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Exercise performance is impaired in hot conditions compared with temperate conditions. During exercise in such thermally stressful conditions, fluid loss through sweat production to liberate heat from the body is accelerated, which can adversely impact cardiovascular and thermoregulatory function and ultimately hinder exercise performance. To increase the total fluid pool available for sweat production, ingestion of nutritional aids such as glycerol and sodium prior to exercise may increase total body water above normal body water levels (i.e., euhydration) prior to exercise, which is known as hyperhydration. This topic requires further investigation to determine if hyperhydration is a viable preparation strategy for endurance running in hot conditions. The hypothesis for this study is that the combined ingestion of glycerol and sodium will result in a significantly greater fluid retention than the control and this will improve half-marathon time-trial performance in hot ambient conditions.

Paediatric patients undergoing cardiac surgery or inpatient in the intensive care unit at the Royal Children’s Hospital in Melbourne (RCH) will have a study pulse oximeter (Contec Pulse Oximeter, model CMS50DL) placed on a digit when an arterial blood gas is being drawn for routine clinical management. At this time, the patient’s vital signs and specific values from the arterial blood gas measurements will be recorded and, ultimately, the usual RCH pulse oximetry readings and arterial blood gas co-oximetry values will be compared with study pulse oximeter readings. All paediatric patients undergoing cardiac surgery at RCH during the specified time period will be eligible and may be subjects in this study. Patients and/or the patient’s legally acceptable representative will be provided with a study information sheet. Verbal consent will be obtained for all patients. Patients and/or the patient’s legally acceptable representative will also be asked to fill out a survey as part of the study. Study hypothesis: We are conducting this study to test whether a low-priced pulse oximeter (a medical device to measure the amount of oxygen in the blood) is accurate in paediatric patients, particularly those undergoing cardiac surgery.

Whole Brain Radiotherapy (WBRT), Stereotactic RadioSurgery (SRS) and NeuroSurgery (NS) have been used to treat brain metastases (BM) for many years. There has not been any research that tells us which is the best way to use these treatments for individual patients with BM. At present, any combination of SRS, NS and WBRT is considered acceptable. This research aims to evaluate whether changing the sequence of two routinely offered treatment options (SRS and NS), will improve the management outcomes of patients with brain metastasis. Who is it for? You may be eligible for this study if you are aged 18 years or older, have been diagnosed on MRI of the brain with metastatic brain tumours amenable to a combination of SRS / NS and have a life expectancy of greater than 6 months. Study details All participants will first receive SRS; a standard non-surgical radiation therapy used to treat small tumours of the brain, using precisely focused radiation beams. SRS is not surgery in the ordinary sense, because there is no incision involved and general anesthesia is not required for adults. Treatment will involve an MRI/CT planning session taking approximately 1 hour each, followed by initiation of treatment within 1 week of planning. SRS will be delivered face-to-face in the radiotherapy department. Each treatment session will take up to 1 hour covering initial treatment set-up through to treatment delivery. The number of treatment sessions could range between 1 and 5 sessions delivered over a 1 week period. The number of sessions are based on the size, location, and number of brain metastases. All participants will undergo NS 1-3 days after completion of SRS, An MRI scan is routinely performed 2 days after NS to assess the outcome of the operation. Follow-up of participants will occur at 1 month and 3 months after treatment completion, as well as 3-monthly for the first year after treatment and 6-monthly for the second year after treatment. Follow-up involves surveillance MRI imaging, assessing for side effects of treatments / complications and the efficacy of the treatments. Trial participants will be invited to participate in the optional translational sub-study involving the collection of blood and tissue samples for molecular/laboratory evaluation before treatment, during SRS, after treatment completion and at the time of post treatment disease progression. After the sub-study is completed, any remaining blood and tissue samples collected, will be 'banked' or stored for future research. How may the study impact practice? It is hoped that this approach will decrease the risk of short and long-term complications, in addition to improving the chance of controlling the tumour in the cavity left in the brain after removal of a brain metastasis by NS. The results of this study may also help clinicians to determine which initial treatments to offer people with brain metastases in the future.

Induction of labour (IOL) is one of the most frequent obstetric interventions, being performed in more than 100,000 pregnant women in Australia every year. The first phase of IOL consists of preparation of the cervix, which is often done with the placement of a balloon catheter through the birth canal for 12-24 hours. This procedure is effective, safe and generally performed in hospital. This study will not only investigate whether cervical ripening with a balloon catheter can be performed safely and effectively at home after insertion in hospital, but also establish a network of obstetric services in Australia. If we show that cervical ripening with a balloon catheter can be safely and effectively performed at home, this will reduce significantly the number of admissions and healthcare costs.

