ANZCTR search results

This study will investigate the levels of pepsin (an enzyme normally found in the stomach and not in the lungs) in the exhaled breath (EBC) of patients with idiopathic pulmonary fibrosis (IPF) and compare them to levels recorded in healthy, matched adults. This information will help the understanding of whether pepsin (or other stomach contents) may contribute to the development of IPF

Research Aims: 1. To determine the effectiveness of the Triple P Online System (TPOS) and each individual TPOS variant (Triple P Online, Fear-Less Triple P, Triple P for Baby) on child and parent outcomes. 2. To examine the relationship between pre-intervention characteristics (moderators) and program outcomes (child and parent effects, module completion, and program satisfaction). 3. To identify predictors of responders and non-responders to TPOS interventions at each stage of the engagement and completion process (commencing the programs, completion of within-module activities, module completion and program completion). The Triple P Online System has been disseminated in Australia since 2014 and randomized controlled trials have shown that the system is effective in improving parenting practices, enhancing parenting efficacy and reducing child behavioural and emotional problems. Little is known however about its efficacy in a practice-as-usual context and about parents’ interaction with the program and the mediators and moderators that influence program outcomes. This study will take advantage of a roll-out of TPOS within Australia to collect data on effectiveness in a practice-as-usual context. The TPOS system has been funded for dissemination to all eligible Australian parents by the Commonwealth Government’s Parenting and Education Support Program from 2022. Continuous tracking of program outcomes embedded within the Triple P Online System interventions, will provide an ongoing quality management and improvement process. A mix of routinely collected Triple P Online System (TPOS) process data, mapped against parent and child characteristics and parent questionnaire responses pre, during and post program completion will track program effectiveness and allow rapid identification of specific areas for improvement. Tracking of module-by-module parent progress and program use will enable us to identify specific program components that are especially effective and engaging, as well as any that are less engaging and effective for parents.

The digital Covid Risk Calculator (CoRiCal) tool has been developed by a team of Australian GPs and epidemiologists in collaboration with the Immunisation Coalition to facilitate informed choice about COVID-19 vaccination risk and benefits: https://corical.immunisationcoalition.org.au. The study will be a randomised experiment, to investigate the impact COVID vaccine information on participants understand. The aim of this study is to improve the risk communication interface for CoRiCal, to ensure Australians with varying health literacy have access to updated evidence on COVID-19 vaccination benefits and risks in a form they can understand and act on. Key research questions will be: 1.Does the standard CoRiCal website output increase knowledge about COVID-19 vaccination compared to control 2.Do video explanations increase knowledge about COVID-19 vaccination compared to standard CoRiCal output 3.Does the absolute risk format increase knowledge and intention compared to 1 in x format This study is a survey which will be conducted online through the Qualtrics platform. Participants will be recruited from the general Australian public using a market research company, Dynata. Once they have read the PIS and Consent form and given consent, participants will complete a 10-minute survey. Participants will answer demographic questions and then will be randomised to receive one of three interventions or a control. This will take about 5 minutes to complete. Immediately following this, they will be asked our outcome questions, which will also take about 5 minutes to complete. Therefore the complete survey will take about 10 minutes in total. They will receive a debriefing document at the end to explain the aims of the study and that the data is based on current evidence but may not apply to their own situation, with references for reliable and updated information. Participants are told in the PIS that the results of the study will be posted on the research group website (https://sydneyhealthliteracylab.org.au).

Low back pain is a common problem, affecting over 4 million Australians every year. Advice, defined as any advice, education or information given by a healthcare professional to improve a patient’s understanding of pain or appropriate management, is recommended by guidelines internationally as a first line treatment for acute low back pain (pain less than or equal to 6 weeks). The goal of advice for acute low back pain is to reduce worries and concerns and to promote positive future healthcare behaviours. It is currently unknown which type of advice is best at reassuring patients with acute low back pain. The current approach recommended by guidelines involves providing information on the nature of low back pain and its generally favourable prognosis and encouragement to continue with normal activities (e.g. activities of daily living, leisure, and work) and avoid bed rest. Other approaches include pain science education-based advice and ergonomic-based advice. Pain science education-based advice aims to reframe unhelpful beliefs about pain by presenting information about the biologic basis and protective nature of acute low back pain. Ergonomic-based advice describes how postures and lifting techniques can contribute to a person’s acute low back pain and provides advice about how to reduce or prevent pain by maintaining good posture (e.g. when sitting or lifting objects).

