ANZCTR search results

Thirty (30) research participants will undertake at-home Sonomat sleep studies, for 3 nights. Screening for sleep disordered breathing with preliminary STOP-Bang questionnaire, Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) to take place prior to overnight testing. A subset of ten (10) will be referred for concomitant diagnostic PSG and Sonomat studies prior to the first at-home Sonomat recording, whilst breathing room air. This will take place within an outpatient technician-supervised sleep laboratory. Disease severity indices including respiratory function tests and a 6-minute walk test, will be obtained at baseline, 6 and 12 months. The three (3) questionnaires (STOP-Bang, ESS and PSQI), lung function tests and 6 minute walk test will be repeated at 6- and 12-months following sleep studies.

This clinical trial is to evaluate the PK, safety, tolerability and food effects of PRAX-562 in healthy participants aged 18 to 55 years inclusive.

The current pilot study study aims to examine the effectiveness of an 8-session, 2-hour group, CBT and mindfulness intervention in reducing psychological distress and improving quality of life for women living with persistent pelvic pain. Women aged 18 years or over, who experience symptoms of persistent pelvic pain, will choose to participate in small group therapy intervention or Care as Usual levels (Open Label design).

This study is investigating whether routine collection of patient-reported outcome measures electronically at regular timepoints will have an impact on cancer patients symptoms and the number of hospital admissions. Who is it for? You may be eligible for this study if you are 18 or older, you have been diagnosed with an invasive solid cancer and you are about to start or have recently started treatment at one of the study hospitals in Queensland. Study details Participants enrolled in this study will be allocated to one of two study groups by chance. Participants allocated to the first group will be asked to complete a short questionnaire about their symptoms and any treatment side effects experienced on a schedule of either weekly, fortnightly or monthly depending on site the participant attends. It is anticipated that filling in the questionnaire will take about 10 minutes. Participants allocated to the second group won't be asked to complete any questionnaires prior to their treatment or follow-up visits, however, they will be asked you to complete questionnaires at regular time points over a 2 year period from consenting to the study. A pre-planned sub-study will assess the effects of the electronic symptom and treatment questionnaires on participants’ partners and/or carers (PROMISE-Carers Substudy. It is hoped this research will determine whether additional collection of patient symptoms and any treatment side effects will result more effective cancer patient care and have a positive impact on unplanned hospital presentations/admissions.

Sixty-six percent of the Australian adult population are overweight or obese. Recently, there has been growing interest in very-low-calorie diets (VLCDs) for weight loss, due to greater long-term weight loss success and being more tolerable than conventional weight loss programs. This nationwide cross-sectional survey aims to understand how Australian adults choose and follow very low calorie diet (VLCD) programs, their food and eating behaviours, and associated effects on self-perceived physical and mental health.

The purpose of this study is to learn whether injecting Pexa-Vec directly into the prostate cancer or into the blood stream is a safe and useful treatment for patients with prostate cancer, before they undergo standard surgery to remove the prostate gland. Who is it for? You may be eligible for this study if you are aged 18 years or older, have been recently diagnosed with prostate cancer and you haven't received any previous cancer treatments, including surgery, androgen deprivation therapy, chemotherapy or radiotherapy. Study details Participants in this study will have a small sample of prostate tissue (biopsy) taken before they receive any treatment. The first 10 participants will have a single dose of Pexa-Vec modified viral treatment injected directly into their prostate gland while they are in an MRI scanner, at least 4 weeks prior to prostate removal surgery. The second 10 participants will have two doses of Pexa-Vec treatment injected directly into their prostrate gland while they are in an MRI scanner, the first dose will be 6 weeks prior to surgery and the second dose at least 4 weeks prior to surgery. The last 10 participants will have two doses of Pexa-Vec treatment injected into their blood stream, the first dose will be at least 5 weeks prior to surgery and the second dose at least 4 weeks prior to surgery. All participants will undergo prostate removal surgery as scheduled by their doctor and will be asked to attend a series of follow-up appointments for up to 90 days after surgery to discuss their health and any complications they might have had. It is hoped this research may be used to improve health outcomes for future patients with prostate cancer by determining whether Pexa-Vec is safe and effective at changing the appearance of tumour and immune cells, while possibly reducing tumour cell growth prior to prostate removal surgery.

