ANZCTR search results

The aim of this study is to investigate the efficacy of methylphenidate combined with individualised Attention Process Training (APT-3) in enhancing performance on neuropsychological measures of speed of thinking, complex attentional functions, and everyday attentional behaviour in a seven week randomised, placebo-controlled drug trial, with functional follow-up at 6 months. A secondary aim is to identify which factors, including injury severity and baseline attentional performance, will be associated with response to Attention Process Training and methylphenidate interventions.

For a successful colonoscopy, good views of the bowel lining are essential. Ideally, a bowel cleansing preparation should be effective at cleaning out the bowel but should also be well tolerated with minimal abdominal discomfort, nausea or other adverse symptoms. Historically, oral intake on the day prior to colonoscopy has been limited to clear fluids alone - without food. Rather than a restriction to clear fluids, a low-residue diet may also result in good quality bowel preparation. This research project is aiming to determine whether there is any difference in the bowel cleansing quality or how well it is tolerated (such as the degree of hunger, nausea, interference with daily activities) between a standard dietary restriction to clear fluids and a low-residue diet (one that contains few indigestible components) on the day prior to colonoscopy.

The aim of this study is to determine the optimal treatment for uncomplicated elbow fractures (undisplaced supracondylar humeral fractures) in children by comparing three treatment methods. A supracondylar humeral fracture is a fracture or break to the bone immediately above the elbow. Children identified with an undisplaced supracondylar fracture will be randomly allocated to one of three treatment groups which will involve different methods of external immobilisation. Pain during application of these various methods and functional outcome will be measured.

This study aims to compare labelled white cell scintigraphy (99mTc-HMPAO or 111-In labelled leukocytes) +/- 99mTc-HDP bone scintigraphy to FDG PET-CT in suspected osteomyelitis of the extremities to evaluate the feasibility of FDG PET-CT for infection imaging and to gain preliminary data on the agreement between FDG PET-CT and labelled white cell imaging/bone scan in infection imaging of the peripheries.

We hypothesise that the structure of the primary visual cortex in severely visually impaired participants will differ from that in participants with normal vision. Our aim is to develop a method of identifying the primary visual cortex during exposure of the occipital lobe of the brain during neurosurgery.

The aim of this study is to determine whether a self-management telephone based intervention will promote healing rates, physical activity levels, functional ability and self-efficacy for exercise for adults experiencing venous leg ulceration

The aim of the study is to compare the effectiveness of school dental therapist treatment of early childhood caries against the standard care within Dental Health Services of dentist provided treatment of early childhood caries among children 4 years of age or younger.

This study will evaluate the safety and efficacy of induction chemotherapy followed by maintenance with one of the two different drugs in elderly patients with metastatic non-small cell lung cancer. Who is it for? you may be eligible to join this study if you are male or female above 70 years and you have been diagnosed with metastatic non-small cell lung cancer. Trial details All participants will undergo upto 4 x 3 weeks cycles of induction chemotherapy with the drugs vinorelbine (taken as an oral tablet) and carboplatin administered into the vein (intravenously). Participants whose disease has not progressed will then be randomly (by chance) allocated to one of two groups. One group will take a vinorelbine capsule on day 1 and 8 of 3 week cycle. Participants in the other group will take one Erlotinib tablet every day. Participants in both groups will take the treatment till progression of disease, unacceptable side effects or if patient chooses not to continue the treatment. Participants will be assessed every 3-6 weeks until disease progression, death or unacceptable toxicities in order to determine quality of life and response to treatment.

Bladder dysfunction in people with Multiple Sclerosis is very common, very distressing and can affect the individual’s quality of life in many ways. Although it is strongly recommended that routine, targeted continence assessment be undertaken, this is poorly done by health professionals and inadequately discussed by patients. By appropriate screening and targeted continence treatment, initiated by a Continence Nurse, it is hoped that symptoms and quality of life will improve. This will be undertaken by comparing two groups of patients with identifiable continence problems, using a simple one page, double sided continence-screening tool, administered by the Continence Nurse. Participants in Group 1 will be offered assessment and management in line with standard continence practice by the Continence Nurse. Follow up will occur at 1, 3(by phone), 6 and 12 months. Participants in Group 2 will be offered standard care by the patient’s Health Care Team and tailored information endorsed by the Continence Foundation of Australia. The patients in Group 2 will subsequently be reviewed by the Continence Nurse following 6 months, and offered treatment as per the patients in Group 1, if symptoms persist.

Time spent in screen-based entertainment has been shown to be associated with adverse health and cognitive outcomes even in young children. Recent evidence suggests that a large proportion of young children exceed recommendations for screen-based entertainment. This project therefore aims to examine the feasibility, acceptability and potential efficacy of a program to reduce screen-based entertainment in young children. The intervention will be delivered to parents in intact groups over a 10-week period. Both the intervention and control groups will participate in the program and therefore we hypothesise that all participants will see improvements in the targeted outcomes. These include but are not limited to decreased screen-based entertainment, easier application of rules to support healthy behaviours and increased parental self-efficacy. Children may also display increases in physical activity and decreased sitting time. Participants’ results concerning their height and weight and time in screen-based entertainment will be forwarded to parents upon completion of analysis.