ANZCTR search results

Approximately, 70-85% of children with ADHD are affected by sleep disturbances, often leading functional impairments. Behavioural symptoms of disrupted sleep include bedtime refusal, night-time awakenings, excessive daytime sleepiness, and inconsistent sleep onset and awakenings from sleep. Within children with ADHD, behaviour-focused interventions have been shown to improve sleep problems, with studies citing reductions in bedtime resistance, sleep onset delay, and daytime sleepiness. Furthermore, studies have reported improvements in moods, emotions, and social interactions following interventions. This study will expand on current research using the Sleeping Sound intervention to assess efficacy of online delivery compared to previously researched in-person delivery in a novel RCT.

The aim of this study is to test the effectiveness of a personalised and contingency-based approach to managing individuals at risk of suicide in an Australian veteran community sample. The study will use a cluster randomised control design to compare the effectiveness of a personalised and contingency-based approach to treatment as usual (TAU), for reducing distress, decreasing suicidal ideation and behaviours, increasing treatment engagement and improving safety plan quality and connection to supports. The study will also explore whether a) the change in safety plan quality (post intervention – baseline) is greater for those receiving a personalised and contingency-based intervention compared to TAU, b) whether the change in safety plan quality partially mediates treatment response and c) whether the effectiveness of implementation for clinicians incorporating a personalised and contingency-based intervention improves treatment response. For this research, the personalised and contingency-based approach being utilised is the SafeSide Framework for Recovery-Oriented Suicide Prevention. Noteworthy in this study design, the clinician training, not the client’s treatment is randomised. Clinicians will be grouped according to location and randomised to commence training at two time points, six months apart. A comparison of intervention effect and control condition between groups will occur during this period, as well as an assessment of implementation effectiveness.

This pilot study will provide a patient centred, pragmatic and individualised process liberating children from mechanical ventilation. The pilot phase of this study will determine feasibility of the trial protocol, randomisation, time to recruit and sample size for the larger multicentre randomised controlled trial (RCT) that will follow. This pilot phase will determine feasibility, efficacy, clarity and agreement by investigators on protocol, and allow testing of randomisation with ability to improve all for the larger RCT.

Participation in rehabilitation that targets specific goals and functional abilities after stroke can be challenging for people living in the community. Many stroke survivors find it difficult to find ways to stay motivated to participate in therapy and achieve their goals. This study aims to determine whether a different structure of therapy, an intensive program of therapy sessions supported by a multidisciplinary team and self-management approach, can be successfully implemented for community stroke survivors. The study will also determine the opinions of stroke survivors about the program and observe if there are changes in mobility and goal achievement after participation.

This clinical trial will investigate a new type of scan called 18F-DCPYL-PET which provides whole body images of prostate cancer spread, in patients that have had a negative biopsy. We propose that in men with a high clinical index of suspicion for prostate cancer, 18F-DCPYL-PET may be a successful tool to aid early diagnosis of prostate cancer.

The aim of this project is to evaluate the efficacy of an online training program for mental health clinicians. The training is called Men in Mind, and focuses on engaging male clients in therapy and responding effectively to men’s distress and suicidality. The project will also evaluate the cost of the intervention per user. The online ~8 hour, 5 module training program has been developed in consultation with international experts in men’s mental health, and is designed to be a leading evidence-based resource for clinicians to develop skills and knowledge in male-specific adaptations to treatment. The project represents a partnership between Movember (leading the delivery of the intervention), and Orygen/Centre for Youth Mental Health, The University of Melbourne (leading the evaluation of the intervention). The online data management system will be managed by our sub-contractor, Strategic Data Ltd. The effectiveness of Men in Mind will be evaluated in a waitlist-controlled randomised superiority trial. Intervention group participants will complete self-report and vignette-based assessments before the training, and 6 weeks after they complete the training, in addition to 3-months / 12-weeks follow-up. Control group participants will receive access to the training following a 6-week waiting period, and after completion of pre-training and post-waitlist assessments. The primary outcome will be whether Men in Mind training participants, relative to waitlist control participants, display more greatly improved self-reported capacity to engage male clients at 6 weeks post-training according to the Engaging Men in Therapy Scale (EMITS).

The BXT-786 System used as part of a standard genicular block (block of the knee region) could provide a more effective (potentially reduced pharmaceutical analgesic intake) benefit for patients with unrelieved pain from knee osteoarthritis that are undergoing, or who meet the criteria for, total knee arthroplasty (TKA). (Note: it is not required for the subject to actually have a scheduled TKA, just that they meet the criteria for the procedure). The administration of the BXT-786 Focused Cold Therapy creates a physical effect in the specifically targeted peripheral nerves. without permanently damaging the nerve or injuring surrounding tissues. Based on previous research, it is anticipated that the analgesic effect may last weeks to months. This will allow for the benefit of temporary analgesia without damaging the nerve through a minimally invasive treatment. Over a 12 week period, subjects will participate in live and Telehealth visits, as well as complete a subject diary to aid in the assessment of the research block's safety.

One cause of unsuccessful implantation of high-quality embryos during IVF treatment is inadequate endometrial production of the beneficial cytokines LIF and VEGF, both known to assist embryo development and attachment. Our hypothesis, based on positive results from preliminary in vitro experiments, is that application of a copper containing gel to the uterine cavity before ovulation will upregulate the endometrium’s production of LIF and VEGF around the time of a later embryo transfer, thereby augmenting implantation success. The primary objective of this study is to determine the optimal dose of copper for up-regulation of endometrial LIF/VEGF without causing any safety concerns for the study participants. Secondary study outcomes include assessment of uterine fluid copper content and the influence of this fluid on embryo (mouse) development in vitro.

Motor neurones are a specific type of neurone that connect our muscles to our central nervous system (brain and spine). Thanks to motor neurones we are able to transform electrical impulses generated in our brain into muscle contractions, translating into strength and movement. Motor neurones have the ability to do this through a phenomenon called persistent inward currents (PIC). Research has shown that in the presence of serotonin, PICs are facilitated, and thus strength is achieved easier. Apparently, caffeine may influence the development of PICs in human motor neurones. Yet, the degree at which caffeine affects PIC and movement is still unknown. Therefore, we are testing the effects of caffeine on PICs, strength development and time to fatigue. We hypothesized that the consumption of caffeine will increase PICs amplitude, increasing levels of force and diminishing fatigue.

The purpose of this research is to examine the effects of protein supplements on serotonin levels, mood, cognition, fatigue, sleepiness and parameters of muscle strength. Your participation will involve: 3 morning testing sessions of ~ 3 hours each to the Exercise Physiology Research Laboratory at QUT, Kelvin Grove campus. Each visit will consist of questionnaires of sleepiness, mood, cognition, neuromuscular testing on your calf muscles, the consumption of a supplement and repeating all testing plus performing a muscle fatigue protocol.