ANZCTR search results

The objective of this study is to investigate the effect of an internet-based self-help intervention program on seizure frequency for individuals with functional seizures. The first aim of this project is to develop an internet-based therapy for patients with functional seizures. To assess this new therapy, patients with a documented diagnosis of functional seizures will undertake a 5-week e-intervention, called re-PROGRAM, either guided by a therapist or on their own, followed by standard care. A third group of participants will receive standard care, which involves an appointment with a psychiatrist every 6 weeks. A goal of the research is to find out whether undertaking re-PROGRAM is more effective than standard care, and whether undertaking re-PROGRAM while guided by a therapist provides any further benefit to patients than engaging with the program with limited therapist contact. The second aim of this project is to assess the cognitive function and behavioural characteristics in patients with functional seizures and to identify predictors for successful treatment outcomes. Establishing why some people respond to treatment better than others will assist in developing more tailored therapy approaches and provide a better understanding of patients’ therapy experiences.

To evaluate the effect of an intervention comprising a coordinated and integrated medication management service (Home Medicines Review HMR)) provided for patients in primary Care with Osteoporosis (OP) and Minimal Trauma Fracture (MTF). This intervention aims to improve the medications patients are taking to minimise their risk of falls and improve their bone strength.

Evidence suggests that health coaching is an effective approach to encourage healthy lifestyle habits, including physical activity engagement. These healthy lifestyle changes have been shown to improve patient outcomes and reduce personal healthcare expenditure and care-seeking. Telephone-based health coaching is a promising and emerging intervention for chronic low back pain and has shown to improve physical activity and enhance expectation of recovery in physiotherapy patients. In chiropractic settings, this approach is novel and has the potential to optimise the effectiveness of chiropractic care and encourage patients to take up healthy lifestyle habits through a telephone-based mechanism of support alongside their chiropractic care. Chiropractic patients will participate in a health coaching feasibility study, which will inform the potential for a larger interventional study to explore effectiveness and offer long-term patient engagement with healthy lifestyle habits, such as physical activity. The health coaching intervention includes chiropractic patient participants receiving a patient-centred physical activity plan developed with the advice of the health coach. This physical activity plan will specifically suit patient needs and preferences. Participants will be encouraged to develop goals to suit and gradually increase their physical activity. Health coaching will involve up to 5 individual online / virtual session. We hypothesise that participants in the health coaching program in addition to receiving concurrent usual chiropractic care, will demonstrate improved levels of physical activity, function and reduced levels of pain and rate of care­seeking for low back pain. We also hypothesise that participants will build healthy lifestyle habits, and potential to positively impacting physical and mental health, quality of life and healthy ageing.

The aim of this study is to investigate the effects of daily consumption of gold kiwifruit on psychological health and other health related outcomes including biochemical parameters, and gut symptoms in adults aged 18-60 years with symptoms of anxiety and depression. Gold kiwifruits contain exceptionally high levels of vitamin C. vitamin C is recognised for its important role in mood, cognition and physical health and wellbeing. Gold kiwifruit has the potential to infer beneficial effects on the constructs of psychological wellbeing and aspects of physical health. The CSIRO will lead a 10-week randomised crossover trial involving daily delivery of gold kiwifruit in adults experiencing current psychological distress.

The INFINiTE-CV2 Phase IIa trial aims to assess whether nasal delivery of an Interferon (IFN -1)/ Hyaluronic Acid formulation improves clinical course of COVID-19 infection and viral clearance. This study is being performed to address an unmet urgent clinical need for a simple effective treatment for a pathogen of global health significance. It is hoped that this treatment is shown to be safe and effective with potential implications for both treatment and prevention of COVID-19.

The aim of this randomised controlled trial is to increase adoption of the lunchbox nutrition program ‘SWAP IT ’in primary schools located in the Central Coast Local Health District. This trial will evaluate whether a theory-based multi-component dissemination strategy targeting barriers to adoption can improve the adoption rates of the nutrition program. Schools will be randomly allocated to receive either a month multi-component dissemination strategy over a 3 month period, or a minimal intervention control group. Intervention effectiveness will be determined by comparing, relative to control, the absolute difference in the proportion of schools adopting the program at 6-month follow up. The trial aims to generate evidence regarding the effectiveness of strategies to inform broader dissemination of the lunchbox nutrition program.

The current study aims to evaluate whether Goodnight Poor Sleep, a brief sleep intervention, improves sleep, daytime functioning and mental health outcomes in university students.

The aim of this study is to compare glycaemic control with 50, 90 and 130 g carbohydrates per day in people with type 2 diabetes and to test whether a 90g carbohydrate reduction is enough to improve time in range (3.9-10 mmol/L) and decrease time above range (>10 mmol/L) compared to the commonly used lower carbohydrate definitions of 50g and 130g carbohydrates per day for the management and treatment of T2D (hyperglycaemia) through diet.

The aim of this randomised controlled trial is to increase adoption of the lunchbox nutrition program ‘SWAP IT ’in primary schools located in the Hunter New England Local Health District. This trial will evaluate whether a theory-based multi-component dissemination strategy targeting barriers to adoption can improve the adoption rates of the nutrition program. Schools will be randomly allocated to receive either a month multi-component dissemination strategy over a 3-4 month period, or a minimal intervention control group. Intervention effectiveness will be determined by comparing, relative to control, the absolute difference in the proportion of schools adopting the program at 6-month follow up. The trial aims to generate evidence regarding the effectiveness of strategies to inform broader dissemination of the lunchbox nutrition program.

For women with a BMI>40, or a BMI 30-40 and one or more comorbidities, continuous electronic fetal monitoring via cardiotocograph (CTG) monitoring, is recommended (RANZCOG 2019). Conventional forms of CTG monitoring require the labouring woman to wear two tight elastic belts around her abdomen and to be tethered to a machine by wiring, thus restricting her mobility. A wireless and beltless monitoring device, the non-invasive fetal electrocardiogram (NIFECG) was registered by the Therapeutic Goods Administration (TGA) for clinical use in Australia in 2018. The aim of this study is to determine how the use of an innovative monitoring technology, NIFECG, in women with increased BMI, compares with the current standard monitoring, CTG in: • Detection of fetal distress requiring intervention • Fetal scalp electrode (FSE) use • Maternal feelings of control and agency during labour and birth • Capacity for midwives to provide woman-centred care. Using the results of both the quantitative and qualitative data that will be collected, the study will also explore barriers and facilitators to implementation of the NIFECG as routine care for women with increased BMI. Hybrid RCT Type 1 methodology, following the approach of Curran et al. (2012), uses a hybrid effectiveness-implementation typology. The study design therefore enables a dual focus a priori, testing the effectiveness of a clinical intervention on specified outcomes whilst also synthesising implementation needs. The RCT will be conducted at three clinical sites in Australia. The sample size is 450 women.