ANZCTR search results

Hypotension occurs commonly following spinal anaesthesia. It is has been claimed that the standing posture prior to spinal anaesthesia may help prevent hypotension. The aim of this study is to compare two different postures prior to inducing spinal anaesthesia. One group of women will be lying down and the other group of women will be standing up prior to inducing spinal anaesthesia for caesarean section. We plan to measure any differences in the number of women requiring treatment for low blood pressure in the two groups.

We hypothesise that participants receiving a mechanically tensioned ACL graft have superior knee stability and hence function.

To assess whether nebulised heparin limits the extent of lung injury in patients with, or at risk of the acute respiratory distress syndrome.

People with diabetes and atherogenic dyslipidaemia who are treated with statin medication may still be at increased risk of cardiovascular disease and may require combination lipid regulating therapy to further reduce their risk. Endothelial dysfunction and increased arterial stiffness are present in early diabetic vascular disease and may be useful surrogate endpoints for cardiovascular risk. This 30 week, randomised double-blinded crossover study in 25 participants with diabetes who have endothelial dysfunction despite optimal statin therapy, aims to investigate whether combination therapy with micronised fenofibrate 145mg with no-food-effect orally once daily compared to matching placebo improves endothelial dysfunction.

The purpose of this study is to evaluate the effectiveness and safety of a new outpatient chemotherapy treatment for relapsed or treatment resistant (refractory) lymphoma.

The purpose of this study is to determine if SPL7013 Gel (VivaGel™) is safe when applied topically once a day for seven consecutive days to the shaft and glans of the penis in healthy male volunteers. The study will compare the safety of SPL7013 Gel on the penile epithelium and urethral mucosa to the safety of a placebo gel. The study will also assess the systemic safety of SPL7013 Gel, systemic absorption of the active ingredient of SPL7013 Gel, and the acceptability of the study products to the male volunteers.

Chronic foot wounds tend to take a long time to heal. In an attempt to heal these wounds, standard wound treatment involves the use of gel and foam dressings. This is the treatment you have been receiving so far. These dressings are designed to keep the wound moist but remove excess fluid, to promote the healing process. Vacuum-assisted closure therapy (VAC) is a relatively new treatment for foot wounds. VAC therapy involves the application of negative pressure (like a vacuum) to the wound through a little tube after the wound has been filled with foam and covered with a clear dressing. The vacuum sucks out any fluid in the wound and pulls the wound edges together. There has been some evidence that suggests this therapy assists wound healing. The VAC makes the wound site the best environment for healing to occur by removing the fluid, increasing blood flow and making the wound less suitable for bacteria to grow. The aim of this study is to see whether VAC therapy helps heal these stubborn wounds better than the standard therapy.

Chronic heart failure (CHF) occurs when the heart is unable to supply enough blood to meet the needs of the body. Common symptoms of CHF include breathlessness, fatigue and swelling of the lower legs. Clinical trials have shown several drug treatments (in particular, beta blockers) to be beneficial in reducing hospital admissions, and improving length and quality of life. In all the major clinical trials beta blocker therapy has been started and gradually increased to a target dose (or the maximum tolerated dose) over the course of several weeks. International and national expert guidelines recommend that patients with CHF be prescribed a beta blocker, however the benefits of beta blocker therapy cannot be assumed to follow when the doses used in the clinical trials have not been reached. For this reason it is important to ensure that patients receive the highest tolerated dosage. Also, there are data from some trials that suggest that the benefits of beta-blockade are detectable within the first few weeks. Thus any delay in the commencement and increase to maximum dose should be minimized. The aim of this study is to determine whether patients attending a specialist Nurse Supervised Titration Clinic reach higher doses of beta blocker sooner than patients receiving Usual Care. Usual Care involves visits to the Heart Function Clinic doctor every 3 months with visits to the GP in between.

The aim is to develop/evaluate a group behavioural program for parents that targets overweight/obese children aged 3 to 10 years. It is thought that participation will result in: reduced child BMI scores, reduced energy intake, reduced media viewing, increased activity levels; and reduced primary parent BMI scores. These changes are thought to be able to be maintained three months after treatment. Parental participation will hopefully result in improved parenting behaviour. These will be indicated by improved scores on parental self report measures of consistency, sense of satisfaction/efficacy and inter-parental conflict.

The purpose of the protocol is to provide people who not responding to current hepatitis B treatments another option.