ANZCTR search results

Older people living in residential care facilities (RACFs) are some of the most vulnerable in society with increasingly complex health and personal care needs. Transfers to Emergency Departments and hospitalization are common. The Aged Care Emergency Program was developed to better support acutely unwell residents in RACFs. It is a multi-component service level intervention designed to support RACF staff in identifying and addressing medical needs with an aim to reduce unnecessary hospital admissions. Using a stepped wedge non-randomised cluster design, a large scale evaluation was made of the roll out of the program across a broad geographic area of Hunter New England local health district.

This study compared brief intervals of stair climbing to moderate-intensity walking and physical activity guidelines for adults with metabolic syndrome.

This study examines the difference between implanting a conventional pacemaker and a novel technique in pacemaker implantation where the pacing lead is implanted in the His-bundle and deep septal region of the heart. This novel technique could circumvent the known adverse effects of conventional pacemakers, and result in improved patient outcomes. Conduction system pacemaker is hypothesised to result in improved cardiac function compared to conventional pacemakers.

Broken ribs are common and hurt. The pain from broken ribs can restrict breathing and may cause serious problems (for example lung infections) for some people. Two common techniques used for managing pain are the Paravertebral Block, and the Erector Spinae block. Both techniques can be effective, but it is not clear which technique is better or safer. This pragmatic study is looking to see if these techniques are the same or not, in terms of both benefits (e.g. relieving pain, improved lung function), and potential harms (e.g. collapsed lung, need for intensive care).

The aim of this study is to investigate whether a course of water based exercises, in addition to usual Physiotherapy, improves symptoms and quality of life in patients with Persistent Pelvic Pain due to endometriosis, when compared to usual Physiotherapy alone. If women in this study gain relief from their symptoms, hydrotherapy may become another treatment option for this condition. The results of this research will be used to decide whether hydrotherapy is useful to help treat this condition and whether it can be provided by the RBWH Physiotherapy Department.

This first in human study of LMR-123 will investigate the safety, tolerability and PK of single ascending doses of LMR-123 compared to placebo in healthy subjects.

The purpose of this research is to explore the early safety and feasibility of a device that might eventually be useful in delaying progression of Alzheimer’s Disease.

This is a single-centre, randomised, double blind, single and multiple ascending dose study to assess the safety and pharmacokinetics (PK) of OCX063 in healthy volunteers. Part A: Single Ascending Dose (SAD) cohorts will assess the safety and tolerability of single doses of OCX063. Part B: One SAD cohort will return for an additional dose to determine the effect of food on OCX063 PK. Part C: Multiple Ascending Dose (MAD) cohorts will assess the safety and tolerability of multiple doses of OCX063, when administered daily for 14 days.

Lung transplant recipients at Alfred Hospital are experiencing significant unintentional weight gain within the 12 months after their surgery; resulting in more overweight and obese patients within this cohort. There are no studies investigating the management of weight gain among this population. The aim of this study is to explore whether 4 group education sessions based on healthy eating and physical activity, followed by 4 phone calls and 2 face-to-face consultations with a dietitian over 12 months can assist in preventing unintentional weight gain better than current usual care. Hypothesis: Intensive group nutrition and exercise education combined with individual phone coaching over the 12 months following lung transplant will reduce unintentional weight gain in the healthy weight and overweight population, compared with usual care.

Pelvic girdle pain is a common problem experienced during pregnancy that affects pregnant women significantly. Treatment options are needed for pelvic girdle pain in pregnancy especially when provided under ‘real-life’ circumstances and in terms that matter to the patient. This study aims to investigate the feasibility of conducting a randomised controlled trial on the effectiveness of massage in treating pregnant women with pelvic girdle pain. The expected outcome from this study is information on recruitment, randomisation, and the outcome measures for use in a large-scale study. The industry partner will be able to teach massage using evidence-based research.