ANZCTR search results

There are two purposes to this trial. First, to assess the rate of change in axial length when wearing single vision contact lenses with an edge pattern against single vision contact lenses with no edge pattern. Second, to assess the rate of change in axial length when wearing single vision spectacle lenses with a spectacle film containing an edge pattern and adhered on top of the spectacle lens and single vision spectacle lenses with no spectacle film (i.e., no edge pattern). Axial length will be measured with a standard optical biometer. Contact lenses are made from ocufilcon D and spectacle films are made from polycarbonate. It is hypothesised that study products containing edge patterns will have a lower rate of change in axial length.

Trans young people often have poor mental health outcomes and high rates of depression and anxiety. These poor mental health outcomes have been shown to be associated with the abuse, rejection and discrimination that many trans young people experience due to anti-trans attitudes in broader society, referred to as minority stressors. This study will evaluate the Trans Adolescent Group ThErapy for Alleviating Minority stress (TAG TEAM) intervention, which is a group cognitive behavioural therapy (CBT) program that focuses on experiences of minority stress and aims to improve symptoms of depression and anxiety. The results of the study will be used to inform the clinical care of trans young people.

Osteoarthritis (OA) is the most common joint disease of the elderly, with knee OA more common than hip or ankle OA. Primary total knee arthroplasty (TKA) has been used successfully for decades to treat osteoarthritis. While a mechanical alignment (MA) of the prosthesis was initially pursued, this is increasingly being abandoned with the knowledge of the large variability of individual anatomy and knee biomechanics. New techniques involving patient-specific implantation techniques based on individual cutting guides and robotic-assisted implantation techniques have become more prevalent. While 3D-printed cutting guides are used to plan and perform osseous resections based on the individual bony anatomy, robotic-assisted techniques take into account the ligamentous stress ratios in flexion and extension. The purpose of this study is to determine whether planning based solely on the patient's bony anatomy achieves similar medial and lateral ligamentous tension ratios after total knee arthroplasty as a robotic-assisted technique that implements resections based on ligamentous tension ratios and bony anatomy.

This project will investigate a new, short-term mobility program known as the HiWalk program. HiWalk is a physiotherapy program provided at a time of need - meaning if the stroke survivor is experiencing challenges with their mobility or has a new mobility goal (even years after stroke), then this three-week program may assist their walking ability. Our preliminary research has demonstrated that HiWalk could be successfully implemented in the community after stroke and that the HiWalk program was enjoyed by people after stroke. The next, phase of research for the HiWalk program is a pilot trial of HiWalk allowing us to test the program in a clinical trial setting.

This study evaluates teledentistry and artificial intelligence (AI) in the screening of new orthodontic referrals as well as during braces treatment in Australian adolescents and adults. Its goal is to improve access to public orthodontic services. 208 participants will submit photos using a smartphone-compatible platform called Dental Monitoring (DM). Based on these, patients will have their elgibility status assigned according to NSW Health Policy. Participants will also be assessed at a face-to-face appointment. The outcome of these two methods will be compared to determine the validity of teleorthodontics. Patient satisfaction, oral hygiene status, gingival health status, reduction in waiting lists and the cost-effectiveness will also be assessed.

The primary objective of this program of research is to examine the acceptability and efficacy of videoconferencing delivered cognitive behavioural therapy (CBT) for social anxiety disorder. The secondary objective of this research project is to examine the efficacy of an imagery rescripting (ImR) enhanced cognitive behavioural therapy intervention for individuals with social anxiety disorder. It is anticipated that high-intensity videoconferencing delivered CBT will (1) be acceptable to individuals with SAD; (2) result in significant reductions in symptoms of social anxiety compared to waitlist control at post-treatment and follow up; (3) ImR enhanced CBT will result in similar reductions to standard CBT.

The intervention group will receive knowledge of results feedback during a physiotherapy session. Knowledge of results feedback is an objective measure of performance, for example, last session you were able to put 20kg through your leg for 15 out of 20 repetitions, this session you were able to put 20kg through your leg for 18 out of 20 repetitions. This information will be given to the participants immediately after each set of exercise repetitions within the treatment session and will be recorded on a recording sheet. The same type of knowledge of results feedback will be used for each exercise across sessions so that participants can see changes in their performance. The control group will receive usual therapy only which does not consist of the routine use of knowledge of results feedback. Change in motivation to practice and intensity or practice (,measured as exercise repetitions per minute) will be compared between the two groups to ascertain the effect of knowledge of results feedback. Hypothesis: The provision of knowledge of results feedback during therapy will increase stroke survivors’ motivation to practise and their intensity of practice.

Stiff Person Syndrome (SPS) is a rare disorder that causes pain, stiffness and spasms in the back, trunk, arms legs. It can be a difficult condition for doctors to diagnose as the key symptoms are common with many potential causes, and there is no single test that proves a person has the condition. Blood tests can be helpful in some cases and abnormalities in a particular test called the exteroceptive reflex test has been described in the condition. It is not known, however, how accurate exteroceptive reflex testing is in the diagnosis of SPS. The purpose of this study is to get more information about whether the exteroceptive reflex test can help doctors diagnose stiff-person syndrome and distinguish this from other neurological problems which present with pain or stiffness in muscles, people who take medication which make other reflexes more prominent (selective serotonin reuptake inhibitors and selective serotonin and noradrenaline reuptake inhibitors), and from healthy individuals. Exteroceptive reflex testing involves a doctor or neurophysiology scientist recording signals from several muscles in the back and legs by placing small disposable recording electrodes on the skin. Muscle contraction is measured after nerves in the wrist and ankle are activated with low-level electrical current. The test takes approximately 15 minutes, and does not cause any harm to the nerves, muscles or other parts of the body.

The primary objective of the study is to demonstrate of whether Avelle® Negative Pressure Wound Therapy helps better management of chronic wound and exudate when used in accordance with the Instructions for Use. Exudate is the fluid that leaks out of a wound. The secondary objective is to measure ongoing safety of the Avelle® Negative Pressure Wound Therapy system. Medications, drugs and devices have to be approved for use by the Australian Federal Government. The Avelle® Negative Pressure Wound Therapy System is approved in Australia to treat low to moderately exuding (leaking fluid) wounds that would benefit from a Negative Pressure Wound Therapy device. It is indicated to treat different types of wounds, one which is chronic wounds like ulcers. This study will gather information about the device’s ability to manage wound fluid and progress made in the healing of the wound. The hypothesis is that the Avelle™ Negative Pressure Wound Therapy system will help the wound close and manage the fluid that leaks from the wound. The hypothesis is that the Avelle™ Negative Pressure Wound Therapy system will help the wound close and manage the fluid that leaks from the wound.

Until recent years, right heart dysfunction (RHD) has been paid little attention due to a combination of it being challenging to assess, not having unified diagnostic criteria and the apparent robustness of the right ventricle. However more recent data combined with improved imaging techniques have changed this attitude. This project aims to create a longitudinal cardiopulmonary profile of patients who have suffered from right heart dysfunction to to determine if there is correlation between RHD and physical limitation/symptom burden following hospital discharge. It will use inpatient data (clinical and echocardiographic) as well as longitudinal outpatient data (qualitative and combined CPET-SE) to map the course of these patients. This longitudinal observational data will be hypothesis generating, a first step in considering how an acute phase intervention may change the natural history of this insult.