ANZCTR search results

For patients that undergo pancreas and kidney transplantation there is a risk of bleeding during and after the operation, one way of reducing this is identifying potential sources of bleeding during the preparation of the organ before we implant it into the patient. One solution called Methylene Blue can highlight these sources of bleeding, therefore we will want to conduct a research project to determine if this will reduce the risk of bleeding.

This study will investigate the effect of same day dual endoscopy on finding common gastrointestinal conditions for patients referred for assessment of positive Fecal Occult Blood Test (Bowel cancer screening test) Who is it for? You may be eligible to join this study if you are aged 50 and above, and have been referred for investigation of positive Fecal Occult Blood Test (Bowel cancer screening test) Study details: All participants in this study will have two endoscopy procedures on the same day: an upper (gastroscopy) and lower (colonoscopy) as part of the routine clinical care for patients with a positive fecal occult blood test. We would also access your electronic medical records so we can confirm your diagnosis and test results. The findings from both upper and lower endoscopy will be used to evaluate occult GI bleeding. Participants will not be asked to attend any additional appointments, outside their scheduled clinical visits. This study therefore has no effect and no foreseeable risk of harm to its participants. No attempts at directly contacting the patient or their family will be made. All the relevant findings from the endoscopy (both gastroscopy and colonoscopy) will be discussed with the participants by their gastroenterologist. It is hoped these findings will provide further guidance/evidence to support the routine use of both upper and lower endoscopy for the evaluation of occult GI bleeding.

We are doing a research project to evaluate the feasibility of a Virtual Clinical Pharmacy Service (VCPS) that is being delivered via video link to patients admitted to an elective orthopaedic ward at Royal Prince Alfred Hospital located in Sydney NSW. The aim is to explore if a service can be implemented, if it will detect potential medication errors and if it is acceptable by patients and hospital staff. Routine data collection from patients' electronic medical record will help to measure the success of the VCPS.

Intestinal sweet taste receptors (STRs) sense all sweet stimuli to coordinate the absorption and metabolism of glucose. We have shown that a defect in intestinal STRs in patients with type 2 diabetes (T2D), as well as supplementation of low-calorie sweeteners in non-diabetic subjects, both accelerate glucose absorption and worsen glycaemic control. We now propose to block intestinal STRs in patients with T2D to evaluate the potential glycaemic benefits of this potential 'next generation' diabetes therapy.

Otopure Pty Ltd in collaboration with ResMed is undertaking this study to generate a uniquely valuable data set that includes a statistically significant number of volunteers providing informed consent for prospective CT scanning that will allow for the generation of a Statistical Shape Model (SSM) of the head that incorporates the face and the upper aerodigestive tract. These SSM models will be able to generate usable, realistic geometry in any of these forms in a matter of minutes. The primary objective of this study is to generate a statistical shape model (SSM) of the head and airway in order to improve treatment for patients with OSA.

The MyCoach (COnnected Advice for Cognitive Health) clinical trial aims to test the effectiveness of an e-learning course designed to support healthy brain ageing and reduce risk of dementia, tailored for people living with mild cognitive impairment or subjective cognitive decline. The e-learning course provides information on memory impairments and dementia, memory strategies, and the association of different lifestyle factors (diet, physical activity, social and cognitive activity, and stress) with brain ageing. The course is complemented with additional practical support for healthy lifestyle change, and the components combined run for 12 weeks. The MyCoach intervention will be evaluated against a control group receiving general education. We will be evaluating the effectiveness of MyCoach at improving dementia risk scores, cognition, as well as healthy ageing outcomes.

This study is investigating whether known (already identified) or new potential biomarkers found in blood or tissue can be used to detect colorectal cancer, or to predict the outcomes of patients who have been diagnosed with colorectal cancer. Who is it for? You may be eligible for this study if you are aged 18 or older, you have confirmed colorectal cancer or benign (non-cancerous) bowel disease or you are healthy without any history of bowel disease (cancerous or benign) Study details All participants who choose to enroll in this study will be asked to provide up to 6 blood samples over a 5 year period. Participants who have confirmed colorectal cancer will be asked to allow research on tissue collected at surgery or colonoscopy for 5 years post consent. Participants who have confirmed cancer will also be asked to share their medical history and any new test results with the research team to determine how the disease is responding to treatments provided. It is hoped this research will identify new biomarkers that may be used to improve health outcomes for colorectal cancer patients, either by allowing earlier detection of cancer, or by allowing detection of people who have a genetic risk of cancer so that they might take steps to reduce their future risk of developing cancer.

Total knee arthroplasty (TKA) surgery is considered the gold standard procedure for symptomatic knee osteoarthritis, and in line with increasing osteoarthritis rates, TKA surgery is also projected to rise. Traditionally, TKA was associated with a long and extensive physical recovery, and supervised physiotherapy was considered routine. Recent peri-operative advancements and rapid recovery protocols have meant that TKA patients regain functional independence much sooner and are less reliant on formal rehabilitation. However, despite this progress, some patients still have suboptimal functional outcomes or self-reported dissatisfaction when their rehabilitation is self-directed, and are then subsequently referred by their orthopaedic specialist, or self-seek, supervised physiotherapy. The aim of the Knee Arthroplasty Physiotherapy Pathways (KAPPA) trial is to determine which patient variables are associated with poor physical or self-reported outcomes after undergoing self-directed physiotherapy. If patients at higher risk of suboptimal outcomes can be identified, then early referral to supervised physiotherapy can be implemented.

We propose a study which is first of its kind in Australia/New Zealand with an aim to objectively assess the role of performing a paracervical block in reducing postoperative pain and enhancing post-operative recovery following benign indicated laparoscopic hysterectomy. Paracervical block with 0.5% Bupivacaine (with adrenaline) has been previously tested as a potential strategy to optimise post-operative pain management following total laparoscopic hysterectomies (TLH). However, data in this regards remains scarce. Our proposed study aims to conduct objective evaluation of pain by measuring opioid intake post-operatively as well as by determining the impact of paracervical block in patient reported pain beyond the first 24 hours postextubation. In addition, we also attempt to determine subsequent impact on return to normal activity. The proposed study is a two-arm single centre double blinded randomized placebo-controlled trial. We believe this study will not only add to the current body of limited evidence but will also assist in planning and implementation of methods to improve perioperative pain management, maximise enhance recovery after surgery, and increase patient satisfaction. The potential overall impact in cost efficacy and economic gain is also worth consideration. Drug used in trial: The medication that we will examine and use in ‘treatment’ group is 0.5% Bupivacaine with Adrenaline. This is a TGA approved drug, with a well-established safety profile, frequently used in a number of gynecological procedures, and readily available in the institution where the trial will be carried out.

Present trauma interventions are limited in that they tend to be designed for children diagnosed with PTSD. This study aims to test an intervention that is suitable for children who have experienced trauma but are experiencing a wide range of symptoms. We want to see whether this treatment is acceptable to children and their parents, whether it is effective at reducing mental health symptoms, and whether it prevents future difficulties associated with trauma such as suicide and psychosis symptoms. We are also interested in what mechanisms the treatment may work through (e.g., emotion regulation).