The purpose of the study is to evaluate a product called Tranexamic Acid (TXA) and its best use in patients who are undergoing total knee replacement. The product is currently used to reduce bleeding during and after surgical procedures. This can lessen the chance of a blood transfusion and may decrease pain, swelling and recovery time following the operation. Tranexamic Acid is already routinely used by surgeons for patients having joint replacements but there is currently no accurate information about how to dose individual patients with this medication to achieve the best results. This study will assess whether different treatment durations and doses will lead to better patient outcomes. The form of TXA that we are using in this study is one single dose in the vein-intravenously and/or an oral tablet. There are 2 treatment groups: Group 1 –Receives 1 gram of TXA intravenously 1 hour prior to surgery Group 2 – Receives 1 gram of TXA intravenously TXA 1 hour before surgery and post-operatively oral dose of 2 grams 8th hourly for a total of 6 doses.

The West Australian Heart Valves Study (WAVES) aims to improve patient outcomes in valvular heart disease. The study aims to achieve this via two separate components: 1) A registry that includes data linkage of mortality and hospital morbidity records of all patients who have had a heart valve replacement and/or repair in one of the 3 tertiary public hospitals in Western Australia since 2010 and 2) An observational cohort study of all living patients in the registry to determine health outcomes, medication use and patient reported outcomes such as quality of life, functional capacity and life disability.

The most common spinocerebellar ataxia worldwide, Machado-Joseph disease (MJD) has the highest estimated prevalence in affected Aboriginal communities of the Top End of Australia. MJD, or spinocerebellar ataxia 3 (SCA3), is a rare autosomal dominant neurodegenerative disease that leads to progressive ataxia and functional decline. The ‘Staying Strong Toolbox’ is a physical activity and lifestyle program designed by Aboriginal families living in Groote Eylandt and Ngukurr, to keep their families walking and moving around. Families with MJD in these communities who were concerned about their declining mobility partnered with the MJD Foundation and university researchers to co-design the Staying Strong Toolbox, based on their experiences and what is known from MJD research. The aim of this study was in order to determine the feasibility and impact of the Staying Strong Toolbox program on walking and moving around for Aboriginal families with MJD in the Top End of Australia. A mixed method multiple case study design was used to pilot the Staying Strong Toolbox. Eight individuals with MJD participated in the program for four weeks. Participants tailored their own program using the Toolbox workbook. Families, support workers and researchers facilitated each individual’s program. Feasibility was determined through program participation, adherence, coinciding or serious adverse events, participant acceptability and cost. Impact was determined through measures of mobility, ataxia, steps, quality of life, wellbeing and goal attainment, assessed before and after the program.

Endometriosis is a common and chronic condition. Whilst deep forms of the disease (ovarian endometriomas and deep-infiltrating endometriosis) are reliably diagnosed on ultrasound prior to surgery, superficial pelvic disease is not. This pilot study aims to assess a new ultrasound measurement to determine its accuracy in diagnosing superficial endometriosis. Patients scheduled for key-hole surgery will undergo pelvic ultrasound 1-2 months before surgery, then standardised surgical samples of the uterosacral ligaments (fibrous bands originating at the lower uterus) will be analysed. Should this ultrasound measurement be successful, it will improve diagnostics for endometriosis, and guide which patients may benefit most from surgery.

Deep brain stimulation (DBS) is an established treatment for Parkinson’s disease (PD) and has been shown to improve the symptoms and quality of life of patients with this condition. The effectiveness of DBS relies on applying DBS therapy to an ‘ideal’ location to achieve maximal symptom improvement. This ‘ideal’ location is dependent on where the DBS lead is implanted during surgery and where the doctor choses to apply DBS therapy along the lead after surgery. Electrical signals recorded in the brain during DBS surgery may help doctors in identifying: 1) the ‘ideal’ location to implant DBS leads during surgery and 2) the ‘ideal’ location to apply DBS therapy after surgery. Evoked resonant neural activity (ERNA) is a new electrical brain signal that has been recorded from DBS leads during surgery in patients with PD. ERNA holds significant promise as an electrical brain signal that could guide DBS lead implantation during surgery and assist doctors in selecting the ‘ideal’ location to apply DBS. However, the reliability of recording ERNA signals in the brains of patients with PD is unknown. Therefore, the primary purpose of this study is the establish whether the ERNA signal can be reliably and safely recorded in the brains of patients with PD during DBS surgery. The secondary purpose of this study is to determine how the ERNA signal relates to the location of the DBS leads in the brain and the response of the patient to DBS therapy.

MovingTogether is a health promotion program for socially isolated, older adults that targets modifiable risk factors including physical inactivity and balance to improve mental and physical health outcomes. The program is delivered online, through a private Facebook group. Allied health professionals e.g. exercise physiologists and a dietician provide education, individual guidance and promote social connection within the group. Topics covered include increasing physical activity, decreasing sedentary behaviour, healthy eating, goal setting and balance training. The balance training portion of the program is covered by the inclusion of NeuRA’s StandingTall app. Our previous pilot study demonstrated feasibility, acceptability and preliminary effectiveness. With the general protocol maintained and improvements made to program design since, we hypothesise that the program will be effective in comparison to a control group.