ANZCTR search results

A cluster randomised controlled trial to test a range of care enhancement strategies to increase the proportion of Aboriginal and Torres Strait Islander clients attending mainstream general practice with an up-to-date Health Check. Care enhancement strategies include: Study Champions at the practice to drive positive change, information for patients about the benefits and availability of Health Checks; reminders for eligible patients who are due for a Health Check, continuing professional education for practice staff, and data-based feedback provided to practices about the rates of Health Checks in their practice. Building on existing processes implemented in the participating practices and within the local Primary Health Network, care enhancement strategies will be tailored to the individual practices and the Aboriginal and Torres Strait Islander Communities they serve. It is hypothesised that the Care Enhancement strategies will lead to an increase in the proportion of Aboriginal and Torres Strait Islander patients who have an up to date Health Check and receive best practice care.

This study aims to determine whether advanced MRI scanning techniques can provide more detailed information regarding high-grade brain tumours in patients who have brain cancer. Who is it for? You may be eligible for this study if you are aged 18 years or older, you have been diagnosed with a grade 4 glioma or astrocytoma (brain tumour) and you are able to undergo an MRI scan. Study details All participants who choose to enrol in this study will be asked to undergo a single MRI scan. This scan is anticipated to take 60 minutes/hours. You will need to have a tracing agents injected as part of this scan (as you would usually). There are no extra blood tests as part of this study but you will be invited to contribute a blood sample for biobanking It is hoped this research will determine whether advanced MRI scanning techniques can identify biomarkers specific to brain tumours, and provide further information about the location and type of brain tumour for cancer patients. If these techniques are successful, the information provided by the MRI scans could assist doctors to determine which treatment options would be most effective for patients with brain cancer.

This study aims to examine the feasibility of a mobile application to collect follow up health data about Hodgkin Lymphoma survivors. Who is it for? You may be eligible to participate in this study if you are a patient aged 18 years or over, and must have received treatment for histologically confirmed classical HL according to the WHO classification. Study details Participants will enter their Hodgkin treatment and lymphoma response information, then complete a quesitonnaire on their current medical health including cardiac, respiratory, fertility, endocrine health. It is hoped that the results of this trial will help improve the lives of HL survivors.

The question of this study is: Would access to e-bikes combined with behavioural support enable sedentary adults to improve their levels of physical activity? The study aims at exploring the effects of e-biking combined with behavioural support on levels of physical activity. The hypothesis is that the MI-CBT supported intervention results in attainment of physical activity guidelines among previously inactive participants.

This program of research aims to safely reduce antibiotic use by supporting the implementation of best-practice Antimicrobial stewardship guidelines in general practice. These resources will support GPs treating adults with acute respiratory infections (ARIs). A UOW research team and collaborators, led by Profs Andrew Bonney and Judy Mullan, has been successful in being awarded a Medical Research Futures Fund grant (ID: MRF2029531) to conduct this research. This study is called the Optimal Implementation of Antimicrobial Stewardship in General Practice (OPTIMAS-GP) study. This pilot study will inform a larger randomised control trial.

In this study, we are interested in looking at the acute effects of the anti-Parkinson drug, levodopa/carbidopa (Sinemet®) on the rate of stomach emptying, blood pressure and abdominal blood flow after a sugary drink, and the relationship between the rate of stomach emptying and the rise in levodopa levels. The primary hypotheses underlying the study are that (i) a therapeutic dose of levodopa (200mg) / carbidopa (50mg) will slow gastric emptying in patients with mild to moderate Parkinson’s disease and (ii) this slowing of gastric emptying will be associated with an attenuation in the fall in blood pressure, and the rise in superior mesenteric artery (SMA) blood flow, after oral glucose.

The transition from hospital back into the community can be a difficult time for patients to navigate due to the involvement of multiple health professionals, medication changes and complex health care plans. These factors place patients at risk of medication-related harm during the transition of care (ToC) period. This study will use a prospective pre-post interventional study of a locally appropriate pharmacist-led interdisciplinary transition of care service for high-risk cardiology patients across three tertiary Queensland hospitals. We hypothesise that this will help to reduce 30-day medication related readmissions to hospital.

This study is a stepped wedge randomised controlled trial aimed at investigating the implementation and clinical effectiveness of multidisciplinary post-discharge bundles on preventing readmission for older people transitioning from hospital to residential aged care for the first time. This will be carried out at multiple hospital sites in three local health networks in South Australia. Eligible patients will be stratified according to their risk of readmission and will receive a customized post-discharge bundle of interventions based on their assessed risk. The outcomes are 30- and 90- day readmissions after the index discharge and length of stay out of hospital. Process evaluation will include the acceptability, adoption, feasibility and fidelity of implementation.

The aim of this study is to determine the feasibility of giving ketone bodies in the form of dietary supplementation to patients with acute neurological injury admitted to ICU in order to improve neurological outcomes. This study will use be a randomised controlled trial, a well known study design that eliminates study biases that can confound findings as much as possible in order to determine the true utility of the use of ketones in brain injury. Patients who are in a coma with an acute brain injury, admitted to ICU, will be eligible to participate in this trial. Participants will be randomised (like the toss of a coin) to routine administration of ketone bodies via a feeding tube on admission and standard care, or placebo and standard care alone. Ketone body supplementation is currently not available for ICU patients and will only be available within this trial. Determining the feasibility of giving ketone bodies to patients with acute brain injury admitted to ICU is the first important step in a program of research that ultimately aims to test the efficacy of using ketone bodies in this group of patients to improve neurological outcomes and reduce disability.

We want to test smart shoes. We want to see if wearing these shoes decreases falls for people with Parkinson’s disease. We can monitor your walking at home when you wear these shoes. In this project we want to test a new way of obtaining objective measures of walking and falls risk in people with Parkinson’s Disease using novel technologies allowing continuous monitoring at home. For this pilot study we want to test the usefulness of such an approach using newly developed smart shoes (‘NUSHUs’, developed by our industry partner Magnes AG) with built-in sensors that study participants can use for walking or exercising at home. These shoes are not approved by the TGA in Australia. The shoes continuously record your mobility. The smart shoes collect data while you are walking or exercising and processes the data using advanced methods. During the study you will receive a training program tailored specifically to your individual needs to complete while wearing the smart shoes. The collected data can be accessed by the treating team so they can track your progress and guide you further via telehealth or in person reviews. By understanding how such a technique can be incorporated into clinical practice, this research will contribute to exploring modern management approaches for patients suffering from Parkinson’s Disease.