ANZCTR search results

This study aims to evaluate the changes in lung function caused by the use of continuous positive airway pressure compared to standard therapy in patients who have been diagnosed with a worsening of their heart failure. Continuous positive airway pressure is a way of delivering pressure to the airway through a mask connected to a machine. It is used routinely in the treatment of heart failure to improve outcomes but how it works on the lungs is not well understood. By using a method of measuring lung function that can be done whilst on continuous positive airway pressure and that requires minimal active patient co-operation this trial hopes to provide insight into the mechanisms of this treatment.

The study aimed to help inform how best to deliver nutrition services to older adults identified at risk of malnutrition, through the provision of frequent, individual nutrition support by a dietitian from the Emergency Department, compared with the provision of the current service to community-dwelling older adults identified as at risk of malnutrition. This investigation aims to assess the impact of the service provided on the nutritional status and other outcomes including frail mechanical falls, hospital admission and quality of life.

The primary purpose of the study is to assess the safety and tolerability of one oral dose of a human rotavirus vaccine, RV3-BB, in three successive age groups starting with adult men aged 18-50 years, progressing to children aged 3-8 years and then infants 6-8 weeks. Assessing rotavirus immunity, via serologic markers and faecal extracts, is a secondary objective.

The purpose of this study is to confirm that gluten-containing foods causes abdominal symptoms and fatigue in people who do not have coeliac disease and to investigate if these individuals can tolerate a low-dose of gluten.

The study intends to assess the human and financial cost benefits of providing aged care workers with enhanced working conditions including proactive physiotherapy care of joints and muscles separate from and together with direct psychlogical support in building stress resilience and indirectly through developing 'top down' improvement in psychosocial safety culture and enhanced team leadership. It is anticipated that both physiotherapeutic and psychological interventions alone will reduce the human and financlal cost of work related physical and emotional stress. We further anticipate that physical and psychological support combined will act synergistically to reduce injury (physical and emotional). Such reductions are anticipated to be demonstrable via objective measures of cost saving as well as self report of enhanced well being.

The study aims to establish whether taurocholic acid, administered as a suppository, can stimulate secretion of the gut peptides GLP-1, PYY, and oxyntomodulin, and suppress subsequent appetite and food intake. This information could be useful in designing treatments for type 2 diabetes and obesity.

PVP is a new procedure that may one day be able to replace TURP as the main treatment for men with benign prostate enlargement. There has only ever been one randomized controlled trial of PVP with TURP and this was using the now outdated 80W model. Recent advice from the UK National Institute for Health and Clinical Excellence has stated that PVP should only be used in the context of randomized controlled trials. We intend to assess whether the procedure has long term benefits for patients and whether it is cost efective for health providers.

The purose of this study is to understand how well Oxycodone in combination with tocopheryl phosphate mix (TPM), is absorbed through the skin and into the bloodstream, with the use of a patch.

This study seeks to determine whether the Girls on the Go program is able to improve the self esteem of young girls and reduce their risk of developing disorders related to body image. It is hypothesised that the program will improve participants self esteem and reduce their risk of developing disorders related to body image.

The purpose of this study is to evaluate the effectiveness of probiotics in reducing the recurrancce of urinary tract infection (UTI) in people with spinal cord injury and other neurological disorders. It is hypothesised that probiotics reduce the incidence of UTI.