ANZCTR search results

The primary purpose of the study is to evaluate the safety and tolerability of escalating doses of KER-065 administered as single and multiple subcutaneous doses in healthy adult volunteers.

Commonly used airway devices during general anaesthesia include supraglottic airway devices, of which best practice involves minimising the number of attempts at airway insertion to reduce patient morbidity. The intervention of this study involves the use of two additional pieces of airway equipment, a laryngoscope and bougie, to guide supraglottic guide insertion. The hypothesis is that this insertion method will increase the first attempt insertion success rate.

In this randomised, double-blind, placebo-controlled study, 80 adults experiencing anxiety will be randomly assigned to receive tablets containing either an echinacea extract (EP107) (40mg twice daily) or a placebo for 7 days. We will assess changes in anxiety using the State-Trait Anxiety Inventory and sleep quality using the PROMIS Sleep Disturbance and Sleep-Related Impairment Scale. These questionnaires will be administered at regular times before, during, and 2 weeks after stopping tablet intake.

The purpose of this study is to assess the safety and therapeutic effects (how well a treatment works) of ILYX-002 for the treatment of Dry-Eye Disease. This study will be conducted in patients with Autoimmune Disease, aged 18-85 years old. This study will compare ILYX-002 with vehicle/placebo. A vehicle is a medication with no active ingredients. It looks similar to the real thing, but it is not. One group of participants will receive ILYX-002 and the other group will receive the vehicle/placebo. The effects seen in participants receiving the study drug will be compared to the effects seen in participants who receive vehicle/placebo. Each group will involve approximately 55 participants, with 110 participants to be enrolled in total.

Social media has transformed communication and during the pandemic has had an alarming influence on public health communication. For example, younger adults and those with greater social media use showed higher endorsement of misinformation and lower support for official health advice provided during the global pandemic in Australia and worldwide. This study aims to develop and assess the effect of an online health literacy intervention on critical appraisal of online information. Participants will receive the intervention either via TikTok-style videos, animated videos, or informative written materials. Outcomes will be compared between the conditions.

We hypothesize that gastric emptying is accelerated to a greater extent when blood sugar falls rapidly compared to slowly. Hypoglycaemia triggers counter-regulatory mechanisms to restore blood sugar by accelerating gastric emptying. It is not known whether the rate of onset of hypoglycaemia impacts gastric emptying acceleration. Accordingly we will study type 1 diabetic patients, and induced either rapid or slow hypoglycaemia using insulin clamps. We will record gastric emptying after a standardised radiolabelled meal. This study may show that slow onset hypoglycaemia requires treatments that bypass the oral route.

In this study , we will be investigating whether there is an association between waiting time, symptom duration, patient-reported outcome measures (PROMs), and physical function for individuals on an orthopaedic surgical waiting list. We will be determining the reliability and validity of using wearable sensors and an instrumented treadmill to collect walking patterns, by comparing it to the current reference standard of optical motion capture.

A feasibility cohort study will be conducted to assess the feasibility, acceptability, and appropriateness of a mobile application “OA Coach”. The intervention is a mobile application that will be used to provide education about osteoarthritis. Participants will also be provided a wearable activity tracker (Fitbit) to track their steps and complete daily physical activity goals. Participants will be asked to use the app daily (total time is up to participant discretion) for 6 weeks.

BARISTA is a prospective, multi-centre bacterial genomics study of invasive Staphylococcus aureus infections that is currently recruiting the Austin Hospital and Royal Melbourne Hospital in Melbourne. Adult patients admitted for a monomicrobial sterile site infection (eg. blood, bone, or joint) are included, with up to a year follow-up. The study collects all clinical samples with growth of S. aureus (blood cultures but also bone, muscle, joint), and samples from recurrent infections within a year. Nasal swabs are collected at enrolment and after 6 and 12 months and in case of recurrence. EDTA blood is collected to extract cell-free DNA (cf-DNA).

This research is conducted to initially diagnose Cancer of Unknown Primary (CUP) at the DNA level using Somatic molecular profiling and tissue of origin assay and to measure the implementation of Optimal Care Pathway (OCP) . Who is it for? You may be eligible to join this study if you are aged 18 years and older, have suspected or confirmed CUP diagnosis and no prior treatment for CUP Study details All participants in this study will have treatment according to the optimal care pathway along with the use of tissue of origin classifier and comprehensive somatic mutation profiling. Participants will be asked to sign a consent form. Access to your health records may be required to help interpret the results; therefore, your participation will involve giving us permission to collect information about your cancer diagnosis and use of health services. This research will be monitored by Flinders Medical Centre Medical Oncology Department Clinical Trials unit. Participation in this study involves somatic molecular profiling and tissue of origin test which will be described in detail below. Somatic molecular profiling and tissue of origin assay Cancer cells have changes in their DNA (the "instruction book" for the cells in your body) that cause uncontrolled growth. When you were diagnosed with cancer, you had a piece of tissue removed from your tumour(s) (called a “biopsy”) to confirm what type of cancer it is. Testing on the tumour (somatic molecular profiling) may help identify where your cancer started. Furthermore, the test may identify genetic changes in your cancer that may respond to anti-cancer medicines. Your doctor may then tailor your treatment accordingly. Treatment in this research project will be determined and given by your treating doctors. The trial does NOT provide treatment. Participants will be followed-up every month to assess the outcomes of the matched/recognised therapies in participants. It is hoped that this research project might or might not improve your health but the information that is learned may help other people who have a similar medical condition in the future.