ANZCTR search results

This study is aimed at improved PET scanning diagnosis of liver secondaries from colon cancer. There will be no recruitment of patients from outside of the Royal Brisbane and Women's Hospital.

The aim of this study is to determine the RS content of finely milled new varieties of barley (in muffin bars) using ileostomy participants.

The initial pilot study for this trial was registered with ANZCTR (ACTRN12610000532000) and completed in July 2010. The purpose of this study is to ascertain whether oral garlic tablets reduce vaginal colonisation of Candida (the yeast that causes thrush) when taken in the second half of the menstrual cycle, in women of childbearing age. Women will be asked to take three garlic tablets (or placebo) for two weeks, as well as send daily vaginal swabs to the laboratory for analysis, and complete a daily diary. This will give information not yet known about colonisation patterns of Candida in the second half of the menstrual cycle, as well as whether or not oral garlic tablets may be helpful in reducing recurrences of episodes of vaginal thrush.

A trial to see if the use of a cyanoacrylate ("Superglue") sealant applied to the skin prior to the surgical incsion can reduce the incidence of post operative wound infections.

This double-blind, randomised, placebo controlled trial will examine the safety and efficacy of intranasal oxytocin for the treatment of cannabis and alcohol dependence. It is hypothesised that participants randomised to the oxytocin condition, compared to participants randomised to the placebo condition will have a higher rate of treatment completion, experience reduced number, severity, and duration of cannabis and alcohol withdrawal symptoms and will report fewer days of cannabis and alcohol use at one month follow-up.

The hypothesis is that in healthy humans dietary omega-3 fatty acids and aspirin enhance the formation of the potent antiinflammatory metabolites resolvins and protectins. Specifically, we aim to determine blood resolvin and protectin levels in a randomised controlled trial of aspirin or placebo in healthy men and women taking omega-3 fatty acids.

The primary purpose of this study is to determine the effectiveness of temozolomide therapy in the management of aggressive pituitary tumours. Case reports have suggested that temozolomide may be efficacious in the treatment of pituitary tumours, and this needs to be tested now in a prospective controlled trial with larger patient numbers. In addition, this trial will determine whether there are molecular markers present in tumour tissue that may help predict which patients will benefit most from this therapy.

Objectives: To compare the efficacy of two nasogastric rehydration regimens in children with acute viral gastroenteritis. Patients and methods: Children aged 6-72 months with acute viral gastroenteritis and moderate dehydration were recruited from Emergency Departments (ED) at two metropolitan pediatric teaching hospitals. After a clinical assessment of the degree of dehydration, patients were randomized to receive either standard nasogastric rehydration (SNR) over 24 hours in the hospital ward, or rapid nasogastric rehydration (RNR) over 4 hours in the ED. Primary treatment failure was defined as weight loss of >2%, compared to the admission weight. Secondary treatment failure was defined as the need for (re-)admission to hospital, insertion of an intravenous line for rehydration or inability to tolerate nasogastric rehydration. Results: Of 9331 children with acute gastroenteritis screened, 228 children were recruited and randomized (RNR 119 [52.2%], SNR 109 [47.8%]). Baseline characteristics for both groups were similar. All patients made a full recovery without severe adverse events. Primary failure rate at 24 hrs was similar for RNR 12.6% (95% confidence interval [CI]; 6.6–18.6) and SNR 8.3% (95%CI; 3.1–13.5); p=0.12. Secondary treatment failure was more common in SNR patients 44% (95% CI; 34.6–53.4) vs RNR 31.1% (95%CI; 22.0–38.6); p=0.03. Discharge from the ED after RNR failed in 28 (23.5%) patients, and 9 (7.5%) were re-admitted within 24 hrs. Conclusion: Primary treatment failure and clinical outcomes were similar for RNR and SNR. While RNR generally reduced need for hospitalization, discharge home from the ED failed in about one quarter of patients.

The purpose of this study is to know if it is feasible to do a randomized controlled trial by allocating the freshest available red blood cells in critically patients, versus standard care.

DHA is an omega-3 fat found in fish and fish oils and is thought to effect an infant's developing immune system. While in the womb, the baby is supplied with DHA from the mothers circulation. This study will help determine whether increasing the amount of DHA in the diet of pregnant women reduces allergies in their children.