Effect of Yeast Beta Glucan (Saccharomyces cerevisiae) compared to a placebo on cold and flu symptoms in an Adult Population – A double blind, randomised controlled trial. The aim of this study is to assess the effectiveness of baker’s yeast beta glucan (Angel Yeast) for reducing incidence and severity of cold and flu symptoms compared to a placebo in otherwise healthy adults aged 18-65 years old.

This is a cluster randomised controlled trial that will test the effect of an audit and feedback strategy alone, as well as the effect of a combined strategy of audit and feedback plus an online menu labelling intervention compared to audit and feedback alone. The trial recruited 10 NSW government primary schools that already use an online canteen ordering system through which student lunch orders can be placed. The primary trial outcomes are the proportion of “Everyday”, “Occasional” and “Caution” foods (as classified by the NSW Healthy School Canteen Strategy) sold. Intervention effectiveness is assessed through analysis of the lunch order purchasing data that is automatically collected by the online ordering system.

Aphasia, an acquired language disorder affecting everyday communication, most commonly occurs after stroke with an incidence of approximately 30% of stroke survivors. Aphasia is associated with poor mental health with a high prevalence of anxiety and depression in both stroke survivors and their families. Speech pathology services include the provision of informational and personal adjustment counselling with regard to communication disorders. Speech pathologists frequently report providing counselling to support the psychological wellbeing in this client group but the majority report low knowledge, skills, confidence, and satisfaction in this practice (Rose et al, 2014). A systematic review of counselling training for speech pathologists working with people affected by post­stroke aphasia found that prequalification counseling training is variable and limited with some speech pathology training courses not offering any. Where offered, counselling training for working in post­stroke aphasia is limited to less than three hours of counselling observation, coursework, and practicum. After qualification, speech pathologists seek a wide range of counselling training and approaches from external sources ranging from short courses to doctorates in counselling and psychology in an array of approaches including in motivational interviewing, solution-focused brief training, narrative therapy, and basic counselling skills (Sekhon, Oates, Kneebone & Rose, 2019). Some stroke services provide low­level training (by clinical psychologists) to support the psychological needs of stroke survivors. This can include, for example, person centered, solution-focused, and problem-solving approaches. However, a majority of these studies are of low quality with a variety of outcomes and unvalidated measures (checklists) used in evaluating counseling training. Counselling training (of one day or more) is significantly and positively associated with speech pathologists' self­reported confidence and competence in counselling for managing psychological concerns in stroke survivors with aphasia and their carers (Sekhon, Oates, Kneebone & Rose, 2019). Research questions: 1) What is the effect of an online counselling training module for supporting psychological wellbeing (IV) on a) speech pathologists’ self-efficacy (DV) for counselling in post-stroke aphasia? b) speech pathologists’ self-reported confidence (DV) for 8 counselling skills (including self-reported competence for counselling) relevant in post-stroke aphasia? 2) Are effects of the training maintained at 4-weeks post-training? If this training module is effective, speech pathologists who feel they have low knowledge, skills, or confidence in supporting psychological wellbeing in post-stroke aphasia rehabilitation may gain confidence and self-efficacy from undertaking this training.

We are studying ways to improve cardio-metabolic health of individuals with chronic disease so that patients can better manage or avoid developing common conditions like obesity, diabetes and heart problems. The aim of this study is to determine whether using health technologies in specialist chronic disease clinics (telephone and web-based appointments and educational videos) is useful to support patients in developing healthy eating habits and regular exercise, in a way that can improve cardio-metabolic health. The information gathered from this study will be used to improve hospital clinic dietitian services, and give you the chance to assist in developing better access to health information and services that can be made available through technology