ANZCTR search results

In this randomised, double-blind, placebo-controlled study, 140 adults with self-reported cognitive complaints will be randomly assigned to receive capsules containing either a Grape/Blueberry extract (150mg twice daily) or a placebo for 24 weeks. A computer-based assessment and several validated clinician-administered and self-report measures (to be completed at various time points throughout the study) will be administered to assess change in cognitive performance, mood, and quality of life. Changes in urinary and plasma concentrations of specific metabolites from the phenolic compounds from Grape/Blueberry extract will also be examined.

An RCT will be conducted across multiple community AOD services to examine clinical setting implementation and efficacy of the QuikFix risk-targeted intervention for reducing alcohol and other drug use and related harm in young people. The intervention is designed to address how individuals with specific psychological risk factors cope with their susceptibility to AOD misuse, with an intention to change specific AOD-related behaviours. While the efficacy of this risk-targeted intervention has been demonstrated for alcohol, its efficacy for reducing AOD use and related harm when delivered as part of real-world clinical practice is yet to be determined. Participants will be young people aged between 16-25 years, who have recently presented to a support service located at a SNP, festival or schoolies celebration with an AOD-related injury or illness, or to an AOD community service. Participants will be randomised to receive either (i) online assessment with feedback (AF) or (ii) the telephone-delivered risk-targeted QuikFix brief intervention which includes AF, motivational interviewing (MI) and cognitive-behavioural coping skills training.

Young people entering our colleges are most likely about to start drinking more frequently, and at higher levels, than ever before in their life. While they are entering one of the most fun and exciting periods of their lives, where social events, partying and clubbing will happen almost daily, they most likely are not aware that in the next few years, they are more likely to see or personally experience adverse alcohol-related consequences (social embarrassment, alcohol poisoning, violations of law, and more). It is therefore important for first year college students to be warned of the risks that come from using alcohol, and educated about what they can do to ensure their college experience remains safe and positive. The QuikFix brief intervention has been successfully trialled with young people experiencing AOD use problems; however, it has not yet been evaluated among university students living within the college environment. Further, the indirect effects of the QuikFix intervention on peer social networks remain unclear. It is therefore necessary to determine if the QuikFix brief intervention is effective in socially influential first year college students and college peer leaders, and if the individual benefits of QuikFix to these influential students, spread to other university students through their social networks. If effective, this method could maximize the diffusion of alcohol interventions to large groups of young people in an efficient and cost-effective way (Ott, Light, Clark & Barnett, 2018). The overall objective of this research is to determine if the QuikFix College program is effective in reducing risky AOD use and related harms among UQ college students. The QuikFix College program seeks to educate all students through delivery of the QuikFix AOD Harm Minimisation Workshop, and then assess the effect of an additional QuikFix Brief Telehealth Intervention.

The current trial will focus on developing and implementing a trauma-informed model of care (TIC) that is suitable for young people with alcohol and other drug (AOD) problems accessing residential services. The trial will have 4 phases: Trial development, implementation, evaluation, and sustainability. Phase 1 will co-create a new model of trauma-informed care with AOD staff and clients. Phase 2 will implement the new model of care through staff training, support and supervision. The TIC will be integrated into the existing AOD group treatment program, along with a therapeutic milieu emphasising a ‘shared language’ between clients and staff around client coping and personal strengths, and reward positive behaviour. Individual trauma treatment will also be offered to eligible clients. Phase 3 will evaluate the new model in both staff and clients. Phase 4 will assess whether this new model is sustainable and continued once the trial has ceased.

