ANZCTR search results

Late talkers are children who show a later onset and slower progression of expressive language than their peers. Although late talking is prevalent in populations of young children, many do not receive early support. Some parent-directed interventions have been specifically created to increase child language skills. In these language-specific interventions, like Dialogic Reading, parents are trained in targeted strategies and techniques to scaffold their children’s language development. Other parent-directed interventions, like Group Triple P, have been designed to improve family functioning, child behaviour, and child development more generally. There is great potential for Group Triple P, which takes a broad-based approach, to also scaffold language learning and improve these outcomes for late-talking toddlers, but at present, studies have tested the intervention’s effectiveness in the language domain. This trial will randomize parents of late-talking 2- to 3-year-old children to either Group Triple P or Dialogic Reading interventions lasting 8 weeks, or a waitlist control group. Primary language outcomes will be assessed at baseline, post-test, and 3-month follow up. Other outcomes include parent-reported child behaviour and parenting style. All interventions and testing will be completed online. The Group Triple P program is disseminated globally by Triple P International, based in Brisbane, Australia (Triple P-Positive Parenting Program). Should this trial demonstrate effectiveness of the program in increasing expressive language performance, this established program can be readily repurposed to meet the needs late-talking toddlers, and their families, in the community. We anticipate that when parents participate in either intervention (Group Triple P or Dialogic Reading) children will have better language outcomes than those who receive no intervention in the same time period (those in the waitlist control group). We also hypothesize that children whose parents receive Group Triple P will show greater improvements in behaviour than those in the Dialogic Reading and waitlist control group.

Insomnia is a prevalent and debilitating disorder in Australia. The recommended treatment for insomnia is Cognitive Behavioural Therapy for insomnia (CBTi). However, there are very few clinicians in Australia with training in CBTi. Consequently, most patients with insomnia never access CBTi. Digital CBTi programs are an effective and potentially scalable intervention to manage insomnia. There are very few evidence-based digital CBTi programs available in Australia, and currently no publicly-available digital CBTi programs that provide personalised weekly behavioural therapy recommendations. This randomised controlled trial aims to investigate the effectiveness of a digital brief cognitive behavioural therpay for insomnia program, versus waitlist education control, on reducing insomnia symptoms in people with insomnia. It is hyopthesised that the group who receive the brief CBTi program will report a greater reduction in insomnia symptoms, compared to the group that receive education (waitlist control).

This study aims to identify predictors of engagement in, and outcomes following, a two-week app-based mindfulness intervention in a sample of adults with high levels of generalised anxiety. On an online platform, participants will complete a cognitive task and questionnaires regarding aspects of their mental health, personality traits and patterns in thinking and behaviour. They will then be asked to use the Smiling Mind app to practice mindfulness meditation daily for the next two weeks. App usage data will be obtained directly from Smiling Mind to gain a measure of participant engagement in the intervention. Psychological predictors of engagement in the intervention (minutes and days of practice) and outcome (pre-post change in generalised anxiety symptoms) will then be examined. It is expected that psychological factors related to the maintenance of generalised anxiety will predict poorer engagement outcomes. Outcomes related to anxiety, depression, stress and worry will be examined from pre to post intervention.

The primary objective of this research is to evaluate the preliminary effectiveness of a pragmatic ACLR rehabilitation program on the ability of patients to meet established return to sport discharge criteria and complete rehabilitation. Patients will complete a 5-phase rehabilitation program that addresses not only the physical deficits associated with ACL injury and reconstruction but also the contextual and patient-related factors which may present barriers to patients achieving return to sport discharge criteria and completing rehabilitation to evidence based standards. All interventions will be delivered at private outpatient physiotherapy clinics across the Gold Coast as part of clinical care. Patients We hypothesise that a pragmatic ACLR rehabilitation program in community-level athletes will be a feasible, clinically, and practically applicable model of patient care, which leads to a higher percentage of patients reaching return to sport discharge criteria and completing rehabilitation.

