ANZCTR search results

This project will involve conducting a national, web-based survey of Australian adults with asthma about their health and their treatment, to describe the frequency and burden of symptoms, risk factors, treatments being taken, and use of healthcare services”.

In this randomised, double-blind, placebo-controlled study, 100 adults who are currently experiencing osteoarthritis of the knee will be randomly assigned to receive capsules containing either a curcumin extract (1000mg a day) or placebo for 8 weeks. We will assess changes in knee pain and quality of life via validated self-report measures (to be completed at various time points throughout the study). We will also evaluate pre and post changes in functional/physical performance via several performance-based tests.

This project aims to implement and evaluate the HOW-R-U? telephone peer support program to address social isolation, loneliness and depressive feelings in a COVID-19 affected cohort served by Northern Health. This project will provide supportive telephone calls in the time after being diagnosed with COVID-19, or working and living with those with COVID-19, which we hypothesise will help improve these feelings of isolation, loneliness and depression.

In this randomised, double-blind, placebo-controlled study, 120 adults who are currently experiencing unsatisfactory sleep will be randomly assigned to receive tablets containing either a high-dose saffron extract (28mg a day), low-dose saffron extract (14mg a day), or placebo for 28 days.. We will assess change in sleep quality, quality of life, and mood via several validated self-report measures (to be completed at various time points throughout the study). We will also examine changes in evening salivary concentrations of cortisol and melatonin.

The purpose of this trial is to investigate the dose-related effects of intraduodenal administration of the bitter agonist, quinine, a non-nutritive (calorie-free) compound, on gastric emptying, gut and gluco-regulatory hormone, postprandial blood glucose and gastrointestinal symptoms in people with type 2 diabetes. The relationship between outcomes and the ability to detect bitter in the oral cavity will also be investigated. We have found previously that specific dietary nutrients, when given into the small intestine in small amounts (and so not contributing significantly to overall energy intake) have the unique ability to substantially stimulate gastrointestinal functions leading to marked improvements in postprandial blood glucose. There has been an increasing interest in the effects of bitter compounds, some of which also occur in the diet, including thio-urea compounds in certain vegetables or fruit, or quinine in tonic water, with reported effects on gut functions.

General Objective To introduce uniform use of vaginal antiseptic wash immediately prior to Caesarean section and to determine the best antiseptic wash material in reducing post-operative infections or complications. Specific Aims 1. To determine the number of post-CS infections among women that will undergo pre-operative vaginal cleansing with either 1% povidone iodine or chlorohexidine or no toileting (control) during elective CS 2. To determine the number of post-CS infections among women that will undergo pre-operative vaginal cleansing with 1% povidone iodine or chlorohexidine or no toileting (control) during emergency CS 3. To compare the rate of infections among the three groups that receiving either 1% povidone iodine or chlorohexidine or no toileting for vaginal irrigation prior to any kind of CS 4. To identify the best antiseptic wash and methods for vaginal irrigation prior to CS for developing a uniform guideline through locally generated evidence 5. To determine the factors that may influence the outcomes such as post-CS infections or related complications

Artificial sweeteners, also known as non-nutritive sweeteners (NNS) are used worldwide. A significant proportion of the Australian adult population consume NNS especially those on weight loss diets and by diabetics to control their glycaemia. However, no study till date has evaluated the impact of NNS consumption in diabetic population. The purpose of this study is to investigate the impact of 12 week NNS consumption on blood sugar levels in people with Type 2 diabetes.

The Chronic Conditions Course is a remotely-delivered psychological treatment that has been designed on the principles of cognitive behavioural therapy. It is designed for adults with a chronic health condition and associated impact on their emotional wellbeing. It involves five lessons and other additional materials delivered online over an 8 week period. Participants also receive telephone support from trained psychologists. The efficacy of the Chronic Conditions Course has been examined in a randomised controlled trial, with promising results (long-term follow-up data collection is ongoing). The aim of our study is to evaluate the efficacy of the course in a larger group of participants. We hypothesise that, compared to a delayed treatment waitlist group, participants in the Chronic Conditions Course will report greater symptom improvements (in terms of mood, anxiety and level of disability). By recruiting a large group of participants, we are also aiming to understand what particular groups of people (or what participant characteristics) may benefit most from the Chronic Conditions Course.

The study will investigate whether a diet high in foods rich in Resistant Starch (RS), with or without the addition of a RS supplement, changes the gut microbial composition and blood glucose control compared with usual dietary advice (control) in women with newly diagnosed Gestational Diabetes (GDM). Data will be collected at Baseline, Day 7 of intervention, and 36-weeks of gestation and include dietary RS consumption, stool microbial analysis and short chain fatty acid content, fasting and post-meal blood glucose levels, time in optimal glycaemic range, the requirement for glucose-lowering medication, maternal and neonatal health outcomes, and health care costs. We hypothesise that, compared with standard GDM dietary advice, women with a high dietary intake of RS beginning at the diagnosis of GDM will show a reduction in fasting blood glucose levels and other measures of blood glucose control.

This is a prospective double-blind cross-sectional cohort study, assessing the difference in knee stability in the sagittal (forwards and backwards) between two commonly used implants, and the effect that this has on patient satisfaction. Patients with a primary diagnosis of knee osteoarthritis who are over 18 years of age and are booked for a TKA at Fremantle Hospital receiving either an AttuneTM or TriathlonTM primary knee replacement will be recruited. Patients will be recruited at their booking visit, and consenting participants will be asked to complete validated Patient Reported Outcome Measure (PROM) questionnaires. Sagittal stability will be objectively measured by a device called a GNRB arthrometer at 30 degrees and 90 degrees of knee flexion. 134N of force will be applied to the top of the shin bone whilst the thigh bone is held steady and anterior displacement of the tibia will be measured. Clinical evaluation of stability will occur through physical examination. Sagittal stability is defined according to the amount anterior translation of the tibia with <5mm deemed stable, 6-10mm partially unstable and >10mm unstable. Range of movement in flexion and extension will be assessed with a goniometer and recorded. Radiological assessment prior to their surgery will be routine as per all joint replacements; pre-operative alignment and post-operative alignment will be assessed with long-leg alignment views. Each surgeon involved will use only 1 prosthesis type for all participating patients under their care (TriathlonTM or AttuneTM) in line with current practice. Participants and the examiner performing assessment of sagittal stability will be blinded to implant type. All implant details (size, side, patella, polyethylene type, polyethylene thickness and patella resurfacing) will be explicitly recorded and tracked. Patients are randomly assigned to each surgeon according to the participating hospital's outpatient referral system, as is current practice. Pre-operative demographic analysis of patient characteristics will be used to screen for selection bias. TKA will be performed as per the surgeon’s preferred technique according to the manufacturer’s recommendations. Plain radiographs, PROMs and assessment of sagittal stability will be repeated at 6 weeks and 12 months follow up.