ANZCTR search results

The purpose of this study is to build machine learning and AI models to predict admissions to hospital from just information available at emergency department traige. We look to address current gaps in the literature by exploring the effect of concept drift and will attempt to address concept drift to try to make these models more applicable to the real clinical environment.

This study aims to determine the changes in blood glucose level control over six months following a simplified Mediterranean diet-based nutrition intervention compared to usual care among Australian adults diagnosed with type 2 diabetes. A healthcare practitioner in the primary care setting (GP or nurse) will deliver the intervention via telephone consultations and online media. Blood test results and other outcome measures of patients will be obtained from their registered general practice. We expect that patients receiving the nutrition intervention will have a greater improvement in blood glucose control, blood cholesterol levels, liver function, body weight and blood pressure compared to the patients in the usual care group.

This project looks at how daily actions (Things You Do; TYD) impact symptoms of anxiety and depression, in a sample of Australian health professionals. A Randomised Controlled Trial will compare three groups (n = 136 per group): TYD intervention vs. Gratitude intervention vs. Waitlist control condition. The two interventions conditions will follow a similar procedure beginning with reading instructions about the intervention condition, answering the same questionnaires, and receiving targeted SMS messages each weekday for four weeks. The primary objective of this trial is to compare the benefits of the TYD intervention vs. a gratitude intervention vs. a waitlist control condition on symptoms of depression and anxiety in Australian health professionals. Based on our previous research, the primary hypothesis is that nudging actions using SMS messaging will result in reduced symptoms of depression and anxiety in the two intervention groups relative to the waitlist control group, but that significantly greater improvements will be observed in the group who receive nudges based on the TYD model, compared to those receiving nudges based on gratitude information.

Hamstring strain injuries (HSIs), occurring primarily in the biceps femoris long head, have been shown to lead to an increased likelihood of re-injury. These injuries also lead to decreased muscle activity in eccentric contractions, persistent deficits in muscle architecture (i.e., the internal structure of the muscle) and motor pattern changes. Recent evidence also demonstrates that post injury, inhibition exists at the brain (or cortical) level. This inhibition can lead to reduced strength and changes in muscle architecture that can increase injury risk. The aim of this project is to investigate the effects of a strength training program combined with active or sham tDCS on cortical inhibition, hamstring strength and biceps femoris long head architecture. Our hypothesis is that muscle fascicle length and hamstring strength will increase more in the active tDCS condition rather than the sham condition.

A lack of validation data exists that compares the response of exercising individuals in different heat illness risk rating categories proposed by publicly available extreme heat policies for sport and exercise. The project aims to validate and inform publicly available extreme heat policies for long distance running by observing the heat strain of runners exercising in environmental conditions that are graded as moderate, high, and extreme environmental risk ratings according to the policies. We hypothesise that a progressively graded and higher response in thermoregulatory (core temperature), cardiovascular (heart rate), and perceptual measures (thermal discomfort) will be observed when moving from moderate to high to extreme risk environments. We also hypothesise that the extreme risk rating category will be associated with the participants approaching a core temperature response that is typically deemed as a 'cut-off' for exercise.

Water related recovery methods to treat hyperthermia (i.e. a highly elevated core temperature) are well understood, however dousing as a recovery method to reduce heat strain in contrasting humidities currently lacks experimental evidence. This study aims to build upon previous water dousing research by investigating the effect of water dousing upon the core temperature response following strenuous exercise in the heat under contrasting humidities. Based on theoretical data, we hypothesise that dousing in comparatively drier conditions will result in a greater decrease in thermal strain (core body temperature) compared to more humid conditions during recovery from exercise in the heat.

This study will evaluate whether delivering an exercise program virtually to childhood cancer survivors who attend Camp Quality community programs is effective at increasing physical activity levels and improving self-efficacy. Who is it for? Children aged 5-18 years old, who have completed cancer treatment and are not currently participating in >60 minutes of moderate-vigorous physical activity daily will be recruited to participate. Study details The intervention involves a 12 week individualised exercise program prescribed over five sessions with an accredited exercise physiologist, within a framework that includes age-appropriate aerobic, resistance, balance and flexibility exercises at a moderate intensity. The control group will receive education about the current paediatric oncology exercise guidelines, however will be offered to participate in the intervention at the completion of the study. Participants will complete questionnaires and physical assessments at various timepoints throughout the study. It is hoped that findings from this study will help inform researchers about the efficacy of virtually delivering exercise interventions to childhood cancer survivors in the community setting.

Advanced care planning is an important aspect of care of the elderly population. The study plans to investigate how comfortable patients and doctors are discussing this in the Emergency Department and to establish patient awareness, pre-existing advanced care directives, who patients and doctors believe to be the best person to discuss this with and identify any barriers towards discussion in the Emergency Department. By identifying these patient and doctor perceptions, we can improve discussion of advanced care planning and overall patient care.

This study is a first-in-human multi-center, Phase 1, randomised, double blind, placebo controlled study to evaluate the safety and tolerability of SKY-0515 in patients with Huntington’s Disease (HD). The study has 3 parts: Part C (i) a non-interventional observational arm and Part C (ii) where two dose levels (3mg and 9mg) will to be evaluated in HD patients and Part C (ii) Extension where two levels (9mg and 4mg) will be evaluated in HD patients. Part C (i): Participants will be required to attend 2 clinic visits over a period of 28 days. Health information and blood samples will be collected at these 2 visits. No treatment is given in this part of the study. Upto 50 participants will be enrolled. Following completion of Part C [i], participants will be invited to participate in the treatment portion of the study - Part C [ii], based on eligibility. Part C (ii): Enrolled HD patients will be randomised to 3 parallel treatment arms to receive 3mg study drug ,9mg study drug or placebo for a period of 1 to 3 treatment cycles (each cycle is 28days). Part C (ii) Extension: Enrolled HD patients who completed the last treatment visit in Part C(ii) will be offered to enter an Extension study for Part C(ii) and will be randomised to 3 treatment arms to receive 9 mg study drug (1st arm) 9 mg or 4 mg study drug (2nd and 3rd arms)

To assess the Tolerability and Safety of inhaled CMS and the profile while, comparing once daily (QD) with twice daily (BID) Administration for 28 days, The study will be measured by safety and respiratory tolerability events.