ANZCTR search results

The clinical trial would compare heroin use in a group of patients randomly allocated to receive unsupervised dosing with buprenorphine-naloxone to a group of patients remaining on wait list for a 12 week period (when this group would then be offered substitution treatment). The study will also assess adverse events that may be related to providing unsupervised dosing with buprenorphine-naloxone.

This project is part of a research program examining the efficacy of Internet based education and treatment programs for people with common mental disorders. This project compares the effectiveness of clinician-assisted Internet-based education for GAD vs. waitlist control at reducing the severity of symptoms of GAD. We expect that people who participate in the education program will report more benefit than participants in the waitlist control group.

This project is part of a research program examining the efficacy of Internet based education and treatment programs for people with social phobia and other commmon mental disorders. This project compares the effectiveness of different types of reminders and support at encouraging people with social phobia to complete the 6 lessons in the Program. We expect that people who receive telephone reminders (in addition to weekly emails and fortnightly smss) will complete a similar number of lessons and report similar benefit from the program as participants who do not receive the weekly phone call (but who do receive the email and sms reminders and receive access to the online forum moderated by a clinical psychologist).

The aim of the study is to test how effective an after-school physical activity and healthy eating program and a health education program are in the treatment of overweight and obesity in adolescents. To test these programs, the following two groups will be involved in the study: 1. A physical activity and healthy eating program; and 2. A state-of-the-art information-based health education program.

This study is a follow up study to a randomised control trial of a self-management program for people with bipolar disorder. We would like to see if participants receiving the program when delivered by mental health professionals in community settings (public or private) achieve similar outcomes to those involved in the first trial.

A global study to assess the safety and effectiveness of a potential new drug in comparison to the standard practice of dosing with warfarin in those patients diagnosis of Atrial Fibrillation

The aim of this research is to determine the effect of a 16 week progressive resistance training program (12 week supervised program and a 4 week home-based program) on female adults with Type 2 diabetes. Specifically, this study will focus on the measures of lower limb proprioception and strength, blood glucose levels and adherence to these programs.

Upper Abdominal Surgery (UAS) is a common surgical procedure, with average hospitalisation of 11.4 days. Breathing problems are a major contributor to longer periods of hospitalisation following UAS, and account for nearly 25% of deaths within 6 days of surgery. The incidence of such breathing problems following UAS is as high as 53%. There is a need for evidence-based approaches to reduce these rates, with potential benefits including reduced hospitalisation and healthcare costs, improved quality of care, and improved patient outcomes and quality of life. Research suggests that postoperative physiotherapy should be targeted towards high-risk patients, and is effective in reducing the incidence of breathing complications compared to no postoperative physiotherapy. However, potential benefits of additional preoperative physiotherapy for patients undergoing elective UAS have not been established. A randomised trial will be undertaken comparing current practice (postoperative physiotherapy only) to a program incorporating a preoperative physiotherapy session combined with postoperative physiotherapy. It is proposed that a single, preoperative physiotherapy session in the Pre Admission Clinic (PAC) setting would improve the quality of physiotherapy care for these patients. The aims of this preoperative session would be to: (a) Reduce the incidence of breathing problems; (b) Reduce patient anxiety during the first postoperative physiotherapy session; (c) Decrease the physiotherapist’s overall patient contact time, thus improving efficiency of the physiotherapy service. The study will investigate 4 questions: (a) Does preoperative physiotherapy reduce the incidence of breathing problems compared with standard management? (b) Does the timing of physiotherapy intervention (preoperative and postoperative vs. postoperative only) affect patient anxiety during the first postoperative physiotherapy session? (c) Does preoperative physiotherapy reduce overall physiotherapy contact time compared with standard management? (d) Should preoperative physiotherapy only be provided to patients at high risk of postoperative breathing problems?

BRIEF SUMMARY: Laparoscopy and hysteroscopy is a common day case gynaecological procedure. This operation involves keyhole surgery, inserting a small telescope-like device or fibreoptic lens into the abdomen via a 10mm port. This enables direct visualisation of inside the abdomen. There is also one other cut on the abdomen of 5mm, where a thin metal probe is inserted. Finally, a second fibreoptic device, is inserted inside the womb via the vagina and cervix, and the inside of the womb is visualised. A scraping of the womb tissue is taken and sent to the pathology laboratory to be analysed under a microscope. Patients usually go home the same day, unless there have been complications. Pain relief for this procedure has not been studied in any recent large trials. Current pain management involves use of pain relief tablets after the operation, and intravenous analgesics during the operation, including ropivacaine, depending on the anaesthetist. We aim to evaluate the use of intraperitoneal Ropivacaine. This is a local anaesthetic medication that can be squirted inside the abdomen at the areas that have been manipulated including the womb and fallopian tubes and injected at port sites, which are the two small incisions on the abdomen. HYPOTHESIS: We hypothesise that the use of ropivacaine at the end of the procedure will reduce post operative pain and hasten recovery after a diagnostic laparoscopy and hysteroscopy.

The aim of this study is to determine how clonidine affects the absorption of levobupivacaine in children having caudal anaesthesia for sub-umbilical surgery. Our study hypothesis is that the absorption of levobupivacaine will be affected when administered in conjunction with clonidine via the caudal route.