ANZCTR search results

Patients with complex lower limb trauma experience severe pain. Opioids and inflammation activate glia which may increase the severity of pain experienced. Minocycline acts via inhibiting Toll Like Receptor 4 and may reduce pain severity if given early. This and drugs with similar effects at TLR4 receptors appear to work well in animal models of severe pain. Minocycline may also reduce opioid tolerance and opioid side effects particularly respiratory depression.

The aim of this study is to evaluate the efficacy of an internet guided education program for OCD and a guided bibliotherapy education program for OCD compared to waitlist control. It is hypothesized that: 1. Participants in the Internet Group will obtain results at least equivalent to those obtained in the recent pilot study (ACTRN12610000687099), and superior to those in the Waitlist Group. 2. Participants in the Bibliotherapy Group will obtain improvements significantly greater than those in the Waitlist Group. 3. There will be no difference in outcome between the two active groups 4. Both active treatment groups will find the treatment acceptable.

Patient matched instruments use pre-operative MRI and radiographs to produced custom instruments for total knee replacement surgery. We aim to verify the accuracy of these blocks using standard intra-operative navigation with computer assisted surgery, and post-operatively with xray assessment.

The aim of this study is to investigate the feasibility of implementing low intensity interventions within a university health service. The objectives are to: 1. Increase the identification and early intervention of students who are experiencing high levels of distress. 2. Evaluate the effectiveness of low intensity intervention on student wellbeing (vs. screening and treatment information alone); 3. Evaluate uptake, retention, and perceived relevance and utility of LI-CBTs within a health service context.

Chronic diseases such as chronic obstructive pulmonary disease (COPD) are characterised by chronic, underlying organ dysfunction with intermittent acute worsening of the disease that often results in hospital admission. There is good evidence to suggest that regular monitoring of certain physiological and symptom related variables in the homes of patients with COPD may be beneficial. If deterioration can be detected early and appropriate interventions instituted, it may be possible to achieve improved patient outcomes and a reduction in the use of healthcare resources. The technology to remotely monitor relevant physiological variables in the home situation is now available and there is some evidence that these devices are robust and capable of being reliably used by patients with COPD. Randomised controlled studies in this field are needed to establish the efficacy of RPM and to better define the role of this new technology in managing these conditions. We designed a randomised controlled trial to determine whether remotely monitoring symptoms, medication usage and physiological variables over 12 months was feasible in patients with moderate-severe COPD and whether this intervention could improve quality of life or reduce healthcare use.

Early Childhood Caries (ECC) causes profound suffering, frequently requiring expensive treatment under a general anaesthetic. It is associated with other chronic childhood conditions such as otitis media and nutritional disorders, and is the strongest predictor of poor oral health in adulthood. Despite ECC being entirely preventable, marked ECC disparities exist between Indigenous and non-Indigenous children in Australia. If the burden of ECC and associated oral health inequalities experienced by Indigenous children are to be reduced, more needs to be done to ensure that appropriate preventive measures, together with support for maintaining optimal oral health, are provided to carers of such children in the early life stages. This will be an interventional study, with all participants receiving the intervention benefits. The intervention will be implemented from birth and continue for the first three years of a participating child’s life. It will involve four components; dental care provided to mother during pregnancy, application of topical fluoride to the teeth of children, anticipatory guidance and motivational interviewing. Developing a culturally-appropriate ECC intervention that aims to improve child oral health will provide much needed evidence for policy makers to address the challenge of improved oral health and related outcomes for Indigenous children.

This study looks at the safety and tolerability of the drug lenalidomide in combination with 5-azacitidine when used as maintenance therapy for patients with Acute Myeloid Leukaemia (AML) who are in complete remission. Who is it for? You can join this study if you are an Acute Myeloid Leukaemia (AML) patient who is in complete remission (CR), or complete remission with incomplete count recovery (CRi). Trial details Participants will be split into one of 7 cohorts (treatment groups) for this trial, with each cohort receiving varying doses of subcutaneous injections of Azacitidine on days 1-5, followed by oral tablets of Lenalidomide from days 5-25 of each treatment cycle. Participants will be assessed at regular intervals to determine their response to treatment. The aim of this study is to determine the safety and tolerability of these combination doses.

The majority of older people living in retirement villages are at risk of medication misadventure. In our recent survey of about 2,000 retirement village residents in Victoria, two-thirds had at least one medication-related risk factor, and hence were eligible to receive a pharmacist-conducted Home Medicines Review (HMR), a government-subsidised health service recommended annually for people who are at risk of medication misadventure. However, the uptake of HMR in this group has been very low (6%). The proposed project aims to develop, implement and evaluate a multi-component intervention (based on stakeholder recommendations) for increasing HMR uptake among RV residents. The study will involve 150 to 200 retirement village residents who will be randomly allocated to one of the two groups depending on the retirement village they live in; half will receive the intervention and the others will receive usual care. The intervention comprises educating residents regarding their medication risk and benefits of HMR, and notifying residents’ general practitioners of residents’ risk of medication misadventure using a risk assessment form/checklist. Participants will be followed up by phone and questionnaire at three and six months from baseline to assess if they have had received a HMR. This information will be further confirmed with participants’ health professionals.

Fentanyl is a strong analgesic (painkiller) with similar effects to morphine. Recently a fentanyl wafer has been developed that dissolves quickly when placed under the tongue. This has advantages of quick absorption, rapid onset of action and would be suitable for patients who cannot swallow tablets, or are phobic to needles. The present study compares the pharmacokinetics and bioavailability of the sublingual wafer fetanyl formulation with the currently registered IV forumulation.

The GLAMA and BLAST project aims to assess the effect of a Year 10 peer leadership program on self efficacy, school connectedness and physical activity during Year 7 transition into Secondary School.