ANZCTR search results

Our objective is to find out if our planned series of five weekly online interactive workshops, called ENVISAGE - Service Providers (ENVISAGE-SP), is helpful to service providers’ practice, and supports service providers to empower families who have a child with neurodevelopment disability (NDD) to take a strengths-based approach to their child’s and family’s issues. We will recruit 80 service providers working with children with developmental challenges and their families in Australia or Canada. Conduct an open mixed-methods before-after pilot evaluation (data collected at 5 time-points – baseline, completion, and 3, 6, 12 months post-completion) to: (i) Evaluate (quantitatively) the impact of the ENVISAGE-SP program on SPs. (ii) Explore (qualitatively) SPs’ perceptions and experiences of the program (i.e., satisfaction, challenges), as well as the extent to which SPs feel the program has influenced their thinking (i.e., knowledge/attitudes) and activities (i.e., professional behaviours). (iii) Evaluate (quantitatively and qualitatively) implementation outcomes (i.e., acceptability, feasibility, adoption).

Intraoperative cell salvage (ICS) is increasingly accepted as a safe alternative to allogeneic (donated) blood transfusion (ABT) with the potential to reduce ABT related adverse outcomes and improve immune competence. Remaining obstacles include: 1) the risk of systemic bacteraemia in the presence of bacterial contamination from the surgical field and 2) the potential risk of systemic cancer cell dissemination during surgery for malignant tumours. When considering these specific obstacles (i.e., cancer and bacterial contamination risks), pelvic exenteration surgery is of particular clinical interest. These procedures aim to cure patients with locally advanced adenocarcinoma. Major blood loss, requiring massive blood transfusion, often occur. However, considering the nature of the surgical field, potentially contaminated with cancer cells and bacteria (from bowel content), ICS is not used. The C-I-ICS study, aims to assess whether ICS (processing and filtering) could reduce the risks of cancer cell and bacterial dissemination, into the patient’s circulation, when used during curative pelvic exenteration surgery.

The main aim of this research is to test the feasibility of a six-week combined exercise and nutrition intervention delivered to endometrial cancer patients before surgery. Who is it for? You may be eligible for this study if you are aged 18 years or older, you have been diagnosed with early stage endometrial cancer and you have an identified surgical risk factor including being overweight, having high blood pressure and/or high cholesterol, and/or type 2 diabetes. Study details All participants who choose to enrol in this study will be prescribed an exercise regime to follow for 6 weeks prior to their scheduled surgery to remove their cancer. The exercise regime will involve one weekly session with an exercise physiologist and two sessions at home, as well as a target level of exercise to complete each day, which may include walking/running, cycling or swimming. Participants will also be given options to follow a diet plan for six weeks prior to their surgery or to use Optifast products as meal replacements if it is safe for them to do so. It is hoped this research will provide important information to help endometrial cancer patients better tolerate the physical challenges of surgery and enhance their post-surgery recovery. If this study shows positive effects on post-surgery recovery, a larger trial enrolling a greater number of participants may be undertaken in the future.

This project is designed to investigate the impact of a social humanoid robot to deliver a low-intensity program about improving physical activity. It is intended that this trial will focus on how a robot can help people to increase their physical activity. This will include finding how the relationship the participant has with the robot will act to create variable outcomes in physical activity.

This study is a randomised controlled trial investigating the effectiveness of refeeding strategies post-competition in natural physique athletes. Athletes will be measured at baseline before beginning their competition preparation phase that typically lasts between 20-25 weeks. Following competition, they will be randomly allocated into one of the following nutrition strategies; ARM-1 Ad Libitum or ARM-2 Dietitian Intervention, to follow for 12 weeks post-competition. Primary outcomes assessed will included changes in metabolic rate and body composition. Investigators hypothesize that individualised dietetics intervention will result in faster recovery of physiological markers post-competition.

Poor diet is common and is associated with suboptimal outcomes for people with MS leading to higher health care expenditure. The impact of dietary patterns on disease incidence and progression in MS remains controversial with limited interventional studies. Moreover, the impact of improved diet quality on brain biochemical composition of MS has not been explored. This study intends to investigate the effects of improving diet quality in MS . Online telehealth dietary intervention by professional dietitians will measure diet quality and intake to ensure optimal dietary intake. A novel MRI method will be used to measure neurometabolites changes pre- and post-intervention which is able to assess the value of dietary improvement in an effective time frame.

Older adults have the lowest rate of mental health treatment in Australia. Access to evidence-based treatment is a major barrier. Online treatments can extend the reach of psychological therapies to those most vulnerable. This study aims to examine the efficacy, moderators and acceptability of an internetdelivered cognitive behavioural therapy (iCBT) program for older adults with anxiety and/or depression (Ageing Wisely Online), compared to a delayedtreatment waitlist control group. 68 older adults (aged over age 65) with an anxiety and/or depressive disorder will be randomly allocated to receive Ageing Wisely Online or to a waitlist controlled group. The Ageing Wisely Online program will consist of 10 iCBT modules, supported by brief 15-minute weekly therapist phone calls. Participants will complete diagnostic interviews and self-report measures at baseline, post-treatment and 3-month follow-up. With an internationally ageing population, these results will provide important information about alternate treatment delivery models for older adults with anxiety and depression.

This study sought to test the feasibility and limited efficacy of using textured insoles in children with motor coordination concerns following 4 weeks of use. Outcomes suggest there is support for running a larger trial with non-statistically significant trends showing greater improvements in balance outcomes for the insole group and greater endurance outcomes from the shoe alone group. The project was conducted in line with the protocol as approved by the University of South Australia HREC

Smoking is the leading cause of preventable death in people with severe mental illness (SMI). Although smokers with SMI want to quit, tailored interventions are rarely delivered in practice. This pilot feasibility study will assess the acceptability of the QuitPick intervention for smoking cessation among individuals living with severe mental illness. 30 participants who are accessing any treatment, support or care service for a mental health condition from Mind Australia Limited in Victoria will be recruited. All participants will receive the QuitPick intervention. Participants will be contacted by Quitline and offered a targeted smoking cessation counselling intervention with a choice of pharmacotherapy (NRT or NVP) and peer support over a 12-week period. Assessments will be conducted at baseline, 3 months (end of treatment), and 6 months (3 months post-treatment). After completing the QuitPick intervention, one-on-one semi-structured interviews will be conducted with 20 participants to investigate the experience of participants and understand acceptability of the intervention, with a focus on further enhancing engagement with the intervention.

Dialectical behavior therapy (DBT) is one of few evidence-based interventions for disorders of recurrent binge eating, yet few have access to this specialized approach. Translating DBT content for delivery via a smartphone application presents a scalable solution, yet no existing DBT app for recurrent binge eating exists. The aim of this trial is to test the efficacy of the Resilience application in individuals with recurrent binge eating. It is hypothesized that Resilience will produce greater improvements in all primary and secondary outcomes than the control condition.