This trial is investigating the feasibility, acceptability, and effectiveness of an educational intervention, Reboot Kids, delivered to parents of childhood cancer survivors aged 2 years or older. Who is it for? You may be eligible for this study if you are a parent of young cancer survivors aged 2 to 16 years old, recently off treatment Study details Parents will be randomly allocated (by chance) to one of two arms. Participants in the intervention arm will be invited to fill out one online questionnaire and complete one telephone questionnaire about their child's/family's eating and cooking habits, up to two-weeks before and up to two weeks after the intervention. All parents will be asked to complete 4 online learning modules and up to 4 telephone sessions, over 8-weeks immediately. While participants in the waitlist control arm will receive the intervention 12 weeks later. Information from this study will help investigators examine the feasibility and efficacy of the Reboot Kids website to increase children's intake of vegetables and fruit and increase parent confidence in managing their child's eating habits, after finishing cancer treatment.

This study will help us learn about how diet, specifically processed-modified protein intake, influences factors related to the health of our gut bacteria and the risk of mood disorders such as depression and anxiety. When we consume high amounts process-modified proteins, these processed proteins may not be digested and used via the normal pathways, but fermented by the gut bacteria, producing various other biologically active compounds. The altered digestion and metabolism of these proteins may be linked with mood disorders, such as depression and anxiety, as a result of altered serotonin production. The researchers will assess how protein is being used in the body through assessing metabolites in blood and urine samples, and assess risk of depression and anxiety using questionnaires, to find out how these are influenced by dietary intake of processed-modified proteins.

The purpose of the proposed research is to develop an ongoing empirical evaluation of the effectiveness of transdiagnostic cognitive-behavioural treatments (tCBT) for negative emotional disorders provided at the Cairnmillar Anxiety & Depression Clinic (ADC). The primary aim of the research project is to to evaluate the efficacy of transdiagnostic Cognitive Behavioural Therapy (tCBT) for adults with anxiety or depressive disorders. Participants will receive 10 sessions of transdiagnostic cognitive behavioural therapy, completing measures of anxiety, depression, and other rated factors before, during, and following treatment. It is hypothesised that individuals with principal anxiety and depressive diagnoses will show equivalent treatment outcomes.

This research is investigating how to support children with disabilities to transition from receiving individual, health-focussed interventions and into participating in community sport. Sports Stars is a practitioner-led, peer-group sports intervention designed to facilitate transition to community sport for children with disabilities. It has been shown to be effective in improving sports skills and sports participation in ambulant children with cerebral palsy in Queensland, Australia. Sports Stars has received a high degree of support from parents and treating practitioners. There is significant potential for Sports Stars to be made widely available to children with a variety of disabilities across Australia and internationally through their local health practitioners. This study will investigate how well Sports Stars works for groups of children with a variety of disabilities in low socio-economic, culturally and linguistically diverse, and rural/remote communities.

Aim(s): This project aims to examine the feasibility of establishing a state-wide screening program in WA to detect congenital CMV-related hearing loss in high-risk infants. The project does not aim to determine if early treatments are effective, this is outside of the scope of the study. Primary Objectives: 1. To determine the incidence of congenital CMV infection in those infants who fail their newborn hearing screen in WA 2. To monitor the clinical progression of these patients/participants over time and their patterns of hearing loss to be able to better understand the disease in WA Secondary objectives: 1. a) To identify and address potential barriers to early detection of cCMV (less than 21 days) in order to facilitate feasible (cost-effective, minimally invasive) diagnosis via a saliva swab b) To determine whether early diagnosis has the potential to make time-critical treatment possible (within 30 days). 2. If targeted testing is found to be feasible - to create and implement a protocol which forms a clinical pathway for targeted testing of infants at high-risk of cCMV in WA. Hypothesis: We hypothesise that timely targeted cCMV screening is both important and feasible to implement into WA Newborn Hearing Screening Guidelines.

Physical activity is well known to improve health (physical, mental and social) when performed regularly. However, Australian men aged 35 to 54 years are not achieving sufficient levels and currently fall short on a number of health outcomes. Because of this, we are investigating the impact of a two different group-based 12-week exercise programs on the health and physical activity levels of men aged 35 to 54 years. One of the programs is focused around team-sport while the other group-circuit exercise. We hypothesize that greater social connections and exercising enjoyment will be generated through the team-sport program which will contribute to greater physical activity levels and health-related quality of life.