This pilot study will assess the feasibility, acceptability and potential efficacy of a mobile health intervention among Out of School Hours Care (OSHC) services to improve staff health promoting behaviours, fruit and vegetable provision and physical activity environment. The study design is a parallel-group randomised controlled trial. The intervention involves a mobile application named The Eat Smart Play Smart App which is targeted at educator practices to address children’s healthy eating and physical activity. Investigators of the current project conducted a study to co-design an OSHC intervention with key stakeholders from the OSHC sector. During this study, stakeholders were presented with findings from a previously conducted state-wide quantitative survey of before and after school care services within NSW; and the stakeholders contributed to discussions around what support was needed to bring about meaningful change. The intervention piloted in this study has been developed through this collaborative process. It is hypothesised that OSHC services who participate in this intervention will increase their provision of fruit and vegetables in their OSHC service and educators from the services in the intervention group will have improved health promoting behaviours.

This project aims to examine the effect of Bruder Hygienic Eyelid Solution (Hypochlorous acid 0.02%) on ocular signs and symptoms, and eyelid microbiota in subjects with and without dry eye. This study seeks to examine: 1) The effect of a dilute hypochlorous acid (0.02%) spray on dry eye signs and symptoms and, 2) The correlation between eyelid microbiota and dry eye signs and symptoms. Study participants will attend two visits, an initial baseline visit and a 4-week follow-up visit. The OSDI score will be used to sort subjects into two groups: the dry eye group and the non-dry eye group. Participants scoring 0-12 points will be assigned to the non-dry eye group, whilst participants scoring above 12 will be assigned to the dry eye group. Both groups will receive Bruder Hygienic Eyelid Solution (Hypochlorous acid 0.02%) and participants will be instructed to use the spray twice daily on clean eyelids after normal face washing in the morning and night for 4 weeks.

The study aim is to explore the possibility of treating knee pain with focused ultrasound, optimise the study protocol and estimate the treatment effect in preparation for developing a subsequent clinical trial.

This study aims to assess the safety, tolerability and pharmacokinetics of a new cancer treatment, SGR-1505 that may be used for non-Hodgkin's lymphoma patients. The study will consist of multiple parts that will assess administration of SGR-1505 alone and in combination with another treatment, posaconazole. Who is it for? You may be eligible for this study if you are a healthy adult aged between 18 and 60 years old. Please note that this study will not be enrolling patients with non-Hodgkin's lymphoma. Study details The first sub-study will enrol participants and test single doses of SGR-1505. If a certain dose is found to be safe, a new group of participants will be enrolled to test a higher single dose of SGR-1505. The second sub-study will enrol participants and test multiple doses of SGR-1505 over a 10-day period. If a certain dose is found to be safe, a new group of participants will be enrolled to test a higher dose of SGR-1505 over a 10-day period. It is hoped this research will determine the safest dose of SGR-1505 that can be administered with non-Hodgkin's lymphoma

This study aims to: 1. Demonstrate safety and preliminary efficacy of psilocybin-assisted psychotherapy in reducing core eating disorder psychopathology and increasing motivation to change in AN as assessed by the EDE/EDE-Q and RMQ 2. Evaluate effects of psilocybin on depressive, anxious and obsessional symptoms, cognitive flexibility, quality of life and alliance between therapist and patient.

Transgender men on testosterone therapy may experience hair loss as a side effect, which can be distressing as it may not align with their gender expression. There are limited data as to what can be used to minimise hair loss in trans men. Minoxidil is approved to treat hair loss in cisgender population in topical form. The oral form has been used off-label in the cisgender population to treat hair loss as well. This study is conducted in a randomised, double-blinded manner using the sublingual form of minoxidil to see whether or not it will regrow hair on the scalp that can provide cosmetic significance and minimise distress. Furthermore, extension studies are done to assess sublingual minoxidil as a monotherapy and combined therapy. This can improve the quality of life for transgender individuals.