ANZCTR search results

Spinal Cord Injury (SCI) is a sudden and traumatic event causing permanent paralysis and ongoing disability. Respiratory dysfunction is a major cause of morbidity and mortality in SCI, causing reduced lung volumes and air flow rates. Some people living with quadriplegia (the loss of function in both arms and legs) are able to sing far more effectively than would be predicted on the basis of their injury level and severity alone. This study aims to determine the mechanisms by which these individuals achieve such impressive functional outcomes. Ten chronic cervical SCI subjects and 10 matched controls will be assessed during singing and speech using standardised phrases. Physiological tests including spirometry and EMG analysis will be utilised in addition to acoustic analysis of vocal amplitude. It is expected that in order to achieve the increased respiratory support required when singing, patients with quadriplegia will use innovative muscle recruitment and control strategies. The results of this investigation have important implications for therapeutic singing interventions during rehabilitation. Given that respiratory dysfunction is a major cause of morbidity and mortality after SCI, the effect of singing on respiratory function warrants further, rigorous investigation.

Random assignment to either Nissen or anterior 90 degree partial fundoplication. Outcome is reflux control and side effects (especially dysphagia)

Random assignment to either Nissen or anterior partial fundoplication. Outcome is relfux control and side effects (especially dysphagia)

Most children with leukaemia are cured, but those with the worst forms do less well. This trial is testing new ways of combining the most effective drugs, and adding a tranplant for children with the worst forms of leukaemia and a suitable donor. This tiral will determine if these new approaches could improve cure rates, and if they could be used more widely.

We believe that the use of N-acetylcysteine (a known mucolytic) will be useful in improving the diagnostic yield of sputum culture. If this hypothesis is proven, this agent can be recommend for this purpose.

Random assignment to either Nissen or anterior 90 degree partial fundoplication. Outcome is reflux control and side effects (especially dysphagia). Trial conducted in 6 cities in Australia and New Zealand

Review efficacy of giving rituximab on day 1 and 15 to see if platelet levels recover and how long a response last. Patients will attend regular visits for the collection of blood samples

This is a study on the safety and effectiveness of accelerated treatment with three chemotherapy drugs (bleomycin, etoposide and cisplatin with pegylated G-CSF) known as ‘accelerated BEP’, in treating people with advanced germ cell tumours. Who is it for? You can join this study if you have germ cell cancer that has spread to distant sites and is widespread. Trial details All participants will receive accelerated BEP chemotherapy intravenously over two week cycles. The number of cycles will be determined by the person’s risk of disease and their response to treatment. Accelerated BEP is a more intense treatment than the standard treatment, and may cause more side effects. This clinical trial will investigate the safety and efficacy of the new regimen as well as its impact on lung function, and neurotoxicity as rated by the participants.

Comparison of Argon plasma Coagulation with surveillance for the reversal of Barrett's oesophagus and the prevention of cancer in the oesophagus, in patients who are taking conventional medications for gastroesophageal reflux

Comparison of Argon plasma Coagulation with surveillance for the reversal of Barrett's oesophagus and the prevention of cancer in the oesophagus