ANZCTR search results

This study is assessing the safety and efficacy of a new way of delivering radiotherapy, called Partially Ablative Body Radiotherapy (PABR), to tumours that are considered too bulky to treat with curative intent. Who is it for? You may be eligible for this study if you have a confirmed diagnosis of a non-haematologic malignancy not amenable to curative intent treatment, however are a candidate for palliative radiotherapy for a tumour size of at least 5cm. Study details Patients will undergo 5 sessions of radiotherapy on non-consecutive days over 2 weeks. The radiotherapy will be planned to deliver a higher dose to the core of the tumour and a lower, palliative dose to the periphery. Participants will have data collected on treatment related adverse events and tumour response to the radiotherapy, and will be asked to complete questionnaires on outcomes such as pain and quality of life. It is hoped that findings from this study will help develop PABR as a treatment modality for the palliation of bulky tumours.

In this study, we will assess the efficacy and safety of a dropless regimen in adequately controlling post-operative inflammation after cataract surgery. This study is a prospective, single-centre, non-randomized single-arm interventional study aiming to evaluate the tolerability of phacoemulsification without post-operative anti-inflammatory and antibiotics. This study will be conducted at the Royal Adelaide Hospital.

Patients with cardiac amyloidosis are known to have conduction disease, however, conduction disease is usually only identified once patients have developed overt heart failure. There is evidence to suggest that conduction disease may precede overt cardiac amyloidosis, providing an opportunity for earlier diagnosis and treatment of this condition.

This study aims to answer the question: Does use of a glucose telemetry system amongst hospitalised patients with diabetes mellitus treated with multiple daily injections of insulin improve glycaemic outcomes? Eligible participants will be randomised to the glucose telemetry system or to usual care. The glucose telemetry system will provide nursing staff with real-time glucose alerts to facilitate inpatient diabetes care. We will assess whether use of a glucose telemetry system improves inpatient glycaemia. We hypothesise that use of a glucose telemetry system in hospital will improve CGM-based glycaemic outcomes.

Within Gold Coast Health all patients who have their knee joint replaced (total knee arthroplasty) are referred for supervised outpatient physiotherapy after their surgery. This is in contrast to growing evidence that indicates that some patients who are having their knee joint replaced can achieve good post-surgery outcomes without the need for supervised outpatient physiotherapy, offering convenience and potential savings. The KAPPA criteria, previously established in a private sector cohort trial, demonstrated that simple and reproducible outcome measures assessed by a physiotherapist at two weeks post-surgery could determine which individuals could successfully continue with unsupervised rehabilitation versus those who would benefit from supervised outpatient physiotherapy. This project will validate these findings in a public health setting in patients who are undergoing knee joint replacement with the primary aim to compare the effectiveness and cost-efficiency of stratified physiotherapy using the KAPPA criteria with existing care through randomised methodology.

Physical activity (PA) is a promising intervention for children with ADHD that is safe, accessible, and effective in improving symptoms and mental skills. To maximise the effectiveness of PA programs for children with ADHD, researchers and clinicians need a better understanding of the brain mechanisms through which PA benefits children with ADHD. This information is essential for optimising treatment and will provide researchers with specific neurobiological targets for objectively evaluating PA interventions. The principal aim of this study is to examine the benefits of a tennis-based PA program on brain development, ADHD symptoms and mental skills in children with and without ADHD. It is hypothesized that PA will be associated with changes in brain development, ADHD symptoms and mental skills (executive functions). It is further hypothesised that PA induced brain changes will be associated with reduced ADHD symptoms and/or improved mental skills (executive functions) in children with and without ADHD.

A number of neurological disorders such as Parkinson’s disease (PD) are characterised by abnormal brain activity (e.g. unusually large numbers of neurons simultaneously active). Application of stimulation– in the form of mild electrical pulses or vibration – has been used as a therapeutic approach to reset the abnormal synchronous brain activity. ‘Peripheral stimulation’ involves the administration of non-invasive stimulation (mild electrical pulses or vibration) to patches of skin on the hands or feet. Early studies have shown that the use of a specific pattern of peripheral stimulation – called ‘coordinated reset stimulation’ – applied to the fingers, improved hand movements in patients with Parkinson’s disease, with benefits lasting several weeks. In this project, we aim to record the brain's response to ‘coordinated rest stimulation’ applied to the hands and feet in a group of healthy participants. This will assist in developing a future protocol for use with individuals with Parkinson’s Disease if indicated.

This study will investigate the safety and efficacy of low dose OIT (60mg of each nut protein) compared to standard dose multi-nut OIT (300mg of each nut protein) in children under 6 years old with one or more nut allergies. This study is a head-to-head, open label, randomised non-inferiority trial. A total of 208 children will be randomised 1:1 to low or standard dose multi-nut OIT, stratified by age and number of nut allergies. The primary outcome of this trial is sustained unresponsiveness to all nuts, defined as passing an oral food challenge to all nuts to which a participant was allergic at baseline, after completing 18 months of OIT followed by 8 weeks of nut avoidance. Secondary outcomes are desensitisation after 18 months of OIT (defined as passing an oral food challenge while still on uninterrupted OIT), safety, tolerability, feasibility, immune changes and patient-reported experience and outcomes of multi-nut OIT.

The low FODMAP diet is an effective symptom management approach for 50-75% of individuals with irritable bowel syndrome (IBS), leaving 25-50% as non-responders. Determining predictors of treatment response at the individual level during all three-phases of the low FODMAP diet are lacking. The aim was to investigate predictors of symptom response to the low FODMAP diet in patients with IBS. Adult IBS participants undertook the low FODMAP diet via one-on-one dietetic education including elimination, reintroduction and personalisation phases. Predictor variables included levels of depressive, anxiety, and extraintestinal somatic symptoms, stress, treatment beliefs and expectations, behavioural avoidance, and illness perceptions. Symptom severity and quality of life were the outcome variables. Questionnaires assessing psychological predictors, symptoms and QoL were completed at five timepoints: pre-dietitian (week 0), immediately post-dietitian, at the end of the elimination (week 5), reintroduction (week 13) and personalisation (week 25) phases. Statistical analyses will assess the predictive relationships between psychological predictors and symptom severity.

We aim to determine whether the My Emotions intervention, delivered by provisional psychologists in their usual work setting, is feasible, acceptable, and effective. Therefore, in this waitlist controlled randomised controlled trial, we aim to determine whether a brief emotions intervention delivered by provisionally registered psychologists: 1. Is feasible and acceptable when delivered in real life clinical settings (primary outcome) 2. Decreases emotions problems as measured by the Strengths and Difficulty Questionnaire (SDQ) at 3-months post randomisation follow-up (secondary outcome).