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Abatacept and Infliximab in Combination With Methotrexate in Subjects With Rheumatoid Arthritis
Expand descriptionThe purpose of this clinical research study is to learn if Abatacept or Infliximab in combination with Methotrexate demonstrate a greater reduction in disease activity over placebo.
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Pharmacokinetic Characterization of Intramuscular Olanzapine Depot
Expand descriptionThe goals of this study are to: Determine the blood levels of intramuscular (IM) olanzapine depot in patients at different points in time after an injection, and compare these levels to the amount of olanzapine in the blood of patients after treated by oral administration with Zyprexa (olanzapine) tablets or by intramuscular administration with Zyprexa IntraMuscular (olanzapine for injection).
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Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT)
Expand descriptionThe purpose of this study is to determine whether treatment with etoposide, doxorubicin, cisplatin and mitotane (EDP/M) prolongs survival as compared to streptozotocin and mitotane (Sz/M) in patients with advanced adrenocortical carcinoma (ACC) whose disease is not amenable to complete surgical resection.
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A Treatment Protocol for Patients With Gastrointestinal Stromal Tumor (GIST) Who May Derive Benefit From Treatment With SU011248
Expand descriptionThe purpose of this study is to permit access to SU011248 for treatment use by patients with GIST given the following conditions: a) patients undergo screening, but are not eligible for participation in ongoing clinical studies such as A6181004; AND b) patients have GIST which standard treatments have not been able to control with acceptable toxicity AND c) patients have the potential to derive clinical benefit from treatment with SU011248.
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Levosimendan Versus Dobutamine in Shock Patients
Expand descriptionThe purpose of the study is to compare the efficacy of levosimendan with that of dobutamine in patients with unstable hemodynamics (shock).
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Major Depressive Disorder In The Elderly
Expand descriptionThis is a placebo-controlled study evaluating the effectiveness of medication in elderly subjects with Major Depressive Disorder (MDD).
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HP184 in Chronic Spinal Cord Injury Subjects
Expand descriptionThe purpose of this study is to determine whether HP184 is effective in the treatment of chronic spinal cord injury (CSCI).
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Study of Viramidine to Ribavirin in Patients With Chronic Hepatitis C Who Are Treatment Naive
Expand descriptionThe purpose of this study is to determine the safety and effectiveness of viramidine to ribavirin in chronic hepatitis C patients who have never before received treatment.
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Insulin Resistance Intervention After Stroke Trial
Expand descriptionThe purpose of this study is to determine if pioglitazone is effective in preventing future strokes or heart attacks among non-diabetic persons who have had a recent ischemic stroke.
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Efficacy and Safety of Oral Bosentan in Pulmonary Arterial Hypertension Class II
Expand descriptionThe present trial investigates a possible use of oral bosentan, which is currently approved for the treatment of symptoms of pulmonary arterial hypertension (PAH) Class III and IV, to patients suffering from PAH Class II.