ANZCTR search results

These search results are from the Australian New Zealand Clinical Trials Registry (ANZCTR).

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31380 results sorted by trial registration date.
  • Laser Intervention in Early Age-Related Macular Degeneration (LEAD) Study

  • The age-related changes of the meibomian glands in healthy participants

  • The comparison of the disposable Negative Pressure Wound Therapy Device (NPWT) to current standard dressings on medium sized Split Skin Grafts (SSG)

    Negative Pressure Wound therapy (NPWT) has been used in surgery for over 15 years for a whole range of wounds with good outcomes and many advantages to promote wound healing. Recent technological advancements have led to the production of a single use NPWT device designed for small to medium size wounds with low-moderate levels of exudates. Early uses of the dressing in literature have shown through individual case studies the potential use of Pico dressing for skin grafts leading to an earlier discharge date. However, there have been no broader studies of the use of Pico dressing in this specific treatment group. The Pico dressing is a type of single use negative pressure wound therapy produced by company Smith and Nephew. The study has been designed as a randomised control prospective trial. The main hypothesis to be tested is that the use of a single use negative pressure wound therapy with early discharge from hospital will have equal efficacy in wound healing to the current protocol of wound therapy.

  • Treatment effectiveness, compliance and cardiovascular outcomes with a new supine avoidance therapy for supine-predominant snoring.

    This is a research study of a new treatment device designed to discourage snorers from sleeping on their back, when snoring is mainly a problem when asleep on the back. The hypotheses of this project are that by avoiding sleeping on their back, snorers would have (1) reduced frequency and intensity of snoring episodes, (2) reduced overnight cardiovascular system disturbances, and (3) lower daytime blood pressure.

  • Effect of sterile versus non-sterile clean boxed gloves on surgical site infection during minor skin excisions in general practice: A prospective randomised control trial

    This project aims to determine whether the use of non-sterile clean boxed gloves in comparison to the existing guidelines of using sterile gloves in minor skin excisions has an effect on surgical site infection (SSI). Hypothesis: The use of non-sterile clean boxed gloves in minor skin excisions in general practice will not have an effect in increasing surgical site infections (SSI) compared to use of sterile gloves.

  • Dietary fat, airway inflammation and bronchodilator response in asthma - Study 2

    This study will investigate the mechanisms by which nutrient surplus heightens inflammatory responses and interferes with pharmacological management of asthma. Our previous work demonstrates that in asthma, consumption of a high energy mixed meal activates innate immune responses in the airways, with increased TLR4 expression and airway neutrophilia. The specific nutrient responsible for this effect is uncertain; therefore, we will assess the independent effects of saturated fat, omega-6 fat and carbohydrate. We have also observed that a high energy mixed meal leads to impaired bronchodilator responses; therefore, the effect of each of these nutrients on bronchodilator response will also be investigated. Understanding this process is vital, and highly relevant to asthma management, as effective bronchodilator response is essential for achieving good asthma control and providing bronchodilation during acute exacerbations of asthma.

  • A pilot study to evaluate an intensive upper limb rehabilitation program after stroke

    This project aims to develop and test the feasibility of a client­centred intervention for improving dexterity for people with stroke. Upper limb hemiplegia is common after stroke, and such people typically achieve lower levels of functional recovery. Many individuals suffering from hemiplegia after stroke exhibit some shoulder and elbow movement but little or no hand function, preventing them from participating in Constraint­ Induced Movement Therapy (CIMT). Using newer technologies such as a mechanical orthoses offers promise for stroke survivors with hemiplegia. However, no direct evidence exists for optimum wearing regimes, training protocols and timing of therapy. This study will therefore make a significant contribution to healthcare decision making. Participants in the 'treatment' group will be recruited from the Prince of wales in­patient hospital service and will receive an 8­-week intervention which will include intensive one­-on­-one movement training sessions, behavioural strategies to increase patient motivation, and a task ­specific home exercise program using a hand splint. Participants in the 'control group' will be recruited from the same centre and will receive usual rehabilitation. Outcomes will be assessed at baseline, post­ intervention, and at 3 months following the conclusion of intervention and will include assessment of range of movement, dexterity, functional task performance, and quality of life.

