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This study looks at the effectiveness of different combinations of treatment with oral Temozolomide chemotherapy and radiotherapy, in people with brain cancer of the type non 1p/19q deleted anaplastic glioma. Who is it for? You can join this study if you have brain cancer that has been newly diagnosed (anaplastic oligodendroglioma, anaplastic oligoastrocytoma or anaplastic astrocytoma) and you are not missing chromosomes 1p/19q. Trial details Participants will be randomly divided into four groups which will receive treatment as follows: 1. radiotherapy only 2. radiotherapy and Temozolomide chemotherapy at the same time 3. radiotherapy and Temozolomide chemotherapy four weeks later 4. radiotherapy and Temozolomide chemotherapy at the same time and then Temozolamide chemotherapy again four weeks later. The study aims to assess whether 1. radiotherapy and Temozolomide chemotherapy at the same time improves overall survival rates when compared with radiotherapy alone 2. Temozolamide chemotherapy given after radiotherapy improves overall survival when compared to no Temozolamide after radiotherapy. Currently different institutions adopt different strategies of radiation and chemotherapy for treating anaplastic glioma, as the most effective treatment is not known. However some studies suggest that there is an increase in progression free survival when chemotherapy is given after radiotherapy. Many glioma patients deteriorate at the time of progression. Thus prolonging the time to progression may help to keep patients in good clinical condition for longer and improve their quality of life.

A between subjects randomized controlled trial is being used to assess the efficacy of oxytocin delivered alongside interaction coaching and massage to improve maternal behaviour towards the infant.

assessment of nail changes to patients undergoing chemotherapy with taxotere. Nail bed toxicity was assessed by physical examination, questionnaire completion and photographs. Study participation during chemotherapy treatment and up to 3 months post chemotherapy.

The purpose of this study is to evaluate the effectiveness of class-based physiotherapy and one-to-one physiotherapy , compared to a monitored home program after total knee replacement surgery. The study hypothesis is that one-to-one physiotherapy will be superior compared to class-based physiotherapy or a monitored home program.

The objective is to investigate whether diphencyprone (DPCP), a chemical which can cause contact allergy on the skin in about 95% of people, can stimulate the immune system to destroy these melanoma cells. DPCP is frequently used in dermatology as a treatment for autoimmune hair loss (alopecia areata) and warts, where it also stimulates an immune attack on the wart virus. As melanoma is a tumour which is known to be particularly susceptible to immune attack, it is hoped that DPCP treatment will be helpful to patients with otherwise untreatable secondary melanoma in their skin. There have so far been a handful of published case reports of patients in whom DPCP has been helpful for melanoma.

The study will examine the uptake into, and removal from the human body, of meloxicam. The update and removal of meloxicam from the Meloxicam Nanoformulation capsules and marketed capsules (called Mobic (R)) will be compared, when they are taken after a fast and after a high fat breakfast. There will be four treatments in the study. The Sponsor wants to know if the meloxicam in the Meloxicam Nanoformulation capsules is absorbed more quickly than the meloxicam in Mobic(R).

The primary aim is to establish sound scientific evidence of the effects of ground walking training in people with COPD. The secondary aim is to evaluate whether novel feedback strategies can improve long term adherance to exercise training for people with COPD in order to gain important health benefits and markedly reduce health resource use and costs.

Singing has been shown to be beneficial for chronic respiratory conditions. Singing is not merely a vocal expression; it involves a physical transformation. Singing requires well-controlled breathing and good posture. The lungs and abdominal muscles are fully engaged to produce sounds. Classically trained singers demonstrate more efficient respiratory capacity. Previous research also indicates that singing can improve quality of life, reduce anxiety, and enhance self-esteem. Let’s Sing Out! is an innovative research project to enhance the physical and mental health of young people with CF. Eight half-hour individual singing sessions include learning diaphragmatic breathing, and singing favorite songs in a supportive environment.

Some people with chronic whiplash have increased sensitivity to various stimuli such as pressure and cold. These people don’t respond as well to standard exercise based approaches to treatment. Dry-needling techniques have been shown to decrease the sensitivity in other conditions, but the effects for people with whiplash it not known. Dry needling is one of many techniques used by physiotherapists. It involves tapping a very fine needle into the tender muscle areas and it is similar to acupuncture. This study aims to find out whether or not dry-needling added to a standard exercise program will decrease pain and disability in people with chronic whiplash. We also need to know whether or not the effects are better than those of ‘sham’ dry-needling and exercise. It is hypothesised that dry needling will decrease pain and hypersensitivity associated with chronic whiplash and thus facilitate the effects of the exercise program.

The major goal of this research project is to implement and evaluate a structured state-of-the-art peer-led group program to improve daily management, social and emotional support, linkages to clinical care and ongoing support for people with Type 2 Diabetes Mellitus (T2DM). It seems likely that the benefits of such programs, compared to those delivered exclusively by health professionals, results from features of the social support offered and the connections established with local community resources and other supports. The evaluation proposal also includes a comprehensive health economic evaluation of the cost-effectiveness of the program as well as its future transferability to other settings and countries in the Asia Pacific Region and Southern Africa. The project could significantly influence the successful implementation of peer-led diabetes management programs across these countries and Australia. The aims of the trial are: 1. To implement and evaluate the impact of the Australasian Peers for Progress-Diabetes Program (PfP-DP) on diabetes self management, social and emotional support, linkage(s) to clinical care and ongoing support. 2. To evaluate the cost-effectiveness of PfP-DP and its potential long-term benefits and potential transferability to other settings and countries. 3. To identify salient enablers and barriers to future system-wide uptake in Australia and potential transferability to Malaysia and other middle income countries in Asia and Southern Africa. Hypothesis: Compared with those in the wait-list control condition, participants in the Australasian PfP-DP will demonstrate significantly greater improvements in HbA1c at 12 months following baseline measurement, and will show improvements in diabetes self-management, social and emotional support, linkages to clinical care and ongoing support.