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Exercise or advice for subacute low back pain
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NIVOAD Study: Non Invasive Ventilation in Obstructive Airways Diseases Study
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A clinical trial of manipulative therapy and/or NSAIDs for significant acute low back pain
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Multicentre Randomised Controlled Trial of Anterior vs Posterior vs Nissen Fundoplication
Multicentre prospective double blind randomized controlled trial comparing 3 surgical procedures for gastro-oesophageal reflux. All groups will undergo a clinically acceptable operation, according to standard clinical indications. The study will be performed in multiple centres throughout Australia and New Zealand. The study will be coordinated from FMC and RAH in SA. Patients will be recruited over a 2 year period. Follow-up will continue for up to 20 years.
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Does a single oral dose of dexamethasone after successful emergency department treatment of migraine reduce the incidence or severity of rebound headache within 48 hours?
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Comparitive Rehydration in Bronchiolitis
The need for supplying fluids in paediatric bronchiolitis (severe viral airway infection of the infant) is frequent, and is the consequence of reduced feeding, sweating, and fever., There are currently 2 means of supplying fluids, intravenous or nasogastric. Nasogastric rehydration (NR) means giving fluids through a feeding tube inserted through the nostrils into the stomach thus eliminating the effort of drinking. It is generally effective and has few complications. Intra venous rehydration (IR) means giving fluids directly into a vein through a drip. It is often difficult to insert a drip in this particular age group, whereas the nasal feeding tube is generally easier to insert. The potential complications of IR are water overload and electrolyte imbalances. The main possible complications of NR is vomiting. The role of NR in bronchiolitis is, however, controversial. It is, for example, an accepted treatment in Scandinavia and Switzerland, whereas IR is the accepted treatment at the RCH Melbourne. Even within Australia there is no standard of care as such among the different hospitals with most hospitals using a combination of NR and IR, without any guidelines. The little existing evidence shows that NR in bronchiolitis is safe and well tolerated. The major concern raised with NR is the partial obstruction of the airway, by cousing ablockage of the nostril in young children who mostly breathe through the nose, thus theoretically causing further breathing problems. But its clinical significance, especially in bronchiolitis, is not clear and has not been the subject of clinical trials. In this prospective study we will compare Nasogastric and Intravenous treatment in bronchiolitis.
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Cumberland McKenzie Trial
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Clinical trial of dermoscopy and digital monitoring in general practice
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Tenofovir versus Adefovir for the treatment of HBeAg negative chronic hepatitis B
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Tenofovir versus Adefovir for the treatment of HBeAg positive chronic hepatitis B