ANZCTR search results

This study aims to assess whether the side of the body that a central venous line is inserted affects the risk of developing a bloodstream infection in cancer patients. Who is it for? You may be eligible to join this study if you are a cancer patient aged 15 years or above, who needs to have a central venous access device (CVAD) inserted. Trial details Participants in this trial will be randomly (by chance) allocated to one of two groups. Participants in one group will have the CVAD inserted into their dominant arm (i.e. right arm in right-handed people and left arm in left-handed people). Participants in the other group will have the CVAD inserted into their non-dominant arm. There will be no other change to treatment provided. Participants will be monitored to determine the incidence of catheter-associated bloodstream infection (CA-BSI) and catheter-related bloodstream infection (CR-BSI). This will enable us to find out whether the increased movement of the dominant arm might increase the risk of infection.

A study to test the efficacy and safety of investigational therapy MK-8931 in the treatment of mild to moderate Alzheimer's Disease

The purpose of this study is to investigate whether nasal irrigation with a topical corticosteroid (mometasone) additive, is more beneficial in controlling the symptoms of chronic rhinosinusitis (CRS) post-operatively, than the treatments currently used. Irrigation with with a solution that contains mometasone may provide better control of CRS symptoms, compared to the simple intranasal steroid sprays that are currently used in conjunction with salt water irrigation. Patients undergoing endoscopic sinus surgery as part of the management of their CRS are eligible to participate. Patients who choose to participate in the study will be randomly allocated to one of two treatment groups. This is a double-blinded trial, so neither the patient, nor the patient's treating surgeon will know which treatment group the patient has been allocated to.

This evaluation trial will evaluate a brief parent Lifestyle Triple P Seminar program for parents of overweight children aged 3 – 10 years of age in a randomised trial comparing the parenting intervention against care as usual. The CONSORT guidelines for randomised controlled trials will be utilised. The study is a 2 (Triple P vs case as usual) x 4 (time: pre-test, post-test, 6-month follow up, and 12-month follow up) design. The study will experimentally test the relative impact of Triple P against care as usual in improving both general and lifestyle-specific child and parenting outcomes. The trial is recruiting all over Brisbane and Ipswich suburbs.

This is a study aiming to evaluate whether metformin, an antidiabetic medication, can be used safety and effectively in patients with type 2 diabetes who are receiving peritoneal dialysis for their end stage kidney disease. The study runs over 4 weeks of active treatment, 250mg of metformin daily orally. We hypothesise that metformin can be safely used in patients with type 2 diabetes with end stage renal failure if dosed based on predicted drug clearance.

The study aims to analyse the effect of cooling, combined pre-cooling and cooling during exercise, in cycling with a passive cooling vest on core body temperature, heart rate, balance, physical capacity and fatigue of individuals with MS and general people.

Air is currently used as the insufflation agent during colonoscopy to allow for visualisation & detection of colorectal lesions. Recently, there has been a trend towards introducing carbon dioxide as an alternative agent as this reportedly reduces post-procedural discomfort. There have been several trials internationally that have revealed this trend, but none so far in Australia. Our aim is to randomise adult patients with intact colons (those who have not undergone any bowel resection) to either air and carbon dioxide with the aim of assessing and comparing their post-procedural discomfort using a visual analog scale from 0 to 10. Other information such as the time to completion of the procedure and time to reach the end of the colon (that is the caecum) will be obtained. We propose that the use of carbon dioxide as the insufflation agent during colonoscopy is better in terms of improvement of post-procedural discomfort than air.

Intrauterine growth restriction is the term used to describe a condition where an unborn baby does not reach its optimum size. In the short and long term, intrauterine growth restricted babies have a higher risk of serious disease and even death. It is well established that very low levels of oxygen in the baby's blood can harm the baby's health through a state known as oxidative stress. Currently, there is no established treatment available to treat intrauterine growth restriction or its complications. In experimental animal studies however, the naturally occuring hormone, melatonin, has been shown to significantly reduce oxidative stress and improve health of the unborn babies that have suffered from intrauterine growth restriction. This study aims to find out if the use melatonin twice per day throughout pregnancies affected by intrauterine growth restriction will lower the level of oxidative stress experienced by the unborn baby. If this is the case melatonin may help protect the unborn baby from damage caused by oxidative stress, this will be studied in a separate future study.

Although the association of nutritional composition of foods with health parameters is well established, the physical structure can influence the digestion, absorption and consequently may affect caridovascular health indices namely, circulating lipid levels, inflammatory mediators and satiety hormones. Interactions between the nutrients due to food processing can change, influencing the accessibility of the digestive enzymes for hydrolysis. In this context, although type of dietary fat consumed has been shown to modulate blood cholesterol levels, the matrix of the food may influence its cholesterol raising/lowering potential. Accordingly, the rate of absorption of fat from a meal containing whole almonds has been shown to be much slower compared to almond oil. The aim of this project is to examine the effects of matrix in which almond lipids are complexed on postprandial lipid levels, inflammation markers, and satiety hormones. This will be achieved by determining the effects of feeding four different almond preparations, i.e. lipids trapped within the cell walls (raw almonds), oleosin-stabilized lipid emulsion (almond extract or milk), casein-stabilized lipid emulsion (almond oil emulsion) and lipids as free oil (almond oil). We hypothesise that the rate of absorption of fat from almonds, almond oil and emulsified almond oil will be different and in turn may influence cardiovascular disease risk factors.

Background & Aim There is a controversy on whether listening to music prior or during colonoscopy reduces anxiety, pain and improves satisfaction and compliance with the procedure. In particular, music has been found to reduce anxiety around colonoscopy in a number of studies. However, these studies only used first time colonoscopy patients, self-selected music for 15 minutes prior to the procedure and were focusing on pre-procedural anxiety. Further, only one previous study used theory to design a specific music track. However, the music used there was Turkish classical music and thus studies with Western populations and music known to them are needed to avoid possible cultural bias. Future studies should explore theory based interventions since the majority of current studies (i.e. using self-selected music) did not explain why this method was chosen, did not record the frequency of each genre of music selected or did not consider it in their analysis and controversies in findings may be due to particular designs rather than theory versus self-selected music. In addition, one previous study found that providing self-selected music via headphones during the procedure significantly reduced the self-reported pain. However, other studies in which background music or self-selected music via headphones was used during the procedure showed no significant differences in pain between the conditions. Further, several previous studies have shown that music (both self-selected and investigator selected) may reduce the sedation required during colonoscopy. Music has also been shown to increase the patient satisfaction of colonoscopy. Thus, this study aimed to establish whether specifically designed music significantly affects anxiety, pain and experience associated with colonoscopy. Methods This semi-randomized controlled study selected music, using theory, for the purpose of relaxation. Thirty-four day patients undergoing a colonoscopy were provided with either muted headphones (n=17) or headphones playing the investigator-selected music (n=17) for 10 minutes prior to and during colonoscopy. Anxiety, pain, sedation dose and overall experience were measured using quantitative measures and scales. Results Participants’ state anxiety decreased over time (p<0.001). However, music did not significantly reduce anxiety (p=0.441), pain scores (p=0.313) or midazolam (p=0.327) or fentanyl doses (p=0.295). Despite these findings, 100% of the music group indicated that they would want music if they were to repeat the procedure, as compared to only 50% of those in the non-music group wanting to wear muted headphones. The majority would not want to pick their own music. Conclusions Although no significant effects of music on pain, anxiety and sedation were found, a clear preference for music was expressed, therefore warranting further research on this subject. Larger studies are needed and data on the most appropriate music for colonoscopy should also be obtained as all music may not be equally efficacious.