ANZCTR search results

Plantar heel pain, which is often called Plantar Fasciitis, is a common cause of pain and disability. The condition appears to include the proliferation of blood vessels and nerves in the foot which contribute to the experience of pain. The primary aim of the current study is to determine whether transcatheter arterial embolisation of abnormal neovasculature about the foot improves pain, and specifically if adding an anti-inflammatory medication prior to embolisation affects pain differently than embolisation alone. Secondary aims include whether the treatments affect physical function and quality of life. The study is a randomised trial. People are eligible if they have plantar foot pain that has not responded to other forms of traditional management such as medications, podiatry or physiotherapy. Participants will be randomly allocated to one of two groups. Participants in one group will receive embolisation of abnormal vessels about the foot. Participants in the second group group will receive embolisation and an anti-inflammatory medication that is injected in the blood vessels in the foot. All participants will be assessed shortly before the intervention and then 1, 6 and 12 months after the intervention. Assessment includes a variety of questionnaires and physical tests.

This study aims to assess the cardiovascular risk in people with gout, through performing scanning the heart, and then performing the scan in 6 months. We will determine the impact of having an acute flare of gout on the scans, which is a surrogate of cardiovascular risk. This will help us understand the effect of acute inflammation on cardiovascular risk in gout,

This research project is being conducted to look at the safety, tolerability and pharmacokinetics (PK, how the human body processes a substance) of iCo-019 (oral Amphotericin B when given to healthy volunteers as multiple oral doses for to 10 consecutive days.

In this study we aim to collect dental, saliva, blood and stool samples to characterise the gut microbiome profile of individuals with cardiovascular disease, specifically heart failure patients which include those requiring placement of a ventricular assist device or a heart transplant and compare their microbiome profile to that of healthy individuals. Individuals with cardiovascular disease will have an alteration in the composition and functionality of their gut microbiome compared to healthy individuals.

We are doing a research project to evaluate the Virtual Clinical Pharmacy Service (VCPS) that is being delivered to 8 hospitals in Western and Far West NSW Local Health Districts via a video link. The aim of the virtual pharmacy is to improve medication management, reduce medication harm, help patients manage their medications, and support staff with patients. Routine data collection from patients' electronic medical record will identify if medication management improves, medication harms such as falls are reduced and if people are less likely to be readmitted to hospital compared to those who do not see a pharmacist.

This research project is being conducted to look at the safety, tolerability, pharmacokinetics (PK, how the human body processes a substance) and pharmacodynamics (PD, how the human body interacts with a substance) of SIR1-365 when given to healthy volunteers as a single oral dose or as multiple oral doses for up to 10 consecutive days.

Regular HIV/sexually transmitted infection (STI) screening is particularly important for those at highest risk e.g. for men who have sex with men (MSM). Several national guidelines recommend sexually active individual to have an STI screening every 3 months. The aim of the proposed study will be to evaluate whether reframing SMS reminder messages may impact the retesting rates of clients of Melbourne Sexual Health Centre.

This study aims to clarify the role of neurotransmitters dopamine and noradrenaline in distractor processing. While previously shown to improve attention, it is unclear what neural processes underpin this effect. We intend to use EEG analysis, a task that implements distracting stimuli, and administration of a drug that increases transmission of dopamine and noradrenaline (methylphenidate) to help us understand the neural mechanisms of this effect.

Background: Virtual reality (VR) is technology that completely immerses users in a virtual world and was originally developed for entertainment. VR games have been used during medical procedures to provide drug-free pain relief, and to increase motivation to exercise in conditions such as stroke, enabling potential new applications in rehabilitation. The enjoyment and distraction VR provides is fairly well understood, however the complex mechanisms underpinning pain relief are not. Aims: My aims are to combine VR with exercise in a novel approach that targets different contributors to chronic knee pain; the peripheral contributions and the central contributions. This study will provide pilot data on the types of visual illusions that impact pain and movement perception. Design: This application is to pilot the use of VR for larger scale studies, and to evaluate the visual contribution to movement and pain perception in people with and without anterior knee pain. To do this we will manipulate the amount people perceive they are moving (change in gain) compared to the real world. Participants will be asked to wear a VR headset while performing a number of squats, and will have their pain, squat depth and other clinical examination assessed.

This trial is a phase IIa study of ultra-early minimally invasive haematoma removal acutely following ICH. The aim of the study is to demonstrate feasibility, safety and preliminary efficacy of this treatment in patients with acute intracerebral supratentorial haemorrhage of greater than 20mL volume and less than 12 hours duration.