ANZCTR search results

The primary aims of this project are to determine the effects of high intensity progressive resistance training (PRT) on the number of alcoholic drinks consumed per week, measured using a 7-day recall in adults who have undergone rehabilitation for alcohol use disorder with mental health comorbidities. Participants will be randomised to receive either PRT, 3 days per week for 12 weeks after discharge into the outpatient program in addition to usual care provided in the outpatient program at St John of God (Burwood) Hospital, or usual care in the outpatient program only at St John of God (Burwood) Hospital. Participants randomised to the control intervention will receive usual care in the 12-week Alcohol, Drugs and Addictive Behaviours outpatient program at St John of God (Burwood) Hospital. We will not advise on treatment. Blinded assessments will occur pre-, and post intervention. Unequal randomisation will be used to minimise drop-out rates, in a ratio of 2 participants randomised to the intervention group and 1 to the control group. For this trial we have conservatively estimated an effect size of 1.1. With a beta 0.8 and alpha of 0.05, a total of 32 participants will need to be recruited, 11 participants in the control group and 21 in the intervention group, to show significant effects for the number of drinks consumed per week.

This study aims to measure the architecture and mechanical properties of soft tissues of the human body as they are stretch or compressed using the magnetic resonance (MR) imaging technique of MR elastography. MR elastography uses an MRI scanner to capture the propagation of vibration through the soft tissues. In this study the vibration will be generated by a new ‘gravitational’ transducer. We hypothesise that there will be differences in the mechanical properties of these soft tissues during these loading conditions, from which we can quantify the large deformation tissue mechanical properties.

This clinical trial is designed to compare the efficiency in the removal of interdental plaque and interdental gum.. Participants are instructed on how to use each device correctly and safely. We use plaque and bleeding scores to determine which healthbrushes and an oral irrigation device (water flosser) to clean in between your teeth.

StandingTall-with our Mob is culturally-safe and tailored to Aboriginal Australians, and has shown excellent indicative success in pilot research studies. It considers underlying social determinants of Indigenous health and well-being whilst meeting evidence-based guidelines to safely and sustainably advance healthy ageing through exercise, cognitive training and stress reduction. The program combines home-based and group-based sessions with traditional and technology-driven methodologies across three key components: (i) a home-based exercise program offering balance exercises through mobile technology; (ii) a home-based cognitive-motor program focusing on training executive function, attention and working memory using a dual-task paradigm through mobile technology, and (iii) a group mindfulness-based stress-reduction program, to improve social and emotional well-being and reduce the impact of stress through cultural connection. This project comprises a cross-over style trial to determine adherence and effectiveness of our holistic healthy ageing program in 100 older Aboriginal people (aged 45+ years) over 6-months. We hypothesise that our holistic, multifaceted program will lead to improved mobility, cognitive function, and quality of life in Aboriginal Australians. Principles of inclusiveness and attendance flexibility, and acknowledgment of Aboriginal culture are incorporated in all activities.

The aim of this study is to compare invasive (meaning it is done from inside the body) assessment of blood flow through the large and small arteries of the heart to the heart muscle (via angiography) and a single proton emission computed tomography with low dose CT (SPECT/CT) scan assessing the same thing. This is because SPECT/CT assessment of blood flow to the heart through small arteries is a relatively new technology that we would like use more if the results of this study deem it to be accurate. Presently it is difficult to assess whether there are abnormalities of the small arteries of the heart, which is a common cause of chest pain in people who are diagnosed as having “normal coronary arteries”. The only way to do this currently is with an invasive test, using special pressure wires to measure blood flow in the small arteries. This would mean that patients with chest pain could have a SPECT/CT scan alone rather than an angiogram (requiring a procedure with inherent risks) to investigate their symptoms. Involvement in this study involves addition of a pressure wire test to the normal heart angiogram procedure, along with a SPECT/CT scan. Additionally, participants will be checked in on at 1 and 12 months following their tests to assess their progress, whether they have had any heart problems, how their symptoms are, and whether they have had any further tests or diagnoses. This will all help to assess how useful the SPECT/CT scan will be in the future.

Approximately, 70-85% of children with ADHD are affected by sleep disturbances, often leading functional impairments. Behavioural symptoms of disrupted sleep include bedtime refusal, night-time awakenings, excessive daytime sleepiness, and inconsistent sleep onset and awakenings from sleep. Within children with ADHD, behaviour-focused interventions have been shown to improve sleep problems, with studies citing reductions in bedtime resistance, sleep onset delay, and daytime sleepiness. Furthermore, studies have reported improvements in moods, emotions, and social interactions following interventions. This study will expand on current research using the Sleeping Sound intervention to assess efficacy of online delivery compared to previously researched in-person delivery in a novel RCT.

The aim of this study is to test the effectiveness of a personalised and contingency-based approach to managing individuals at risk of suicide in an Australian veteran community sample. The study will use a cluster randomised control design to compare the effectiveness of a personalised and contingency-based approach to treatment as usual (TAU), for reducing distress, decreasing suicidal ideation and behaviours, increasing treatment engagement and improving safety plan quality and connection to supports. The study will also explore whether a) the change in safety plan quality (post intervention – baseline) is greater for those receiving a personalised and contingency-based intervention compared to TAU, b) whether the change in safety plan quality partially mediates treatment response and c) whether the effectiveness of implementation for clinicians incorporating a personalised and contingency-based intervention improves treatment response. For this research, the personalised and contingency-based approach being utilised is the SafeSide Framework for Recovery-Oriented Suicide Prevention. Noteworthy in this study design, the clinician training, not the client’s treatment is randomised. Clinicians will be grouped according to location and randomised to commence training at two time points, six months apart. A comparison of intervention effect and control condition between groups will occur during this period, as well as an assessment of implementation effectiveness.

This pilot study will provide a patient centred, pragmatic and individualised process liberating children from mechanical ventilation. The pilot phase of this study will determine feasibility of the trial protocol, randomisation, time to recruit and sample size for the larger multicentre randomised controlled trial (RCT) that will follow. This pilot phase will determine feasibility, efficacy, clarity and agreement by investigators on protocol, and allow testing of randomisation with ability to improve all for the larger RCT.

Participation in rehabilitation that targets specific goals and functional abilities after stroke can be challenging for people living in the community. Many stroke survivors find it difficult to find ways to stay motivated to participate in therapy and achieve their goals. This study aims to determine whether a different structure of therapy, an intensive program of therapy sessions supported by a multidisciplinary team and self-management approach, can be successfully implemented for community stroke survivors. The study will also determine the opinions of stroke survivors about the program and observe if there are changes in mobility and goal achievement after participation.

This clinical trial will investigate a new type of scan called 18F-DCPYL-PET which provides whole body images of prostate cancer spread, in patients that have had a negative biopsy. We propose that in men with a high clinical index of suspicion for prostate cancer, 18F-DCPYL-PET may be a successful tool to aid early diagnosis of prostate cancer.