ANZCTR search results

This study attempts to harness advances in machine learning and artificial intelligence to faciliate monitoring of symptom fluctuations in Parkinson's disease. Participants will be asked to draw a spiral while wearing a smart watch with accelerometer function in both 'on' and 'off' state, based on clinical assessment. These samples will be used to train the algorithm, and an independent set of samples used for validation of the algorithm.

Utilising group singing intervention via Telehealth, conducted by as Speech Pathologist and a Music Therapist, we aim to improve vocal intensity (as defined by dB SPL) in patients with Parkinson's Disease

Low Phospholipid Associated Cholelithiasis (LPAC) is a cause of post-operative pain and recurrent gallstones after gallbladder removal (cholecystectomy). This is a randomised control trial of a medication called ursodeoxycholic acid in patients with LPAC to prevent pain post gallbladder surgery, improve quality of life, reduce hospital presentations and patient use of strong narcotic painkillers. This trial is a crossover trial where participants will be randomised to undergo a 1 year experimental (ursodeoxycholic acid) or control arm (placebo). The experimental or control arm will be prescribed a daily dose of 10mg/kg of ursodeoxycholic acid or placebo. Participants will then undergo a 2 week washout period before crossing over to the opposite arm to complete the study. The dose will be prescribed at 10mg/kg daily and can be titrated to a maximum of 20mg/kg daily at the discretion of the treating clinician. The primary study outcome is number of episodes of biliary pain. Secondary outcomes include quality of life, hospitalisations, liver ultrasound findings.

Vitamin B12 is a water-soluble vitamin found in fish, eggs, meat and milk. An adequate level of B12 blood concentration is necessary to prevent anaemia, cognitive impairment and neuropathy. B12 deficiency in older people is common. Symptoms include changes in mood and dizziness. It is important therefore that B12 deficiency is promptly treated, particularly in residents of aged care facilities who fall at a greater rate than the general population. Detection is complicated in cases of functional deficiency where B12 is within normal levels. Negative conditions of B12 deficiency can potentially be reversed by administering vitamin B supplements. Due to potential issues with the ageing gastrointestinal tract of the older adult, there is a requirement for an intervention using B12 supplements that bypass the gut. This study will investigate the effect of B12 supplementation in the form of skin patches on falls risk and mood in residents living in aged care facilities. As nurses are the primary clinicians involved in the reduction of falls in residents, demonstrating that falls risk in older people is impacted by the application of a non-prescription vitamin B12 patch could have major implications for nursing practice and public health policy.

This study aims to investigate the feasibility of implementing a whole-of-lifestyle intervention, the Younger Women’s Wellness after Cancer Program (YWWACP), to promote health-related quality of life. Who is it for? You may be eligible for this study if you are a woman aged 18-50 years inclusive, have completed any intensive treatment (surgery, chemotherapy, radiotherapy) for breast cancer in the previous 24 months and have no metastatic disease. Study details Participants will be randomly allocated to either a control arm who will receive standard care, or an intervention arm who will receive materials for a 12-week program designed to help them self-manage their chronic disease risk. They will also have three 30-60 minute individual, video consultations at weeks 1, 6 and 12 with a registered nurse. Participants will be asked to complete a variety of questionnaires throughout the program. Data from this study will go towards assisting the design of future programs to decrease the likelihood of treatment-related chronic disease for women with breast cancer.

This study aims to detect if there is a difference between activating your deep core muscles or your outer abdominal muscles in reducing the seperation of the abdominal muscles in women with diastasis of the rectus abdominis muscles following vaginal childbirth.

Overall study hypothesis: That increasing levels of resilience for low socio-economic status (SES) smokers who are contemplating quitting will help them quit smoking cigarettes. This study is likely to have an impact on improving the poorer health of lower SES populations by reducing smoking and increasing resilience, mental wellbeing, confidence, self-esteem and self-efficacy. This will address the high smoking prevalence rates in lower SES areas and the limited number of studies that have addressed this health problem in this target population. The cost-effectiveness analysis of the interventions will also provide important information to policy-makers. This study will utilise a Randomised Controlled Trial (RCT) design with one control group and three intervention groups. Once consented, participants will be randomised to one of these four groups: 1.) Arm 1-Mindfulness-integrated CBT (MiCBT) plus peer-support; 2.) Arm 2-Mindfulness Training (MT) plus peer-support, 3.) Arm 3-Setting Realistic Goals (SRG) plus peer-support 4.) Control. This will enable the study to determine which of the interventions works best when compared to the control group and also when compared to each other.

Obstructive sleep apnoea (OSA) is associated with increased risk of cardiovascular disease including hypertension, and screening for this condition and treatment may help reduce those risks. Furthermore, undiagnosed OSA is also linked to increased risk of postoperative complications in patients undergoing major surgery. Opportunities to screen using simplified diagnostic devices may be an important approach to addressing this clinical burden. Conventionally, the diagnosis of OSA is conducted by laboratory polysomnography (PSG) . A number of simplified devices are emerging commercially including single use disposable single or dual channel home monitoring. Single use disposable devices may emerge as the most convenient method for screening for OSA, especially in the home setting, however formal validation against PSG has not been previosly performed. The NightOwl is a small dual channel device that acquires data from a single fingertip and is now TGA registered as a single-use device in addition to a previously validated reusable option. The purpose of this study is to validate the single-use NightOwl compared to its reusable counterpart and the gold standard laboratory PSG for the diagnosis of OSA. Findings of this study will inform models of care that may include screening for OSA. This may be important in the clinical assessment of operative risk in those suspected of OSA undergoing major surgery.

There are an increasing number of families attending the Diabetes Clinic at Perth Children’s Hospital (PCH) who are using low carbohydrate (CHO) diets in an attempt to control blood glucose levels. However, little is known about what these children are eating and their overall nutritional status. The use of these diets is often promoted for weight loss in adults; however, there is minimal evidence on the short and long-term impacts on the use in children. As such, they are not promoted in clinical guidelines or in the clinical setting and families are seeking advice elsewhere such as non-evidence based online forums. This study aims to determine if children with T1D on low CHO diets are at greater risk of poor nutritional status, cardiovascular disease, osteoporosis and poor psychosocial functioning, compared to those who meet the daily recommended CHO targets for children. The findings will directly inform future studies and clinical practice to benefit children with T1D. All children aged 10 years and younger with T1D for more than 1 year will be invited to participate in the study. A population–based sample of 100 children will attend PCH on one occasion to measure: non-fasting bloods (to assess biomarkers for malnutrition, cardiovascular disease, kidney and liver function); height; weight; blood pressure; bone density and body composition (using dual energy X-ray absorptiometry (DXA)) and; questionnaires to assess physical activity and psychosocial functioning. Participating families will complete a 4-day food diary to assess dietary intake, which will be entered into a nutrient analysis program. Statistical analyses will determine associations between proportion of energy from CHO, types of CHO-containing foods, nutritional status and risk factors for co-morbidities.

Breast cancer is a common cancer diagnosed among females in Australia. Studies have demonstrated there may be an increased risk of radiation exposure in certain occupations. The primary aim of this research is to determine if breast cancer prevalence differs among female orthopaedic surgeons from that of the general population in Australia. Who is it for? You may be eligible for this study if you are a female who is a Fellow of the Australian Orthopaedic Association. Study details All participants in this study will be invited to complete one 30-minute survey where they will complete questions regarding their occupational history and medical history. It is hoped that this study will help determine what the prevalence of breast cancer is within Australian female orthopaedic surgeons.