  • Does outpatient physical rehabilitation improve or maintain functional independence for people with Friedreich ataxia?

    Friedreich Ataxia is a degenerative disease impacting on the ability to mobilise and reducing independence in daily activities. This study aims to determine if outpatient rehabilitation improves or maintains functional ability and quality of life, as compared to a wait-list control. People attending a specialist multidisciplinary Friedreich ataxia clinic and who would benefit from rehabilitation, will be invited by the clinic to participate in this study. Consent will be gained at the Kingston Centre Participants appropriate for outpatient rehabilitation will be randomised into an intervention group or a control group, using a computer program. Intervention will be ‘accelerated’ standard-care, rehabilitation including physiotherapy, aquatic physiotherapy and exercises, and the wait-list period of the program will generate the control group. The duration of rehabilitation will be 6 weeks, and rehabilitation will be provided three times per week. A home exercise program will provided for participants in both groups to complete for six weeks following the rehabilitation program. Outcome measures will examine quality of life, disease progression, performance of daily life activities, mobility and spasticity. These measures will be taken at baseline, pre and post-rehabilitation, and six weeks following rehabilitation.

  • Effect of application of Transcutaneous Electrical Nerve Stimulation (TENS) on acupunture points (Acu-TENS) compared to Sham-TENS on breathlessness and exercise capacity in people with chronic obstructive pulmonary disease (COPD)

    Participants with COPD usually complain of dyspnoea during exercise which limits their exercise tolerance. Previous studies have shown that one session of Acu-TENS could alleviate breathlessness in participants with COPD (Lau and Jones, 2008; Ngai et al., 2011). The aim of the study is to evaluate the effect of Acu-TENS compared with Sham-TENS on exercise capacity and breathlessness in people with COPD. People with COPD who meet the inclusion and exclusion criteria will be recruited. After informed consent, each participant will attend for 4 visits. During the first visit, participants will be asked to perform two incremental shuttle walk test (ISWT) for determining the intensity level for the endurance shuttle walk test (ESWT). On the second visit, participants will be asked to perform two ESWTs to ensure accurate measure of endurance exercise capacity. On the third and fourth visit, participants will be randomly assigned to receive either Acu-TENS or Sham-TENS. Randomization sequence will be generated by a randomisation software by an investigator who is not involved in the data collection, and will be concealed in an opaque envelope. Both assessor and the patient will be blinded to the intervention. On visit 3 and 4, participants will perform one ESWT, followed by 45-minute of either Acu-TENS/ Sham-TENS which will be continued during the second ESWT. The change in endurance shuttle walk test time on visit 3 and 4 will be the primary outcome measure. Secondary outcome measures will be level of dyspnoea at isotime and distance walked in endurance shuttle walk test. The findings of the study will elucidate whether Acu-TENS will improve endurance exercise capacity and reduce breathlessness, thus, enabling people with COPD to improve functional capacity.

  • Effect of Sulforaphane on the Vascular Status and Oxidative status of Type 2 Diabetes

    The prevalence of Type 2 diabetes and its complications is increasing globally. The condition is associated with lifestyle factors which impact biochemically at many levels. Markers of oxidative stress are typically elevated in the diabetic condition but attempts to regulate oxidative stress with antioxidant vitamins have been generally unsuccessful. The plant-derived capsules to be used in this trial yield a phytochemical, sulforaphane which has been shown to activate pathways leading to elevation of the cell's endogenous antioxidant enzymes and other cytoprotective compounds such as glutathione. This trial is aimed at testing the efficacy of such capsules in modifying the disease parameters associated with Type 2 diabetes.

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