ANZCTR search results

We wish to investigate whether patients with unilateral sciatica whom take chronic opioid therapy, patients with unilateral sciatica whom do not take opioid therapy and pain-free participants have different sensitivities to hot and cold temperature sensations.

The purpose of the study is to determine the clinical outcomes and effectiveness of two randomly allocated treatments used to manage acute anterior shoulder dislocations: six weeks of external rotation bracing versus early arthroscopic shoulder stabilisation intervention. It is hypothesised that the arthroscopic shoulder stabilisation surgery may lead to better patient outcomes compared with the external rotation bracing on the basis that evidence for external rotation bracing is still emerging and (although promising) has not yet been established with as much rigor as arthroscopic shoulder stabilisation surgery. However, in the absence of substantial differences in patient outcomes, external rotation bracing may be demonstrated to be more cost-effective than surgery. Outcomes from this study will inform clinical decision making about management for young people with shoulder dislocation. This study will not only impact clinical practice for this high demand patient group in Queensland, but nationally and internationally due to widespread uncertainty to the effectiveness (and cost-effectiveness) of the (cheaper and more conservative) external rotation bracing in comparison to arthroscopic shoulder stabilisation surgery amongst young patients (16-30 years) who have dislocated their shoulder for the first time.

We aim to conduct a mixed methods evaluation of the impact on patients of a 6 week mindfulness and Essence based lifestyle program with community living adults with disability congruent with stage 2 (Hoehn and Yahr staging) Parkinson’s Disease. Quantitative study aims. To determine whether: 1. Participation in a 6 week mindfulness and Essence based lifestyle program improves PD disease related function in patients with disability consistent with stage 2 Parkinson’s disease? 2. In these patients, does the Essence program influence patient a) health beliefs; b) mental and emotional health; c) health locus of control? Qualitative study aims. To better understand: 3. What are the experiences of patients with PD attending the mindfulness based intervention? 4. Beliefs about disease management before and after the program? 5. How attitudes towards their health efficacy evolve over the course of the program? 6. What aspects of the program were most valuable and meaningful? 7. How people engaged with the program?

An observational post-market, open label, multicenter study designed to assess the clinical utility of the WEB Aneurysm Embolization System. The proposed clinical study is a non-randomized, multi-center, prospective confirmatory study to assess the safety and efficacy of the WEB Aneurysm Embolization System.

This project investigates the feasibility of a larger Randomised Controlled Trial into a web-based self-help program for suicidal thoughts.

This study will investigate whether individuals who are receiving inpatient rehabilitation following an acquired brain injury (ABI) are able to participate safely in a meditation based stress reduction program. In addition we will try to determine whether participants’ level of “mindfulness”, cognitive performance, level of anxiety, levels of vitality and overall perceived quality of life improves in response to their participation in the program compared to a control group.

This project is part of a research program funded by the NHMRC (No. 630560) to develop and evaluate Internet based transdiagnostic education and treatment programs for people with anxiety and depression. This project examines the relative efficacy of a disorder-specific internet-delivered treatment for generalised anxiety disorder vs. trans-diagnostic internet-delivered treatment for both anxiety and depression. Both interventions will be tested in guided and self-guided formats. We expect that the guided interventions will result in superior outcomes to the unguided interventions. We do not expect differences between the two guided interventions at post-treatment, but expect that the trans-diagnostic treatment will result in superior outcomes at follow-ups.

Insertion of an artificial airway for respiratory failure, either endotracheal, nasotracheal or tracheostomy, inhibits normal mucociliary clearance, thus increasing the risk of secretion retention and pneumonia. Suctioning of the artifical airway is one of the most common procedures in the intensive care unit and high dependency wards: the aim is to remove respiratory tract secretions, thus maintaining airway patency, and prevent complications of secretion retention. Normal saline instillation is defined as delivery of 2 to 10 cc of normal saline solution (0.9%) into an artificial airway prior to suctioning. This technique is utilised by many health practitioners and is believed to increase sputum yield by diluting and loosening secretions, stimulating a cough and lubricating the suction catheter. However, there are conflicting views about the safety and efficacy of this procedure. To date studies have investigated saline instillation as a stand alone technique and not as part of a respiratory physiotherapy regimen. The aim of this trial is to examine the effects of normal saline instillation on sputum clearance, haemodynamic parameters, oxygenation and respiratory mechanics during physiotherapy in patients with an artificial airway. Design Prospective, single blinded, randomised, cross-over design where patients act as their own controls. Patients will be randomised using a computer generated sequence. Those allocated to group A will have saline instillation prior to suction during physiotherapy on day one, day two no saline will be used. The reverse will happen for those patients allocated to group B. Investigator collecting outcome measures will be blinded to group allocation. Participants Adults >18 years, expected to be mechanically ventilated for >48 hours. Outcome measures The primary outcome measure is sputum weight. Sputum will be collected during physiotherapy.Secondary outcome measures include airway resistance, oxygenation, blood pressure and heart rate which will be calculated at various times pre and post procedure. Significance This study would add to the body of knowledge regarding the efficacy and safety of saline instillation during physiotherapy in the intensive care unit.

This project is part of a research program funded by the NHMRC (No. 630560) to develop and evaluate Internet based transdiagnostic education and treatment programs for people with anxiety and depression. This project examines the relative efficacy of a disorder-specific internet-delivered treatment for panic disorder vs. trans-diagnostic internet-delivered treatment for both anxiety and depression. Both interventions will be tested in guided and self-guided formats. We expect that the guided interventions will result in superior outcomes to the unguided interventions. We do not expect differences between the two guided interventions at post-treatment, but expect that the trans-diagnostic treatment will result in superior outcomes at follow-ups.

This project is part of a research program funded by the NHMRC (No. 630560) to develop and evaluate Internet based transdiagnostic education and treatment programs for people with anxiety and depression. This project examines the relative efficacy of a disorder-specific internet-delivered treatment for social phobia vs. trans-diagnostic internet-delivered treatment for both anxiety and depression. Both interventions will be tested in guided and self-guided formats. We expect that the guided interventions will result in superior outcomes to the unguided interventions. We do not expect differences between the two guided interventions at post-treatment, but expect that the trans-diagnostic treatment will result in superior outcomes at follow-ups.