Pain after tonsillectomy is widely recognised to be not fully controlled by current pain management methods, especially in children. The aim of the study is to find out whether the use of the medication celecoxib will be useful in reducing this pain. The hypothesis is that celecoxib will be safe and effective to manage pain in children after tonsillectomy.

This is a pilot randomised controlled trial for recently discharged patients who are malnourished or at risk of malnutrition to receive a combined nutrition and exercise intervention at home. The control group will receive usual care (paper-based patient education materials) whilst the intervention group will receive personalised nutrition and exercise education for a 12 week period delivered by a digital app into their home. The research assistant who conducts baseline and the 12 week assessment will remain blinded to the group allocation. Outcome measures are: recruitment rate, dropout rate, nutrition and exercise adherence, and app engagement. Ten intervention group participants will also be invited to contribute to an interview at the conclusion of the intervention to obtain qualitative information on the app and intervention acceptability. All interviews (approx. 30mins each interview) will be completed using Zoom teleconference. The interview will be audio-recorded, and transcribed by a professional transcription service.

This study will characterize the development of the small blood vessels in the outermost layer of the kidney after very preterm birth (as early as 24 of 40 weeks of pregnancy) to term and to one year of age, using a new ultrasound mode with the ability to demonstrate blood flow in very small blood vessels (SMI ultrasound). The study will also compare the findings of the blood vessel development with measurements traditionally used to measure the function of the kidneys.

Background Patients who arrive at the emergency department are triaged by a trained triage nurse, but then may wait hours before being seen by an emergency doctor who decides if they need to be admitted to hospital. Early identification of patients requiring admission from the emergency department may help improve hospital efficiency. Previous research has suggested that machine learning may be able to be applied to triage data to predict if a patient will be admitted to hospital, however no research has been conducted in Western Australia. Objective Use machine learning to predict disposition for patients presenting to the emergency department based on data available at the time of triage. Project plan We will develop our dataset using retrospective triage data from Western Australian Emergency Departments. We will then use a portion of this dataset to train a machine learning model to predict emergency department disposition (such as admitted to ward, intensive care, or discharged). We will test the performance of our machine learning model on the remainder of the dataset and compare the prediction of the best performing machine learning model to the predictions of emergency doctors.

The purpose of this study is to see if a tracheostomy tube that has a window (called a fenestration) can increase airflow through the upper airway and improve speech when compared to tubes that don't have the window, in patients having surgery. Who is it for? You may be eligible to join this study if you are aged 18 years or above, and have been diagnosed with a head and neck cancer, and as part of your surgical management have an uncuffed fenestrated tracheostomy in-situ. Study details Patients will be first randomised to either the intervention (fenestrated inner tube) or the control (non-fenestrated inner tube), however all participants will experience both the intervention and the control at some point in time. The interventions will involve changing the inner tubes and seeing an effect on upper airflow. The study will involve several tests, including directly looking at where the fenestration (or, window) sits in the trachea. It is hoped this research will demonstrate that fenestrated tubes can improve airflow and therefore make it easier for patients to speak.

Peripheral artery disease (PAD) is an atherosclerotic disease characterised by blocked arteries and impaired blood supply to the legs, which causes muscle pain and limits waking capacity and the ability to undertake daily activities. This randomised placebo-controlled trial will test the effect of a novel treatment where patients with peripheral artery disease (PAD) will undertake daily periods of neuromuscular electrical stimulation (NMES) using the Revitive® Medic Coach footplate device. This is a class IIa medical device that is commercially available and approved by the Therapeutic Goods Administration (TGA) for use in Australia. Patients use the device by sitting comfortably and placing their bare feet on the rubber foot pads of the device, which deliver the stimulation to the muscles of the feet and legs. If successful, this simple treatment strategy will reduce symptoms (pain, claudication) and improve exercise tolerance (walking capacity) and quality of life, enabling patients to be more physically active.