is the most common cause of knee pain in young adults (18-40 years), affecting 1 in 4 people and increasing the risk of knee osteoarthritis. This study will evaluate the feasibility of delivering an online education, exercise and anti-inflammatory food program for people with PFP delivered over 12 weeks.

We are undertaking a randomised controlled trial to test if it is feasible to conduct a full scale study of the safety and effectiveness of peer worker (people with lived experience of living and working in the farming community) delivered behavioural activation (a brief evidence based psychological treatment for depression) for people with moderate to severe depression. We want to find out if it is possible to recruit and train peer workers, if they can sucessfully deliver the intervention and if people from farming communities will agree to participate in a clinical trial.

Urinary tract infections (UTIs) are the most common postoperative complication following Botox injection in the bladder. The risk of UTI is approximately 24%. This study will see if taking a tablet of hiprex twice a day for six weeks could decrease the risk of urinary tract infection after Botox treatment. Hiprex is a medication that reduces the incidence of urinary tract infections in women with repeated urinary tract infections. We are comparing this to our current practice, where no further preventative medications are given other than the standard antibiotics during the procedure that everyone receives.

This study will investigate the proportion of adults patients who undergo liver transplantation who receive an ultra massive transfusion. Ultra-Massive Transfusion is a relatively new term that has generally been accepted to describe the transfusion of >20 units of packed red blood cells in 24 hours. There is a paucity of literature on ultra massive transfusion, which has almost exclusively been studied in the context of trauma surgery, where it is associated poorer postoperative outcomes and increased mortality. This retrospective single centre study will use electronic medical records from the Austin Health database from 1st Jan 2019 to to 1st January 2023. We will evaluate the outcomes and complications in patients undergoing liver transplant surgery who receive ultra-massive transfusion. These results may be used to aid prognostication of post-operative liver transplant patients, as well as identify, and therefore modify, factors that may predispose patients to poorer post-operative outcomes, ultimately aiming to reduce overall morbidity and mortality in this patient cohort.

Psoriasis is a chronic inflammatory skin disease that entails a significant risk of cardiovascular disease. Mitigating this risk through patient led primary and secondary prevention must be a treatment priority. This study aims to improve psoriasis patient activation (i.e. knowledge, skills and confidence), with respect to cardiometabolic health through the use of a text message intervention program, aimed at CVD prevention. We hypothesize that a structured text-messaging intervention of education- and lifestyle- targeted text messages, will improve psoriasis patient activation (knowledge, skills and confidence) regarding their health, preventative cardiovascular disease self-management and clinical outcomes compared to usual care.

The BUBs Quit individual randomised controlled trial aims to determine the effectiveness of the BQ smoking cessation intervention compared to standard care for pregnant women who smoke with regards to primary and secondary maternal and child health outcomes including smoking cessation at 3 months postpartum. The BQ study will comprise three concurrent phases: impact (phase 1), economic (phase 2) and implementation evaluations (phase 3).

To evaluate the accuracy and reliability of transabdominal and trans-perineal ultrasound in assessing the rectum, using colonoscopy or flexible sigmoidoscopy as the reference standard, and to explore the impact of subcutaneous adipose tissue(SAT) and bladder fullness on image quality and accuracy.

The purpose of this study is to determine the effect of an online mindfulness program (Carer_MindOnLine) among caregivers of people living with cancer. Who is it for? 200 adults who are experiencing higher burden while caring for people living with cancer will be invited to participate via social media platforms and cancer registries. Study details People will be allocated to one of two groups by random chance: the intervention group with immediate access to Carer_MindOnLine, or a usual care group who will receive the intervention after the follow up period. Carer_MindOnLine is a 9-week program where a new theme is introduced each week with a new meditation practice. People will be encouraged to practice mindfulness every day. At the end of the 9 weeks, participants will be asked to complete a series of surveys. It is hoped that this research will help determine whether mindfulness will be an effective method of assisting people in managing fear of cancer recurrence, anxiety, and depression.