ANZCTR search results

This study will attempt to identify potential clinical, histopathological and other novel predictors of survival outcomes in patients with malignant mesothelioma. Who is it for? You can join this study if you have a newly diagnosed malignant mesothelioma affecting your lung lining (pleura). Trial details: Participants with malignant pleural mesothelioma in all stages of disease will be recruited. Participants will be treated with the current standard medical therapy by the treating physician without study specific intervention. Participants will be consented for collection of their tumour tissue, blood samples and answering some questionnaires at baseline and subsequent follow ups.

The primary purpose of this study is to identify problems and obstacles to conducting a larger randmoised controlled trial that investigates the effect of weekend physiotherapy (in addition to weekday) compared to weekday only physiotherapy for inpatient rehabilitation patients. It is hypothesised that patients who receive the weekend therapy may achieve their physical goals earlier and have a shorter hospital length of stay.

The purpose of this study is to determine how safe and how well the human body tolerates transdermally delivered oxycodone combined with our patented technology (gel) in different patch forms. We would also like to see how much of the final product reaches the bloodstream after transdermal application.

The aims of this study are to show that patients with hypertension and abnormal left ventricular (LV) filling (but without coronary artery disease) may have their echocardiographic and biochemical markers of myocardial fibrosis and diastolic function improved by treatment with spironolactone, an aldosterone antagonist with anti-fibrotic properties.

The primary aim of this trial is to compare the outcomes and adverse events of two different physiotherapy treatment approaches for people with low back pain with or without sciatica. A secondary aim is to determine the perspectives of participants on the specific physiotherapy treatment program utilised in the trial.

In most labours, the baby is delivered head first, face downwards. When the baby is facing upwards, the labour may be more difficult, and assisted deliveries including suction cup, forceps, and caesarean section are more likely. When the mother is fully dilated, it is possible to perform an internal examination and to physically rotate the baby to the downwards (anterior) position, but it is unknown if this procedure reduces the chances of an assisted delivery. We plan to run a study looking at whether performing a procedure to turn the baby will reduce the risk of assisted delivery

This study seeks to determine the effect of application of cricoid pressure on the laryngoscopic view using a cMac video laryngoscope and secondly to assess if whether having the person applying the cricoid viewing the video feed assists in improving the laryngoscopic view.

Purpose of the study is to examine mother and baby outcomes following exposure to antidepressant medication during pergnancy. Patients will be asked to either continue antidepressant medication up until and after delivery; or to wean medication at 35 weeks of pregnancy and recommence at one week post partum. The primary hypothesis is the women who continue their medication through delivery will have fewer depressive symptoms. The secondary hypothesis is that babies exposed to antidepressant medication to term will be more likely to have discontinuation symptoms such as jitteriness and irritability

Achilles tendinopathy is a common condition that can cause marked pain and disability. Numerous non-surgical treatments have been proposed for the treatment of this condition, but many of these treatments have a poor or non-existent evidence base. This study is a randomised trial to evaluate the efficacy of customised foot orthoses to reduce pain and improve function in people with Achilles tendinopathy.

Effect of ventolin vs placebo in acute tetraplegic patients. Spirometric outcome measures