ANZCTR search results

A randomized study to demonstrate a difference in progression-free survival (PFS) for primary treatment with temozolomide in order to assess: whether PFS and OS can be prolonged by primary chemotherapy with temozolomide, whether the incidence of late toxicity can be decreased by using primary chemotherapy, the toxicity profile of the two treatments and the quality of life of the patients The impact of 1p deletions in low-grade gliomas: prognostic effect of tumors with deletion on PFS overall and by treatment group. Benefit for patients with LGGs and deletions treated with TMZ compared to radiotherapy alone with respect to survival. Interaction between treatment and cytogenetic features.

Knee pain is a common problem with 19-23% prevalence in people aged 40 and over. Frankston hospital has 138 patients awaiting knee replacement and a waiting time exceeding 18 months. Preliminary work suggest patient with anterior, medial and lateral compartment knee pain who have not had open knee surgery may obtain good but temporary pain relief and functional improvement from selectively anaesthetising the cutaneous nerves supplying the knee joint. This study seeks to validate the injection technique, determine which nerves need to be injected and which patients, pain patterns and pathology may benefit from this treatment or may benefit from a follow-on study of pulse radiofrequency treatment to these nerves.

The study will evaluate a new skin test device used for the diagnosis of cows’ milk or wheat protein intolerance. Diallertest® is a new type of allergy skin test designed for topical application (‘patch test’). Whereas standard allergy tests (‘skin prick tests’) measure immediate (IgE mediated) immune reactions to food and other allergens, the Diallertest® is intended to measure delayed (T cell mediated) reactions occurring 24-72 hours after exposure. Most participants will be recruited from amongst children who have been previously seen at the Allergy Unit and participated in a study of diet and nutrition in children with and without Autistic Spectrum Disorder (X03-0197). Some will be newly recruited from amongst those routinely attending the RPAH Allergy Unit for investigation of symptoms suggestive of non-IgE mediated food intolerances. Children with documented IgE mediated allergies to milk or wheat will be excluded. In order to determine the diagnostic predictive value of Diallertest® in this population, patch test results will be correlated with clinical history, skin prick test results, and oral food challenge results which have been done as part of clinical management. The results may also provide clues as to the mechanisms underlying intolerances to milk and wheat proteins observed in suitably selected children with and without ASD. The feasibility of using digital photography as a means of measuring and recording positive test results will also be evaluated.

Obstructive Sleep Apnea (OSA) is a common sleep disorder which is commonly treated with Continuous Positive Airway Pressure (CPAP). Up to 50% of individuals either do not take their CPAP treatments home or are not using them at 6 months. Preliminary data from CPAP patients found significantly increased uptake and usage >4hours each night with a Cognitive behavioural therapy CBT) intervention. Our aim is to compare TAU with the addition of a CBT intervention to TAU with the addition of Social Reciprocity to determine the effectiveness of CBT in improving CPAP treatment acceptance and adherence in OSA sufferers

This study aims to evaluate the impact of recalling patients to general practice for a visit to assess their risk of chronic disease and to help them to lower their risk by changes to smoking, diet, alcohol consumption and physical activity behaviours as well as pharmacological management of their blood pressure and cholesterol. Practices in the intervention group will receive training, practice visits, resources, and referral pathways to enable them to invite eligible patients to attend the practice for an assessment and management of their risk factors. This will include provision of education materials, support for behaviour change, referral to diet education and physical activity program and follow up.

This is a 12 month study seeking to enroll patients with symptomatic knee pain caused by osteoarthritis, who are bowlegged (with varus malalignment). The study will evaluate the safety of a new implant designed to realign the lower leg. Realignment can prevent further progress of osteoarthritis, decrease pain and allow individuals to return to more normal activity. In order to evaluate the safety of the system the study will collect information on any problems patients may experience during the surgery and recovery (up to 12 months), X-rays of the leg to evaluate bone healing and stability of the implant, and answers to surveys with questions about how patients are feeling and what their activity level is. This information will then be compared to a matched group of patients who had a high tibial osteotomy performed with a currently available metal plate and screw system.

Fatigue is a common problem and in many cases its cause cannot be medically explained. An understanding of the biochemical processes humans use to generate energy within the cells leads to a hypothesis to explain the cause of some forms of fatigue based on defective cellular energy processes. The active substance used in this study, GliSODin contains Superoxide Dismutase, an enzyme which may assist in the normal biochemical production of energy in human cells.

The aims of the current investigation were to assess the outcomes of an intensive burst of in-patient rehabilitation in ambulant people with mild-moderate PD and to compare the effects of movement strategy training and exercise therapy. It was hypothesised that movement strategy training would reduce disability to a greater extent than exercise therapy.

The primary purpose of the study is to assess the efficacy of the drug in reducing viral load in patients with chronic HCV infection