ANZCTR search results

The purpose of this study is the evaluate the activity and safety of a new investigational drug called Ampligen 'Registered trade mark' (poly l: poly C12U) in boosting the response to influenza vaccination.

Physiological monitoring of community patients with at-risk chronic heart failure randomised into one of 2-groups. Group 1 -Current management by the Sir Charles Gairdner Hospital Heart Failure Clinic including written Patient Education + Phone Support compared with Group 2 - Home computer recording of physiological measurements by the patient and centrally evaluated by the Trial Nurse / Doctor. We hypothesise that daily review of physiological parameters will facilitate early medical intervention and thereby reduce emergency department presentations and unplanned hospital admissions for chronic heart failure.

The aim of the study is to determine how well a once-weekly dose of Colocap Balance (magnesium sulfate) works in the treatment of chronic constipation. The study hypothesis is that a single, weekly dose of capsules, sufficient to create a strong urge to open the bowel and empty the bowel, will lead to an improvement in constipation symptoms, allow for a reduction in laxative use, and encourage the bowel to start working spontaneously between doses.

We plan to study 20 patients with idiopathic Parkinson's disease with complications of orthostatic hypotension and nocturia. In an 8 week double-blinded, crossover study design, we will study the effects of oral desmopressin (or matching placebo) on orthostatic hypotension, nocturia, and sleep.

The purpose of this study is to determine the effectiveness of delivering electrical stimulation in conjunction with traditional strength training in the quadriceps muscles of people with incomplete spinal cord injuries. The study will be undertaken over an eight-week period. This research can help physiotherapists understand how best to strengthen weak muscles in persons with incomplete spinal cord injuries. The quadriceps muscles are being used as a model to determine the effectiveness of regular electrical stimulation and strength training to all large muscle groups.

This study will provide ongoing supply of Cpn10 for people with RA who have participated in an earlier 6 month trial with Cpn10. Many treatments for RA lose their effectiveness over time and are associated with side effects that limit their use. The primary purpose of this study is to establish if Cpn10 is safe and effective in RA over a long period.

Pulmonary arterial hypertension (PAH) is a debilitating and life-threatening vascular disease affecting the lungs. Exercise training has traditionally had little role in the management of patients with PAH due to fears that it may cause disease progression and increase the risk of sudden death. However, this assumption may no longer be valid in patients who are stabilised on new medical therapies. We hypothesise that a supervised exercise training program conducted in the outpatient setting is safe and feasible, and improves exercise capacity, strength and quality of life in people with PAH. People with PAH will undergo 8 weeks of supervised exercise training in the outpatient setting. We will record any adverse events that ocfur during training. Before and after the training we will measure exercise capacity, strength and quality of life. the results of this study will indicate whether exercise training is safe for people with PAH and whether it has potential as a new treatment to improve exericse capacity and wellbeing.

The proposed study examines the impact of a specific telephone coaching intervention on HbA1C. HbA1C reflects average glucose concentration over ~3months. Secondary outcomes will include fasting glucose, lipids and blood pressure. Adherence to monitoring requirements will also be measured e.g. regular checks of HbA1C, lipids, feet & eyes. The intervention in question is currently in use in the cardiac population where its efficacy has been demonstrated by two Randomised Controlled Trials (RCTs).

This study is aimed to evaluate the role of acupuncture treatment for menstrual disorder in women with polycystic ovarian syndrome.

Patients undergoing ECT often experience postprocedure myalgia. There is also a published range of muscle relaxant doses to minimise this occurrence. It is the purpose of this study to compare the higher and lower recommended doses to see if there is a difference in postprocedure myalgia between the two doses.