ANZCTR search results

This is a pilot study of pain psychology therapy delivered by virtual reality to chest trauma patients admitted to hospital with acute pain. In this research study, VR software to deliver a suite of pain psychological therapies has been created. The suite contains three distinct modules; a pain education module, teaching the method of progressive muscle relaxation, and pain visualisation therapy. Patients will be provided the VR therapy as an adjunct to their existing acute pain management protocol of opioid medications and catheter-based local anaesthesia nerve block infusions. The primary objective of this prospective pilot study of 40 patients is to confirm feasibility, acceptability, and obtain initial effectiveness results on pain scores, opioid consumption, and pulmonary function.

This is a single-arm, uncontrolled feasibility and pilot study of a lifestyle weight management program for Duchenne muscular dystrophy (DMD). The aims of this study are to: * assess feasibility and acceptability of SNOW-P * determine the impact of SNOW-P on: weight, BMI, physical function, physical activity level, blood pressure, quality of life, fatigue, dietary intake and adverse events This study will recruit young people with DMD who have obesity. The expected outcomes for this study will be improved understanding of how to manage obesity in DMD and improved nutrition and wellbeing for young people after participating in a weight management program.

It is suggested that incomplete digestion of proline-rich proteins, including gluten, may be a cause of food intolerance and food allergies in some people, and lead to gut discomfort and distress. Foods containing these proline-rich proteins are widespread in our diet and are present in a broad range of foods. To improve the digestibility of the protein in these foods, Biohawk has developed a unique enzyme blend that can be added during food manufacturing. Anecdotal evidence suggests that bread made with gluten-rich flour treated with this enzyme blend is well tolerated by people who report having sensitivity to wheat-based products. However, independent testing is needed to confirm this, and to determine whether total protein and proline digestibility is improved. The main aim of this project is to evaluate the protein digestibility of bread products made from gluten-rich flour treated with an enzyme blend in healthy ileostomy participants.

The purpose of the proposed project is to examine the acceptability and efficacy of a low-intensity CBT-based self-management program, the Wellbeing Neuro Course to support the emotional wellbeing of adults with neurological disorders. The Course contains a 6-lesson 10-week internet delivered program. Participants will have brief weekly contact with a psychologist as they work through the Course. A two-group CONSORT-R Compliant randomised controlled trial (RCT) design will be employed, where participants are randomised to one of two groups: 1. Treatment Group (n = 100) 2. Waitlist Control Group (n = 100) Participants in the Active Treatment Group will receive full access to the Wellbeing Neuro Course. Participants are asked to complete standardised questionnaires at 4 main time points: Pre-treatment, mid-treatment, post-treatment, and 3-month follow-up. The Waitlist Control Group will receive the same treatment after the Active Treatment Group has completed the 10-week Course

This study aims to investigate whether a short period of coaching sessions, delivered in person with a clinician or via videocall, helps families of young children who have recently become aware that there may be a risk of autism spectrum disorder. We hypothesise that families need support and guidance in this period, and that these needs are not currently being met by health or disability services. is the researchers' hope that findings from this study will help families in limbo, waiting for diagnostic assessments and unsure what to do or how to help their child in the meantime. This may assist to minimise wasteful waiting periods in a child's early years, when intervention can be of great benefit to children, families and communities.

In this study we propose to investigate the effects of applying TMS using a novel individualised site targeting methodology with a behavioural outcome for the purpose of enhancing cognitive flexibility.

There is a need to identify WHY fall and fracture risk is increased among Aboriginal and Torres Strait Islander (Indigenous) Australians. Indigenous Australians have a substantially greater fracture risk: Indigenous men are 50% and women are 26%, more likely to experience a hip fracture vs non-Indigenous Australians. Hip fractures occur at a much younger age in Indigenous vs non-Indigenous Australians (men:65 vs 81yrs; women:74 vs 83yrs). Fall-related injuries in Indigenous Australians increased by an average of 10%/year, while the average increase in non-Indigenous Australians was 4.3%/year. Findings from this study will identify why falls and minimal trauma fractures are higher among Indigenous adults. Data collected will enable us to determine the age of osteoporosis (bone fragility) and sarcopenia (decreased muscle function) onset, whether these are different to non-Indigenous Australians, and the best “window” for osteoporosis and sarcopenia screening and prevention strategies. Currently, there is no reference database for DXA-derived areal bone mineral density (aBMD) in Indigenous Australians, which may result in underestimation of fracture risk in this population. Data collected will be compiled into a reference database for Indigenous Australians as a starting point to collect data from Indigenous Australians in other geographic regions, with the aim of improving fracture risk prediction. Together, these data will enable health care professionals to improve screening, diagnosis and treatment of osteoporosis.

This study will compare the effects on myopia progression over the course of one year for eyes wearing MiSight 1 Day contact lenses compared to ACUVUE OASYS for PRESBYOPIA contact lenses.

LOCATE-NAFLD is a randomised trial, comparing two alternative models of care for NAFLD (usual care versus LOCATE-NAFLD care). Participants randomised to the intervention will be screened in the community with a non-invasive device called a Fibroscan, a scan they may otherwise have waited months to receive. The scan results can then determine if their disease, with high risk patients sent to a specialist, and low-risk patients returned to the care of their GP, reducing unnecessary hospital appointments. Through this faster assessment and stratification of patients in the community, the study aims to greatly reduce referrals for hospital-based appointments, and improve surveillance of high-risk disease, resulting in enhanced management of complications that result in avoidable, high cost hospital admissions.

This proposed pre-post test intervention study will investigate the effectiveness of Loud and Proud maintenance group therapy for speech difficulties associated with Parkinson's Disease. The goal of this therapy approach is to increase the loudness of someone with Parkinson's Disease's speech. This project will explore gains made by 20 participants following attendance at a maintenance group. It will also refine our understanding of factors influencing the gains following this therapy. This study will include participants who completed LSVT X (a less intensive version of LSVT LOUD) or LSVT LOUD intervention less than 2 years previously. the study will include cognitive measures to explore the influence of cognitive skills on outcomes, and offer home practice. Multiple baseline measurements will be carried out in order to determine if any improvements in speech made post-treatment are due to therapy.